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Heterotopic ossification.
J Am Acad Orthop Surg. 2004 Mar-Apr; 12(2):116-25.JA

Abstract

Heterotopic ossification, the formation of bone in soft tissue, requires inductive signaling pathways, inducible osteoprogenitor cells, and a heterotopic environment conducive to osteogenesis. Little is known about the molecular pathogenesis of this condition. Research into two rare heritable and developmental forms, fibrodysplasia ossificans progressiva and progressive osseous heteroplasia, has provided clinical, pathologic, and genetic insights. In fibrodysplasia ossificans progressiva, overexpression of bone morphogenetic protein 4 and underexpression of multiple antagonists of this protein highlight the potential role of a potent morphogenetic gradient. Research on fibrodysplasia ossificans progressiva also has led to the identification of the genetic cause of progressive osseous heteroplasia: inactivating mutations in the alpha subunit of the gene coding for the stimulatory G protein of adenylyl cyclase. Better understanding of the complex developmental and molecular pathology of these disorders may lead to more effective strategies to prevent and treat other, more common forms of heterotopic ossification.

Authors+Show Affiliations

Departments of Orthopaedic Surgery and Medicine, The University of Pennsylvania School of Medicine, Silverstein 2, 3400 Spruce Street, Philadelphia, PA 19104-5283, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15089085

Citation

Kaplan, Frederick S., et al. "Heterotopic Ossification." The Journal of the American Academy of Orthopaedic Surgeons, vol. 12, no. 2, 2004, pp. 116-25.
Kaplan FS, Glaser DL, Hebela N, et al. Heterotopic ossification. J Am Acad Orthop Surg. 2004;12(2):116-25.
Kaplan, F. S., Glaser, D. L., Hebela, N., & Shore, E. M. (2004). Heterotopic ossification. The Journal of the American Academy of Orthopaedic Surgeons, 12(2), 116-25.
Kaplan FS, et al. Heterotopic Ossification. J Am Acad Orthop Surg. 2004 Mar-Apr;12(2):116-25. PubMed PMID: 15089085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heterotopic ossification. AU - Kaplan,Frederick S, AU - Glaser,David L, AU - Hebela,Nader, AU - Shore,Eileen M, PY - 2004/4/20/pubmed PY - 2004/7/14/medline PY - 2004/4/20/entrez SP - 116 EP - 25 JF - The Journal of the American Academy of Orthopaedic Surgeons JO - J Am Acad Orthop Surg VL - 12 IS - 2 N2 - Heterotopic ossification, the formation of bone in soft tissue, requires inductive signaling pathways, inducible osteoprogenitor cells, and a heterotopic environment conducive to osteogenesis. Little is known about the molecular pathogenesis of this condition. Research into two rare heritable and developmental forms, fibrodysplasia ossificans progressiva and progressive osseous heteroplasia, has provided clinical, pathologic, and genetic insights. In fibrodysplasia ossificans progressiva, overexpression of bone morphogenetic protein 4 and underexpression of multiple antagonists of this protein highlight the potential role of a potent morphogenetic gradient. Research on fibrodysplasia ossificans progressiva also has led to the identification of the genetic cause of progressive osseous heteroplasia: inactivating mutations in the alpha subunit of the gene coding for the stimulatory G protein of adenylyl cyclase. Better understanding of the complex developmental and molecular pathology of these disorders may lead to more effective strategies to prevent and treat other, more common forms of heterotopic ossification. SN - 1067-151X UR - https://www.unboundmedicine.com/medline/citation/15089085/Heterotopic_ossification_ L2 - http://dx.doi.org/10.5435/00124635-200403000-00007 DB - PRIME DP - Unbound Medicine ER -