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Effect of PI-HAART on the prevalence of oral lesions in HIV-1 infected patients. A Greek study.
Oral Dis. 2004 May; 10(3):145-50.OD

Abstract

OBJECTIVE

To investigate the association between the prevalence of oral lesions and highly active antiretroviral therapy (HAART) including a protease inhibitor (PI).

DESIGN

Prospective study.

PATIENTS AND METHODS

Ninety-five consecutive patients, attending an AIDS Unit, in Greece entered the study. Fourty-four patients were receiving PI- HAART, 14 patients were on double antiretroviral therapy, and 37 patients were not receiving antiretroviral therapy at the time of oral examination. Oral lesions were diagnosed by established presumptive clinical criteria.

MAIN OUTCOME MEASURES

Oral lesions were scored. CD4 counts and viral load were determined and related to the prevalence of oral lesions.

RESULTS

Oral lesions, and specifically oral candidiasis, were significantly reduced (P < 0.001) in patients receiving PI-HAART. Oral lesions were significantly increased in patients with CD4 counts <200 cells microl(-1) and viral load >20,000 copies ml(-1) (P < 0.001). The percentage of patients, with lesions on PI-HAART, and with CD4 < 200 and viral load >20,000 was 1.5 times lower (37.5%vs 58.8%, P < 0.001) than that of patients not receiving antiretroviral therapy, but with similar immune and viremic status.

CONCLUSIONS

Oral lesions were significantly reduced in patients on PI-HAART. A direct anticandidal effect of PI was suggestive and seemed to have accounted, beyond the HAART-related immune reconstitution, for the reduction of candidiasis and all other oral lesions.

Authors+Show Affiliations

Nicolatou-Galitis O
Department of Oral Pathology and Oral Medicine, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece. nicolatou.galitis@lycos.com
Velegraki A
No affiliation info available
Paikos S
No affiliation info available
Economopoulou P
No affiliation info available
Stefaniotis T
No affiliation info available
Papanikolaou IS
No affiliation info available
Kordossis T
No affiliation info available

MeSH

AdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCandidiasis, OralFemaleFollow-Up StudiesGreeceHIV InfectionsHIV Protease InhibitorsHIV-1HumansLeukoplakia, HairyMaleMouth DiseasesProspective StudiesReverse Transcriptase InhibitorsViral Load

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15089923

Citation

Nicolatou-Galitis, O, et al. "Effect of PI-HAART On the Prevalence of Oral Lesions in HIV-1 Infected Patients. a Greek Study." Oral Diseases, vol. 10, no. 3, 2004, pp. 145-50.
Nicolatou-Galitis O, Velegraki A, Paikos S, et al. Effect of PI-HAART on the prevalence of oral lesions in HIV-1 infected patients. A Greek study. Oral Dis. 2004;10(3):145-50.
Nicolatou-Galitis, O., Velegraki, A., Paikos, S., Economopoulou, P., Stefaniotis, T., Papanikolaou, I. S., & Kordossis, T. (2004). Effect of PI-HAART on the prevalence of oral lesions in HIV-1 infected patients. A Greek study. Oral Diseases, 10(3), 145-50.
Nicolatou-Galitis O, et al. Effect of PI-HAART On the Prevalence of Oral Lesions in HIV-1 Infected Patients. a Greek Study. Oral Dis. 2004;10(3):145-50. PubMed PMID: 15089923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of PI-HAART on the prevalence of oral lesions in HIV-1 infected patients. A Greek study. AU - Nicolatou-Galitis,O, AU - Velegraki,A, AU - Paikos,S, AU - Economopoulou,P, AU - Stefaniotis,T, AU - Papanikolaou,I S, AU - Kordossis,T, PY - 2004/4/20/pubmed PY - 2004/5/27/medline PY - 2004/4/20/entrez SP - 145 EP - 50 JF - Oral diseases JO - Oral Dis VL - 10 IS - 3 N2 - OBJECTIVE: To investigate the association between the prevalence of oral lesions and highly active antiretroviral therapy (HAART) including a protease inhibitor (PI). DESIGN: Prospective study. PATIENTS AND METHODS: Ninety-five consecutive patients, attending an AIDS Unit, in Greece entered the study. Fourty-four patients were receiving PI- HAART, 14 patients were on double antiretroviral therapy, and 37 patients were not receiving antiretroviral therapy at the time of oral examination. Oral lesions were diagnosed by established presumptive clinical criteria. MAIN OUTCOME MEASURES: Oral lesions were scored. CD4 counts and viral load were determined and related to the prevalence of oral lesions. RESULTS: Oral lesions, and specifically oral candidiasis, were significantly reduced (P < 0.001) in patients receiving PI-HAART. Oral lesions were significantly increased in patients with CD4 counts <200 cells microl(-1) and viral load >20,000 copies ml(-1) (P < 0.001). The percentage of patients, with lesions on PI-HAART, and with CD4 < 200 and viral load >20,000 was 1.5 times lower (37.5%vs 58.8%, P < 0.001) than that of patients not receiving antiretroviral therapy, but with similar immune and viremic status. CONCLUSIONS: Oral lesions were significantly reduced in patients on PI-HAART. A direct anticandidal effect of PI was suggestive and seemed to have accounted, beyond the HAART-related immune reconstitution, for the reduction of candidiasis and all other oral lesions. SN - 1354-523X UR - https://www.unboundmedicine.com/medline/citation/15089923/Effect_of_PI_HAART_on_the_prevalence_of_oral_lesions_in_HIV_1_infected_patients__A_Greek_study_ DB - PRIME DP - Unbound Medicine ER -