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Helicobacter pylori and gastrointestinal symptoms in school children in Russia.
J Gastroenterol Hepatol. 2004 May; 19(5):490-6.JG

Abstract

BACKGROUND AND AIMS

Helicobacter pylori is considered to be the major cause of chronic gastritis and duodenal ulcer disease recurrence in childhood. However, the association between H. pylori and recurrent abdominal pain (RAP) syndrome is still controversial. Therefore, the spectrum of clinical variants of gastrointestinal symptoms associated with H. pylori-positive status was studied in consecutive symptomatic children who were undergoing diagnostic endoscopy.

METHODS

A consecutive series of 225 school children from the Ural area of Russia (mean age 11.1 + 1.4 years, age range 7-15 years) who presented with RAP were investigated using esophagogastroduodenoscopy, including three antral biopsies for histology and polymerase chain reaction. Helicobacter pylori immunoglobulin G antibodies were found using a second-generation enzyme immunoassay. Information about the clinical symptoms was collected using a special questionnaire.

RESULTS

The authors found a high incidence of H. pylori infection (80%) and peptic ulcers (16%) in 225 school children from the Ural area of Russia who were referred for upper gastrointestinal (UGI) endoscopy for chronic abdominal pain. Of the overall 225 symptomatic children who underwent endoscopy, 182 (80,8%) were found to be H. pylori-positive. Duodenal ulcers were detected in 36 H. pylori-positive children. A family history of peptic ulcers was significantly more frequent in the children infected with H. pylori (P < 0.001). Symptom score and duration of symptoms were similar, but night-time pain (P < 0.0001) and fasting pain relieved by food (P < 0.001) were more frequent in the H. pylori-positive children as compared with the H. pylori-negative children.

CONCLUSIONS

The present results provide further evidence for a significant association between H. pylori and some patterns of gastrointestinal symptoms in children who underwent UGI endoscopy in order to exclude an organic cause of severe chronic gastrointestinal disorders.

Authors+Show Affiliations

Children's Republican Hospital, PO Box 4894, Ufa-57, 450057 Russia. emil@ufanet.ruNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15086591

Citation

Nijevitch, Alexander A., and Peter L. Shcherbakov. "Helicobacter Pylori and Gastrointestinal Symptoms in School Children in Russia." Journal of Gastroenterology and Hepatology, vol. 19, no. 5, 2004, pp. 490-6.
Nijevitch AA, Shcherbakov PL. Helicobacter pylori and gastrointestinal symptoms in school children in Russia. J Gastroenterol Hepatol. 2004;19(5):490-6.
Nijevitch, A. A., & Shcherbakov, P. L. (2004). Helicobacter pylori and gastrointestinal symptoms in school children in Russia. Journal of Gastroenterology and Hepatology, 19(5), 490-6.
Nijevitch AA, Shcherbakov PL. Helicobacter Pylori and Gastrointestinal Symptoms in School Children in Russia. J Gastroenterol Hepatol. 2004;19(5):490-6. PubMed PMID: 15086591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori and gastrointestinal symptoms in school children in Russia. AU - Nijevitch,Alexander A, AU - Shcherbakov,Peter L, PY - 2004/4/17/pubmed PY - 2004/9/3/medline PY - 2004/4/17/entrez SP - 490 EP - 6 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 19 IS - 5 N2 - BACKGROUND AND AIMS: Helicobacter pylori is considered to be the major cause of chronic gastritis and duodenal ulcer disease recurrence in childhood. However, the association between H. pylori and recurrent abdominal pain (RAP) syndrome is still controversial. Therefore, the spectrum of clinical variants of gastrointestinal symptoms associated with H. pylori-positive status was studied in consecutive symptomatic children who were undergoing diagnostic endoscopy. METHODS: A consecutive series of 225 school children from the Ural area of Russia (mean age 11.1 + 1.4 years, age range 7-15 years) who presented with RAP were investigated using esophagogastroduodenoscopy, including three antral biopsies for histology and polymerase chain reaction. Helicobacter pylori immunoglobulin G antibodies were found using a second-generation enzyme immunoassay. Information about the clinical symptoms was collected using a special questionnaire. RESULTS: The authors found a high incidence of H. pylori infection (80%) and peptic ulcers (16%) in 225 school children from the Ural area of Russia who were referred for upper gastrointestinal (UGI) endoscopy for chronic abdominal pain. Of the overall 225 symptomatic children who underwent endoscopy, 182 (80,8%) were found to be H. pylori-positive. Duodenal ulcers were detected in 36 H. pylori-positive children. A family history of peptic ulcers was significantly more frequent in the children infected with H. pylori (P < 0.001). Symptom score and duration of symptoms were similar, but night-time pain (P < 0.0001) and fasting pain relieved by food (P < 0.001) were more frequent in the H. pylori-positive children as compared with the H. pylori-negative children. CONCLUSIONS: The present results provide further evidence for a significant association between H. pylori and some patterns of gastrointestinal symptoms in children who underwent UGI endoscopy in order to exclude an organic cause of severe chronic gastrointestinal disorders. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/15086591/Helicobacter_pylori_and_gastrointestinal_symptoms_in_school_children_in_Russia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0815-9319&amp;date=2004&amp;volume=19&amp;issue=5&amp;spage=490 DB - PRIME DP - Unbound Medicine ER -