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Steroids, non-steroidal anti-inflammatory drugs, and sigmoid diverticular abscess perforation in rheumatic conditions.
Ann Rheum Dis. 2004 May; 63(5):588-90.AR

Abstract

BACKGROUND

Corticosteroids and non-steroidal anti-inflammatory drugs are widely used for the treatment of rheumatic conditions, but their gastrointestinal damage significantly limits their use. Sigmoid diverticular abscess perforation (SDAP) is a very serious complication of diverticular disease.

OBJECTIVE

To determine the aetiology of large bowel SDAP in rheumatic conditions.

METHODS

64 patients with SPAD and 320 controls from a similar geographical area and of similar socioeconomic status were studied.

RESULTS

The results showed that independently of rheumatic diagnosis corticosteroid treatment is strongly associated with SDAP (OR 31.9 (95% CI 6.4 to 159.2; p<0.001), and non-steroidal anti-inflammatory drugs only weakly associated (OR 1.8 (95% CI 0.96 to 3.4); p = 0.069). A rheumatic diagnosis is also strongly associated with the development of SDAP (OR 3.5 (95% CI 1.9 to 6.7); p<0.001).

CONCLUSIONS

SDAP has serious implications for patients and consumes many healthcare resources. Patients and physicians should be warned of this potential complication.

Authors+Show Affiliations

Academic Rheumatology Unit, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK. smpofu@liv.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15082493

Citation

Mpofu, S, et al. "Steroids, Non-steroidal Anti-inflammatory Drugs, and Sigmoid Diverticular Abscess Perforation in Rheumatic Conditions." Annals of the Rheumatic Diseases, vol. 63, no. 5, 2004, pp. 588-90.
Mpofu S, Mpofu CM, Hutchinson D, et al. Steroids, non-steroidal anti-inflammatory drugs, and sigmoid diverticular abscess perforation in rheumatic conditions. Ann Rheum Dis. 2004;63(5):588-90.
Mpofu, S., Mpofu, C. M., Hutchinson, D., Maier, A. E., Dodd, S. R., & Moots, R. J. (2004). Steroids, non-steroidal anti-inflammatory drugs, and sigmoid diverticular abscess perforation in rheumatic conditions. Annals of the Rheumatic Diseases, 63(5), 588-90.
Mpofu S, et al. Steroids, Non-steroidal Anti-inflammatory Drugs, and Sigmoid Diverticular Abscess Perforation in Rheumatic Conditions. Ann Rheum Dis. 2004;63(5):588-90. PubMed PMID: 15082493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steroids, non-steroidal anti-inflammatory drugs, and sigmoid diverticular abscess perforation in rheumatic conditions. AU - Mpofu,S, AU - Mpofu,C M A, AU - Hutchinson,D, AU - Maier,A E, AU - Dodd,S R, AU - Moots,R J, PY - 2004/4/15/pubmed PY - 2004/6/21/medline PY - 2004/4/15/entrez SP - 588 EP - 90 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 63 IS - 5 N2 - BACKGROUND: Corticosteroids and non-steroidal anti-inflammatory drugs are widely used for the treatment of rheumatic conditions, but their gastrointestinal damage significantly limits their use. Sigmoid diverticular abscess perforation (SDAP) is a very serious complication of diverticular disease. OBJECTIVE: To determine the aetiology of large bowel SDAP in rheumatic conditions. METHODS: 64 patients with SPAD and 320 controls from a similar geographical area and of similar socioeconomic status were studied. RESULTS: The results showed that independently of rheumatic diagnosis corticosteroid treatment is strongly associated with SDAP (OR 31.9 (95% CI 6.4 to 159.2; p<0.001), and non-steroidal anti-inflammatory drugs only weakly associated (OR 1.8 (95% CI 0.96 to 3.4); p = 0.069). A rheumatic diagnosis is also strongly associated with the development of SDAP (OR 3.5 (95% CI 1.9 to 6.7); p<0.001). CONCLUSIONS: SDAP has serious implications for patients and consumes many healthcare resources. Patients and physicians should be warned of this potential complication. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/15082493/Steroids_non_steroidal_anti_inflammatory_drugs_and_sigmoid_diverticular_abscess_perforation_in_rheumatic_conditions_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&amp;pmid=15082493 DB - PRIME DP - Unbound Medicine ER -