Tags

Type your tag names separated by a space and hit enter

Prognostic indicators for long term outcome following radical retropubic prostatectomy for prostate cancer involving the seminal vesicles.
Urol Oncol. 2004 Mar-Apr; 22(2):107-11.UO

Abstract

Seminal vesicle involvement at the time of radical prostatectomy (RP) for prostate cancer has been equated with metastatic disease. We review our biochemical freedom from disease results following RP in patients with seminal vesicle involvement with particular attention to identifying variables that may be predictive of disease recurrence. We retrospectively reviewed our surgical database and identified patients with pT3b (2002 AJCC) prostate cancer at RP [corrected]. There were 70 cases without lymph node involvement and with available clinical follow-up identified. Any patient receiving androgen deprivation therapy, radiation therapy, or with a sustained PSA elevation greater than 0.2 ng/mL was considered a biochemical failure. Results were calculated using the Kaplan-Meier method. Mean age was 63.4 (range 45.7-79.5) years, mean preoperative PSA was 11.3 ng/mL (range 2-60), mean biopsy Gleason score was 7.2 (range 4-9), mean RP Gleason score was 7.5 (range 5-9), and median follow-up time was 61.5 months (range 2.3-160.6). Overall, 33/70 (47%) patients were without evidence of disease without further therapy. For patients with pT3bN0Mx prostate cancer, margin status, capsular invasion, and PSA were not statistically significant risk factors for disease progression. Gleason score and major Gleason grade were the only statistically significant variables that predicted disease progression. A specimen Gleason score of greater than 7 and major Gleason grades greater than 3 were associated with an increased rate of disease progression in this patient group.

Authors+Show Affiliations

Johnson CW
Department of Urology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Anastasiadis AG
No affiliation info available
McKiernan JM
No affiliation info available
Salomon L
No affiliation info available
Eaton S
No affiliation info available
Goluboff ET
No affiliation info available
Olsson CA
No affiliation info available
Benson MC
No affiliation info available

MeSH

AgedDisease ProgressionFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPredictive Value of TestsPrognosisProstate-Specific AntigenProstatectomyProstatic NeoplasmsRetrospective StudiesRisk FactorsSeminal VesiclesSurvival RateTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15082006

Citation

Johnson, Christopher W., et al. "Prognostic Indicators for Long Term Outcome Following Radical Retropubic Prostatectomy for Prostate Cancer Involving the Seminal Vesicles." Urologic Oncology, vol. 22, no. 2, 2004, pp. 107-11.
Johnson CW, Anastasiadis AG, McKiernan JM, et al. Prognostic indicators for long term outcome following radical retropubic prostatectomy for prostate cancer involving the seminal vesicles. Urol Oncol. 2004;22(2):107-11.
Johnson, C. W., Anastasiadis, A. G., McKiernan, J. M., Salomon, L., Eaton, S., Goluboff, E. T., Olsson, C. A., & Benson, M. C. (2004). Prognostic indicators for long term outcome following radical retropubic prostatectomy for prostate cancer involving the seminal vesicles. Urologic Oncology, 22(2), 107-11.
Johnson CW, et al. Prognostic Indicators for Long Term Outcome Following Radical Retropubic Prostatectomy for Prostate Cancer Involving the Seminal Vesicles. Urol Oncol. 2004 Mar-Apr;22(2):107-11. PubMed PMID: 15082006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic indicators for long term outcome following radical retropubic prostatectomy for prostate cancer involving the seminal vesicles. AU - Johnson,Christopher W, AU - Anastasiadis,Aristotelis G, AU - McKiernan,James M, AU - Salomon,Laurent, AU - Eaton,Samuel, AU - Goluboff,Erik T, AU - Olsson,Carl A, AU - Benson,Mitchell C, PY - 2003/03/28/received PY - 2003/05/20/revised PY - 2003/08/11/accepted PY - 2004/4/15/pubmed PY - 2004/11/17/medline PY - 2004/4/15/entrez SP - 107 EP - 11 JF - Urologic oncology JO - Urol Oncol VL - 22 IS - 2 N2 - Seminal vesicle involvement at the time of radical prostatectomy (RP) for prostate cancer has been equated with metastatic disease. We review our biochemical freedom from disease results following RP in patients with seminal vesicle involvement with particular attention to identifying variables that may be predictive of disease recurrence. We retrospectively reviewed our surgical database and identified patients with pT3b (2002 AJCC) prostate cancer at RP [corrected]. There were 70 cases without lymph node involvement and with available clinical follow-up identified. Any patient receiving androgen deprivation therapy, radiation therapy, or with a sustained PSA elevation greater than 0.2 ng/mL was considered a biochemical failure. Results were calculated using the Kaplan-Meier method. Mean age was 63.4 (range 45.7-79.5) years, mean preoperative PSA was 11.3 ng/mL (range 2-60), mean biopsy Gleason score was 7.2 (range 4-9), mean RP Gleason score was 7.5 (range 5-9), and median follow-up time was 61.5 months (range 2.3-160.6). Overall, 33/70 (47%) patients were without evidence of disease without further therapy. For patients with pT3bN0Mx prostate cancer, margin status, capsular invasion, and PSA were not statistically significant risk factors for disease progression. Gleason score and major Gleason grade were the only statistically significant variables that predicted disease progression. A specimen Gleason score of greater than 7 and major Gleason grades greater than 3 were associated with an increased rate of disease progression in this patient group. SN - 1078-1439 UR - https://www.unboundmedicine.com/medline/citation/15082006/Prognostic_indicators_for_long_term_outcome_following_radical_retropubic_prostatectomy_for_prostate_cancer_involving_the_seminal_vesicles_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓3]

Related Citations

More