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VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint.
Brain Res. 2004 May 15; 1008(1):131-6.BR

Abstract

Immunohistochemistry for vanilloid receptor subtype 1 (VR1), vanilloid receptor 1-like receptor (VRL-1) and P2X3 receptor was performed in the rat temporomandibular joint (TMJ). Blood vessels in the articular disk and capsule, the synovial membrane and the fibrous tissue around the condylar process were innervated by VR1- or P2X3 receptor-immunoreactive (ir) nerve fibers. However, VRL-1-immunoreactivity (ir) could not be detected in the TMJ. Retrograde tracing and immunohistochemical methods revealed that 25%, 41% and 52% of TMJ neurons in the trigeminal ganglion (TG) exhibited VR1-, VRL-1- and P2X3 receptor-ir, respectively. VR1-ir TMJ neurons were mostly small to medium-sized, whereas VRL-1- and P2X3 receptor-ir TMJ neurons were predominantly medium-sized to large. In addition, 73%, 28% and 44% of VR1-, VRL-1- and P2X3 receptor-ir TMJ neurons, respectively, coexpressed calcitonin gene-related peptide (CGRP)-ir. The present study suggests that the TMJ has abundant nociceptors which respond to vanilloid compounds, protons, heat and extracellular ATP.

Authors+Show Affiliations

Department of Orthodontics, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. hiroichi@md.okayama-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15081392

Citation

Ichikawa, H, et al. "VR1-, VRL-1- and P2X3 Receptor-immunoreactive Innervation of the Rat Temporomandibular Joint." Brain Research, vol. 1008, no. 1, 2004, pp. 131-6.
Ichikawa H, Fukunaga T, Jin HW, et al. VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint. Brain Res. 2004;1008(1):131-6.
Ichikawa, H., Fukunaga, T., Jin, H. W., Fujita, M., Takano-Yamamoto, T., & Sugimoto, T. (2004). VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint. Brain Research, 1008(1), 131-6.
Ichikawa H, et al. VR1-, VRL-1- and P2X3 Receptor-immunoreactive Innervation of the Rat Temporomandibular Joint. Brain Res. 2004 May 15;1008(1):131-6. PubMed PMID: 15081392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint. AU - Ichikawa,H, AU - Fukunaga,T, AU - Jin,H W, AU - Fujita,M, AU - Takano-Yamamoto,T, AU - Sugimoto,T, PY - 2004/02/19/accepted PY - 2004/4/15/pubmed PY - 2004/6/29/medline PY - 2004/4/15/entrez SP - 131 EP - 6 JF - Brain research JO - Brain Res. VL - 1008 IS - 1 N2 - Immunohistochemistry for vanilloid receptor subtype 1 (VR1), vanilloid receptor 1-like receptor (VRL-1) and P2X3 receptor was performed in the rat temporomandibular joint (TMJ). Blood vessels in the articular disk and capsule, the synovial membrane and the fibrous tissue around the condylar process were innervated by VR1- or P2X3 receptor-immunoreactive (ir) nerve fibers. However, VRL-1-immunoreactivity (ir) could not be detected in the TMJ. Retrograde tracing and immunohistochemical methods revealed that 25%, 41% and 52% of TMJ neurons in the trigeminal ganglion (TG) exhibited VR1-, VRL-1- and P2X3 receptor-ir, respectively. VR1-ir TMJ neurons were mostly small to medium-sized, whereas VRL-1- and P2X3 receptor-ir TMJ neurons were predominantly medium-sized to large. In addition, 73%, 28% and 44% of VR1-, VRL-1- and P2X3 receptor-ir TMJ neurons, respectively, coexpressed calcitonin gene-related peptide (CGRP)-ir. The present study suggests that the TMJ has abundant nociceptors which respond to vanilloid compounds, protons, heat and extracellular ATP. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/15081392/VR1__VRL_1__and_P2X3_receptor_immunoreactive_innervation_of_the_rat_temporomandibular_joint_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006899304003191 DB - PRIME DP - Unbound Medicine ER -