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Unusual uveal tract tumor: mesectodermal leiomyoma of the ciliary body.
Pathol Int 2004; 54(5):337-42PI

Abstract

Benign smooth muscle tumor, leiomyoma, can occur throughout the whole body, including the most common sites of the genitourinary and gastrointestinal tracts, less frequently in the skin, and rarely in the deep soft tissue or uveal tract. A 23-year-old Chinese woman presented with a 4 month history of a pigmented ciliary body mass in her left eye. The tumor's clinical appearance and ancillary data were initially consistent with malignant melanoma. However, instead of enucleation, sclerotomy with a tumor biopsy was performed because of the patient's young age and the possibility of benign tumors. Under light microscopy, tumor cells were short spindle- or ovoid-shaped with fine nuclear chromatin and fibrillary cytoplasmic processes resembling neural tissue. Although the tumor displayed neurogenic morphology, it showed strong reactivity for alpha-smooth muscle-specific actin and h-caldesmon, and was negative for neurogenic markers, except CD56, by immunohistochemistry. Primary mesectodermal leiomyoma of the ciliary body was diagnosed because of both the myogenic and neurogenic characteristics. The tumor biopsy or intraoperative frozen section is suggested for accurate pathological diagnosis before enucleation. In a review of the literature, only 14 cases have been reported. Seven cases (50%) were subjected to enucleation and eventually showed a benign mesectodermal leiomyoma. This case report provides novel expression of h-caldesmon and CD56 by the tumor cells of mesectodermal leiomyoma.

Authors+Show Affiliations

Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15086838

Citation

Lai, Chuan-Tsai, et al. "Unusual Uveal Tract Tumor: Mesectodermal Leiomyoma of the Ciliary Body." Pathology International, vol. 54, no. 5, 2004, pp. 337-42.
Lai CT, Tai MC, Liang CM, et al. Unusual uveal tract tumor: mesectodermal leiomyoma of the ciliary body. Pathol Int. 2004;54(5):337-42.
Lai, C. T., Tai, M. C., Liang, C. M., & Lee, H. S. (2004). Unusual uveal tract tumor: mesectodermal leiomyoma of the ciliary body. Pathology International, 54(5), pp. 337-42.
Lai CT, et al. Unusual Uveal Tract Tumor: Mesectodermal Leiomyoma of the Ciliary Body. Pathol Int. 2004;54(5):337-42. PubMed PMID: 15086838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unusual uveal tract tumor: mesectodermal leiomyoma of the ciliary body. AU - Lai,Chuan-Tsai, AU - Tai,Ming-Cheng, AU - Liang,Chang-Min, AU - Lee,Herng-Sheng, PY - 2004/4/17/pubmed PY - 2004/12/16/medline PY - 2004/4/17/entrez SP - 337 EP - 42 JF - Pathology international JO - Pathol. Int. VL - 54 IS - 5 N2 - Benign smooth muscle tumor, leiomyoma, can occur throughout the whole body, including the most common sites of the genitourinary and gastrointestinal tracts, less frequently in the skin, and rarely in the deep soft tissue or uveal tract. A 23-year-old Chinese woman presented with a 4 month history of a pigmented ciliary body mass in her left eye. The tumor's clinical appearance and ancillary data were initially consistent with malignant melanoma. However, instead of enucleation, sclerotomy with a tumor biopsy was performed because of the patient's young age and the possibility of benign tumors. Under light microscopy, tumor cells were short spindle- or ovoid-shaped with fine nuclear chromatin and fibrillary cytoplasmic processes resembling neural tissue. Although the tumor displayed neurogenic morphology, it showed strong reactivity for alpha-smooth muscle-specific actin and h-caldesmon, and was negative for neurogenic markers, except CD56, by immunohistochemistry. Primary mesectodermal leiomyoma of the ciliary body was diagnosed because of both the myogenic and neurogenic characteristics. The tumor biopsy or intraoperative frozen section is suggested for accurate pathological diagnosis before enucleation. In a review of the literature, only 14 cases have been reported. Seven cases (50%) were subjected to enucleation and eventually showed a benign mesectodermal leiomyoma. This case report provides novel expression of h-caldesmon and CD56 by the tumor cells of mesectodermal leiomyoma. SN - 1320-5463 UR - https://www.unboundmedicine.com/medline/citation/15086838/Unusual_uveal_tract_tumor:_mesectodermal_leiomyoma_of_the_ciliary_body_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1320-5463&date=2004&volume=54&issue=5&spage=337 DB - PRIME DP - Unbound Medicine ER -