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Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain.
Exp Toxicol Pathol. 2004 Mar; 55(5):379-84.ET

Abstract

Melatonin is an endogenously produced antioxidant with radioprotective actions while ionizing radiation is a well-known cytotoxic and mutagenic agent of which the biological results are attributable to its free radical producing effects. The effect of melatonin on the DNA strand breakage and lipid peroxidation induced by ionizing radiation in the rat brain were investigated in order to clarify its radioprotective ability. The DNA strand breakage in rat brain exposed to 1000 cGy ionizing radiation was assessed by alkaline single cell gel electrophoresis and the lipid peroxidation was evaluated by measuring thiobarbituric acid reactive substances (TBARS) concentrations. A significant increase in DNA damage (p < 0.05) and TBARS concentrations (p < 0.01) was found in the radiation treated rat brain. Pre-treatment of rats with intraperitoneal doses of 100 mg/kg melatonin provided a significant decrease in the DNA strand breakage and lipid peroxidation. Our results indicate that melatonin can protect brain cells from oxidative damage induced by ionizing radiation.

Authors+Show Affiliations

Undeger U
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Giray B
No affiliation info available
Zorlu AF
No affiliation info available
Oge K
No affiliation info available
Baçaran N
No affiliation info available

MeSH

AnimalsAntioxidantsBrainComet AssayDNA DamageFemaleLipid PeroxidationMelatoninRadiation, IonizingRatsRats, WistarThiobarbituric Acid Reactive Substances

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15088639

Citation

Undeger, Ulko, et al. "Protective Effects of Melatonin On the Ionizing Radiation Induced DNA Damage in the Rat Brain." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 55, no. 5, 2004, pp. 379-84.
Undeger U, Giray B, Zorlu AF, et al. Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain. Exp Toxicol Pathol. 2004;55(5):379-84.
Undeger, U., Giray, B., Zorlu, A. F., Oge, K., & Baçaran, N. (2004). Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 55(5), 379-84.
Undeger U, et al. Protective Effects of Melatonin On the Ionizing Radiation Induced DNA Damage in the Rat Brain. Exp Toxicol Pathol. 2004;55(5):379-84. PubMed PMID: 15088639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain. AU - Undeger,Ulko, AU - Giray,Belma, AU - Zorlu,A Faruk, AU - Oge,Kamil, AU - Baçaran,Nurçen, PY - 2004/4/20/pubmed PY - 2004/10/16/medline PY - 2004/4/20/entrez SP - 379 EP - 84 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp Toxicol Pathol VL - 55 IS - 5 N2 - Melatonin is an endogenously produced antioxidant with radioprotective actions while ionizing radiation is a well-known cytotoxic and mutagenic agent of which the biological results are attributable to its free radical producing effects. The effect of melatonin on the DNA strand breakage and lipid peroxidation induced by ionizing radiation in the rat brain were investigated in order to clarify its radioprotective ability. The DNA strand breakage in rat brain exposed to 1000 cGy ionizing radiation was assessed by alkaline single cell gel electrophoresis and the lipid peroxidation was evaluated by measuring thiobarbituric acid reactive substances (TBARS) concentrations. A significant increase in DNA damage (p < 0.05) and TBARS concentrations (p < 0.01) was found in the radiation treated rat brain. Pre-treatment of rats with intraperitoneal doses of 100 mg/kg melatonin provided a significant decrease in the DNA strand breakage and lipid peroxidation. Our results indicate that melatonin can protect brain cells from oxidative damage induced by ionizing radiation. SN - 0940-2993 UR - https://www.unboundmedicine.com/medline/citation/15088639/Protective_effects_of_melatonin_on_the_ionizing_radiation_induced_DNA_damage_in_the_rat_brain_ DB - PRIME DP - Unbound Medicine ER -