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Nonalcoholic fatty liver disease: is all the fat bad?
Intern Med J. 2004 Apr; 34(4):187-91.IM

Abstract

Nonalcoholic fatty liver disease is now a major cause of liver disease in developed countries, largely as a result of an epidemic of obesity, diabetes and sedentary lifestyles. This has resulted in raised clinical awareness and diagnostic refinement. The entity encompasses several histologic patterns from benign steatosis to nonalcoholic steatohepatitis, the latter having a significant risk of progressive fibrosis and the development of cirrhosis. Laboratory tests and imaging are not able to distinguish steatosis from steatohepatitis, which requires liver biopsy. However following an assessment of several risk factors, patients can be stratified for the potential risk of fibrosis, allowing the rational use of liver biopsy. This review will describe the various patterns of nonalcoholic fatty liver disease and relate this to disease pathogenesis and progression. Strategies for management, including experimental interventions, will be discussed.

Authors+Show Affiliations

Sullivan Nicolaides Pathology, University of Queensland, Brisbane, Queensland, Australia. Andrew.Clouston@maynegroup.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15086699

Citation

Clouston, A D., and E E. Powell. "Nonalcoholic Fatty Liver Disease: Is All the Fat Bad?" Internal Medicine Journal, vol. 34, no. 4, 2004, pp. 187-91.
Clouston AD, Powell EE. Nonalcoholic fatty liver disease: is all the fat bad? Intern Med J. 2004;34(4):187-91.
Clouston, A. D., & Powell, E. E. (2004). Nonalcoholic fatty liver disease: is all the fat bad? Internal Medicine Journal, 34(4), 187-91.
Clouston AD, Powell EE. Nonalcoholic Fatty Liver Disease: Is All the Fat Bad. Intern Med J. 2004;34(4):187-91. PubMed PMID: 15086699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic fatty liver disease: is all the fat bad? AU - Clouston,A D, AU - Powell,E E, PY - 2004/4/17/pubmed PY - 2004/10/1/medline PY - 2004/4/17/entrez SP - 187 EP - 91 JF - Internal medicine journal JO - Intern Med J VL - 34 IS - 4 N2 - Nonalcoholic fatty liver disease is now a major cause of liver disease in developed countries, largely as a result of an epidemic of obesity, diabetes and sedentary lifestyles. This has resulted in raised clinical awareness and diagnostic refinement. The entity encompasses several histologic patterns from benign steatosis to nonalcoholic steatohepatitis, the latter having a significant risk of progressive fibrosis and the development of cirrhosis. Laboratory tests and imaging are not able to distinguish steatosis from steatohepatitis, which requires liver biopsy. However following an assessment of several risk factors, patients can be stratified for the potential risk of fibrosis, allowing the rational use of liver biopsy. This review will describe the various patterns of nonalcoholic fatty liver disease and relate this to disease pathogenesis and progression. Strategies for management, including experimental interventions, will be discussed. SN - 1444-0903 UR - https://www.unboundmedicine.com/medline/citation/15086699/Nonalcoholic_fatty_liver_disease:_is_all_the_fat_bad L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1444-0903&date=2004&volume=34&issue=4&spage=187 DB - PRIME DP - Unbound Medicine ER -