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Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women.
Arterioscler Thromb Vasc Biol. 2004 Jun; 24(6):1092-7.AT

Abstract

OBJECTIVE

To determine mechanisms contributing to decreased high-density lipoprotein cholesterol (HDL-C) and increased low-density lipoprotein cholesterol (LDL-C) concentrations associated with hydrogenated fat intake, kinetic studies of apoA-I, apoB-100, and apoB-48 were conducted using stable isotopes.

METHODS AND RESULTS

Eight postmenopausal hypercholesterolemic women were provided in random order with 3 diets for 5-week periods. Two-thirds of the fat was soybean oil (unsaturated fat), stick margarine (hydrogenated fat), or butter (saturated fat). Total and LDL-C levels were highest after the saturated diet (P<0.05; saturated versus unsaturated) whereas HDL-C levels were lowest after the hydrogenated diet (P<0.05; hydrogenated versus saturated). Plasma apoA-I levels and pool size (PS) were lower, whereas apoA-I fractional catabolic rate (FCR) was higher after the hydrogenated relative to the saturated diet (P<0.05). LDL apoB-100 levels and PS were significantly higher, whereas LDL apoB-100 FCR was lower with the saturated and hydrogenated relative to the unsaturated diet. There was no significant difference among diets in apoA-I or B-100 production rates or apoB-48 kinetic parameters. HDL-C concentrations were negatively associated with apoA-I FCR (r=-0.56, P=0.03) and LDL-C concentrations were negatively correlated with LDL apoB-100 FCR (r=-0.48, P=0.05).

CONCLUSIONS

The mechanism for the adverse lipoprotein profile observed with hydrogenated fat intake is determined in part by increased apoA-I and decreased LDL apoB-100 catabolism.

Authors+Show Affiliations

Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston Mass 02111, USA. nirupa.matthan@tufts.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15087307

Citation

Matthan, Nirupa R., et al. "Dietary Hydrogenated Fat Increases High-density Lipoprotein apoA-I Catabolism and Decreases Low-density Lipoprotein apoB-100 Catabolism in Hypercholesterolemic Women." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 6, 2004, pp. 1092-7.
Matthan NR, Welty FK, Barrett PH, et al. Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women. Arterioscler Thromb Vasc Biol. 2004;24(6):1092-7.
Matthan, N. R., Welty, F. K., Barrett, P. H., Harausz, C., Dolnikowski, G. G., Parks, J. S., Eckel, R. H., Schaefer, E. J., & Lichtenstein, A. H. (2004). Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(6), 1092-7.
Matthan NR, et al. Dietary Hydrogenated Fat Increases High-density Lipoprotein apoA-I Catabolism and Decreases Low-density Lipoprotein apoB-100 Catabolism in Hypercholesterolemic Women. Arterioscler Thromb Vasc Biol. 2004;24(6):1092-7. PubMed PMID: 15087307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women. AU - Matthan,Nirupa R, AU - Welty,Francine K, AU - Barrett,P Hugh R, AU - Harausz,Carrie, AU - Dolnikowski,Gregory G, AU - Parks,John S, AU - Eckel,Robert H, AU - Schaefer,Ernst J, AU - Lichtenstein,Alice H, Y1 - 2004/04/15/ PY - 2004/4/17/pubmed PY - 2004/11/9/medline PY - 2004/4/17/entrez SP - 1092 EP - 7 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 24 IS - 6 N2 - OBJECTIVE: To determine mechanisms contributing to decreased high-density lipoprotein cholesterol (HDL-C) and increased low-density lipoprotein cholesterol (LDL-C) concentrations associated with hydrogenated fat intake, kinetic studies of apoA-I, apoB-100, and apoB-48 were conducted using stable isotopes. METHODS AND RESULTS: Eight postmenopausal hypercholesterolemic women were provided in random order with 3 diets for 5-week periods. Two-thirds of the fat was soybean oil (unsaturated fat), stick margarine (hydrogenated fat), or butter (saturated fat). Total and LDL-C levels were highest after the saturated diet (P<0.05; saturated versus unsaturated) whereas HDL-C levels were lowest after the hydrogenated diet (P<0.05; hydrogenated versus saturated). Plasma apoA-I levels and pool size (PS) were lower, whereas apoA-I fractional catabolic rate (FCR) was higher after the hydrogenated relative to the saturated diet (P<0.05). LDL apoB-100 levels and PS were significantly higher, whereas LDL apoB-100 FCR was lower with the saturated and hydrogenated relative to the unsaturated diet. There was no significant difference among diets in apoA-I or B-100 production rates or apoB-48 kinetic parameters. HDL-C concentrations were negatively associated with apoA-I FCR (r=-0.56, P=0.03) and LDL-C concentrations were negatively correlated with LDL apoB-100 FCR (r=-0.48, P=0.05). CONCLUSIONS: The mechanism for the adverse lipoprotein profile observed with hydrogenated fat intake is determined in part by increased apoA-I and decreased LDL apoB-100 catabolism. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/15087307/Dietary_hydrogenated_fat_increases_high_density_lipoprotein_apoA_I_catabolism_and_decreases_low_density_lipoprotein_apoB_100_catabolism_in_hypercholesterolemic_women_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000128410.23161.be?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -