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Propofol reduces cognitive impairment after electroconvulsive therapy.
J ECT. 2004 Mar; 20(1):3-9.JE

Abstract

BACKGROUND

Cognitive impairments are the main complication after electroconvulsive therapy (ECT). Modification of treatment parameters has been shown to affect the magnitude of these impairments, but the role of anesthetic type remains unclear. This study tested whether there is a difference in cognitive impairments immediately after ECT with propofol compared to thiopental anesthesia.

METHODS

This randomized, double-blind, crossover study included 15 patients receiving right unilateral ECT for depression. Patients received propofol or thiopental on alternating ECTs up to 6 treatments. Immediate and delayed verbal memory, motor speed, reaction speed, visuospatial, and executive functions were assessed 45 minutes after each ECT. Differences were assessed with repeated measures analysis of variance.

RESULTS

Cognitive impairments were reduced after ECT with propofol compared to thiopental. Time to emergence was quicker and EEG seizure duration was shorter after propofol treatments. There was no significant correlation between seizure duration and neuropsychological test performance.

CONCLUSIONS

Our results indicate that cognitive impairments in the early recovery period after ECT are reduced with propofol compared to thiopental anesthesia. We suggest that, in addition to ECT parameters, the type of anesthetic agent should be considered to reduce cognitive impairments after ECT.

Authors+Show Affiliations

Department of Pharmacology & Therapeutics, Centre for Anesthesia and Analgesia, The University of British Columbia, Vancouver, Canada. noamnb@canada.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15087989

Citation

Butterfield, Noam N., et al. "Propofol Reduces Cognitive Impairment After Electroconvulsive Therapy." The Journal of ECT, vol. 20, no. 1, 2004, pp. 3-9.
Butterfield NN, Graf P, Macleod BA, et al. Propofol reduces cognitive impairment after electroconvulsive therapy. J ECT. 2004;20(1):3-9.
Butterfield, N. N., Graf, P., Macleod, B. A., Ries, C. R., & Zis, A. P. (2004). Propofol reduces cognitive impairment after electroconvulsive therapy. The Journal of ECT, 20(1), 3-9.
Butterfield NN, et al. Propofol Reduces Cognitive Impairment After Electroconvulsive Therapy. J ECT. 2004;20(1):3-9. PubMed PMID: 15087989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propofol reduces cognitive impairment after electroconvulsive therapy. AU - Butterfield,Noam N, AU - Graf,Peter, AU - Macleod,Bernard A, AU - Ries,Craig R, AU - Zis,Athanasios P, PY - 2004/4/17/pubmed PY - 2004/6/24/medline PY - 2004/4/17/entrez SP - 3 EP - 9 JF - The journal of ECT JO - J ECT VL - 20 IS - 1 N2 - BACKGROUND: Cognitive impairments are the main complication after electroconvulsive therapy (ECT). Modification of treatment parameters has been shown to affect the magnitude of these impairments, but the role of anesthetic type remains unclear. This study tested whether there is a difference in cognitive impairments immediately after ECT with propofol compared to thiopental anesthesia. METHODS: This randomized, double-blind, crossover study included 15 patients receiving right unilateral ECT for depression. Patients received propofol or thiopental on alternating ECTs up to 6 treatments. Immediate and delayed verbal memory, motor speed, reaction speed, visuospatial, and executive functions were assessed 45 minutes after each ECT. Differences were assessed with repeated measures analysis of variance. RESULTS: Cognitive impairments were reduced after ECT with propofol compared to thiopental. Time to emergence was quicker and EEG seizure duration was shorter after propofol treatments. There was no significant correlation between seizure duration and neuropsychological test performance. CONCLUSIONS: Our results indicate that cognitive impairments in the early recovery period after ECT are reduced with propofol compared to thiopental anesthesia. We suggest that, in addition to ECT parameters, the type of anesthetic agent should be considered to reduce cognitive impairments after ECT. SN - 1095-0680 UR - https://www.unboundmedicine.com/medline/citation/15087989/Propofol_reduces_cognitive_impairment_after_electroconvulsive_therapy_ L2 - https://doi.org/10.1097/00124509-200403000-00002 DB - PRIME DP - Unbound Medicine ER -