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[Should sex specific differences in venous diseases be explained by pregnancies and hormone intake?].

Abstract

AIM OF THE STUDY

Diseases of the venous system are among the most frequently occurring diseases in the German population. However, the last comprehensive population-based German data were obtained in 1979. Since then, diagnostic methods have improved substantially. Here, we examine the prevalence of venous diseases in women and their association with pregnancies and intake of hormones.

METHODS

We conducted a population-based cross-sectional study in Bonn and rural environments (Recruitment period: 11/2000 - 11/2001; response: 59 %; 3072 study participants (1350 men, 1722 women), 18 to 79 years of age; investigation: standardised medical history, physical examination, duplex sonography, photography and CEAP-classification of veins of the legs). The following definitions were used: 1) Varicosis: clinical classification C2-C6 (primary varicosis only, excluding those showing spider-bursts exclusively); 2) Chronic venous insufficiency (CVI): C3-C6. For women, the risk factors examined were the number of pregnancies (P) and intake of hormones. Odds ratios (OR) and 95 % confidence intervals (95 %-CI) were calculated by multiple logistic regression (adjusted for age, region of residence and socioeconomic status). In addition, never pregnant women and men were compared regarding the two outcome variables.

RESULTS

713 participants (23 %) had varicosis and 522 (17 %) CVI. The OR for women (reference group: men) was OR = 1.4, 95 %-CI: 1.25 - 1.79 (varicosis) and OR = 1.2, 95 %-CI: 0.93 - 1.42 (CVI). There was a positive dose-response relationship between the number of pregnancies and varicosis: 1 P: OR = 1.3 (95 %-CI: 0.89 - 1.96), 2 P: OR = 1.4 (95 %-CI: 1.00 - 2.07), 3 P: OR = 1.6 (95 %-CI: 1.05 - 2.41), 4 P: OR = 1.9 (95 %-CI: 1.18 - 3.20), > or = 5 P: OR = 2.2 (95 %-CI: 1.28 - 3.74) and this trend was similar for CVI. Never-pregnant women (n = 518) and men had a similar prevalence. We did not see a consistent effect of intake of hormones in varicosis (OR = 0.9 [95 %-CI: 0.68 - 1.22]), but a negative association with CVI (OR = 0.6 [95 %-CI: 0.47 - 0.89]).

CONCLUSIONS

Our results confirm the known association between diseases of the venous system and pregnancies, which seem to explain a big share of the sex-specific differences in the prevalence of these diseases.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institut für Medizinische Informatik, Biometrie und Epidemiologie, Universitätsklinikum Essen. katja.bromen@cec.eu.int

    , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Cross-Sectional Studies
    Female
    Germany
    Hormone Replacement Therapy
    Hormones
    Humans
    Male
    Middle Aged
    Pregnancy
    Risk Assessment
    Risk Factors
    Rural Population
    Sex Distribution
    Sex Factors
    Socioeconomic Factors
    Urban Population
    Varicose Veins

    Pub Type(s)

    Clinical Trial
    English Abstract
    Journal Article

    Language

    ger

    PubMed ID

    15088220

    Citation

    Bromen, K, et al. "[Should Sex Specific Differences in Venous Diseases Be Explained By Pregnancies and Hormone Intake?]." Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany)), vol. 66, no. 3, 2004, pp. 170-4.
    Bromen K, Pannier-Fischer F, Stang A, et al. [Should sex specific differences in venous diseases be explained by pregnancies and hormone intake?]. Gesundheitswesen. 2004;66(3):170-4.
    Bromen, K., Pannier-Fischer, F., Stang, A., Rabe, E., Bock, E., & Jöckel, K. H. (2004). [Should sex specific differences in venous diseases be explained by pregnancies and hormone intake?]. Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany)), 66(3), pp. 170-4.
    Bromen K, et al. [Should Sex Specific Differences in Venous Diseases Be Explained By Pregnancies and Hormone Intake?]. Gesundheitswesen. 2004;66(3):170-4. PubMed PMID: 15088220.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Should sex specific differences in venous diseases be explained by pregnancies and hormone intake?]. AU - Bromen,K, AU - Pannier-Fischer,F, AU - Stang,A, AU - Rabe,E, AU - Bock,E, AU - Jöckel,K-H, PY - 2004/4/17/pubmed PY - 2004/8/19/medline PY - 2004/4/17/entrez SP - 170 EP - 4 JF - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) JO - Gesundheitswesen VL - 66 IS - 3 N2 - AIM OF THE STUDY: Diseases of the venous system are among the most frequently occurring diseases in the German population. However, the last comprehensive population-based German data were obtained in 1979. Since then, diagnostic methods have improved substantially. Here, we examine the prevalence of venous diseases in women and their association with pregnancies and intake of hormones. METHODS: We conducted a population-based cross-sectional study in Bonn and rural environments (Recruitment period: 11/2000 - 11/2001; response: 59 %; 3072 study participants (1350 men, 1722 women), 18 to 79 years of age; investigation: standardised medical history, physical examination, duplex sonography, photography and CEAP-classification of veins of the legs). The following definitions were used: 1) Varicosis: clinical classification C2-C6 (primary varicosis only, excluding those showing spider-bursts exclusively); 2) Chronic venous insufficiency (CVI): C3-C6. For women, the risk factors examined were the number of pregnancies (P) and intake of hormones. Odds ratios (OR) and 95 % confidence intervals (95 %-CI) were calculated by multiple logistic regression (adjusted for age, region of residence and socioeconomic status). In addition, never pregnant women and men were compared regarding the two outcome variables. RESULTS: 713 participants (23 %) had varicosis and 522 (17 %) CVI. The OR for women (reference group: men) was OR = 1.4, 95 %-CI: 1.25 - 1.79 (varicosis) and OR = 1.2, 95 %-CI: 0.93 - 1.42 (CVI). There was a positive dose-response relationship between the number of pregnancies and varicosis: 1 P: OR = 1.3 (95 %-CI: 0.89 - 1.96), 2 P: OR = 1.4 (95 %-CI: 1.00 - 2.07), 3 P: OR = 1.6 (95 %-CI: 1.05 - 2.41), 4 P: OR = 1.9 (95 %-CI: 1.18 - 3.20), > or = 5 P: OR = 2.2 (95 %-CI: 1.28 - 3.74) and this trend was similar for CVI. Never-pregnant women (n = 518) and men had a similar prevalence. We did not see a consistent effect of intake of hormones in varicosis (OR = 0.9 [95 %-CI: 0.68 - 1.22]), but a negative association with CVI (OR = 0.6 [95 %-CI: 0.47 - 0.89]). CONCLUSIONS: Our results confirm the known association between diseases of the venous system and pregnancies, which seem to explain a big share of the sex-specific differences in the prevalence of these diseases. SN - 0941-3790 UR - https://www.unboundmedicine.com/medline/citation/15088220/[Should_sex_specific_differences_in_venous_diseases_be_explained_by_pregnancies_and_hormone_intake]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-813019 DB - PRIME DP - Unbound Medicine ER -