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Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats.
Neuropharmacology 2004; 46(7):954-65N

Abstract

Cannabinoid-MDMA interactions were examined in male Wistar rats. MDMA (4 x 5 mg/kg or 2 x 10 mg/kg over 4 h on each of 2 days) was administered with or without Delta 9-tetrahydrocannabinol (THC) (4 x 2.5 mg/kg), the synthetic cannabinoid receptor agonist CP 55,940 (2 x 0.1 or 0.2 mg/kg) or the cannabinoid receptor antagonist SR 141716 (2 x 5 mg/kg). Co-administered Delta 9-THC and CP 55,940 but not SR 141716 prevented MDMA-induced hyperthermia, causing a powerful hypothermia. Co-administered Delta 9-THC, CP 55,940 and SR 141716 all tended to decrease MDMA-induced hyperactivity. Co-administered Delta 9-THC provided protection against the long-term increases in anxiety seen in the emergence test, but not the social interaction test, 6 weeks after MDMA treatment. Co-administered Delta 9-THC and CP 55,940, but not SR 141716, partly prevented the long-term 5-HT and 5-HIAA depletion caused by MDMA in various brain regions. SR 141716 administered with CP 55,940 and MDMA prevented the hypothermic response to the CP 55,940/MDMA combination but did not alter the CP 55,940 attenuation of MDMA-induced 5-HT depletion. These results suggest a partial protective effect of co-administered cannabinoid receptor agonists on MDMA-induced 5-HT depletion and long-term anxiety. This action appears to operate independently of cannabinoid CB1 receptors.

Authors+Show Affiliations

School of Psychology, University of Sydney, Sydney, NSW 2006, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15081792

Citation

Morley, Kirsten C., et al. "Cannabinoids Prevent the Acute Hyperthermia and Partially Protect Against the 5-HT Depleting Effects of MDMA ("Ecstasy") in Rats." Neuropharmacology, vol. 46, no. 7, 2004, pp. 954-65.
Morley KC, Li KM, Hunt GE, et al. Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats. Neuropharmacology. 2004;46(7):954-65.
Morley, K. C., Li, K. M., Hunt, G. E., Mallet, P. E., & McGregor, I. S. (2004). Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats. Neuropharmacology, 46(7), pp. 954-65.
Morley KC, et al. Cannabinoids Prevent the Acute Hyperthermia and Partially Protect Against the 5-HT Depleting Effects of MDMA ("Ecstasy") in Rats. Neuropharmacology. 2004;46(7):954-65. PubMed PMID: 15081792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats. AU - Morley,Kirsten C, AU - Li,Kong M, AU - Hunt,Glenn E, AU - Mallet,Paul E, AU - McGregor,Iain S, PY - 2003/08/21/received PY - 2003/12/15/revised PY - 2004/01/07/accepted PY - 2004/4/15/pubmed PY - 2004/6/30/medline PY - 2004/4/15/entrez SP - 954 EP - 65 JF - Neuropharmacology JO - Neuropharmacology VL - 46 IS - 7 N2 - Cannabinoid-MDMA interactions were examined in male Wistar rats. MDMA (4 x 5 mg/kg or 2 x 10 mg/kg over 4 h on each of 2 days) was administered with or without Delta 9-tetrahydrocannabinol (THC) (4 x 2.5 mg/kg), the synthetic cannabinoid receptor agonist CP 55,940 (2 x 0.1 or 0.2 mg/kg) or the cannabinoid receptor antagonist SR 141716 (2 x 5 mg/kg). Co-administered Delta 9-THC and CP 55,940 but not SR 141716 prevented MDMA-induced hyperthermia, causing a powerful hypothermia. Co-administered Delta 9-THC, CP 55,940 and SR 141716 all tended to decrease MDMA-induced hyperactivity. Co-administered Delta 9-THC provided protection against the long-term increases in anxiety seen in the emergence test, but not the social interaction test, 6 weeks after MDMA treatment. Co-administered Delta 9-THC and CP 55,940, but not SR 141716, partly prevented the long-term 5-HT and 5-HIAA depletion caused by MDMA in various brain regions. SR 141716 administered with CP 55,940 and MDMA prevented the hypothermic response to the CP 55,940/MDMA combination but did not alter the CP 55,940 attenuation of MDMA-induced 5-HT depletion. These results suggest a partial protective effect of co-administered cannabinoid receptor agonists on MDMA-induced 5-HT depletion and long-term anxiety. This action appears to operate independently of cannabinoid CB1 receptors. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/15081792/Cannabinoids_prevent_the_acute_hyperthermia_and_partially_protect_against_the_5_HT_depleting_effects_of_MDMA__"Ecstasy"__in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028390804000127 DB - PRIME DP - Unbound Medicine ER -