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Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime) alone for the treatment of cutaneous leishmaniasis.
Int J Dermatol. 2004 Apr; 43(4):281-3.IJ

Abstract

BACKGROUND

Cutaneous leishmaniasis (CL) is a parasitic disease caused by Leishmania species. There is a need for more effective and less time-consuming therapeutic methods for this condition.

AIM

To evaluate the efficacy of combined cryotherapy and intralesional meglumine antimoniate (MA) (Glucantime, Specia, Paris, France) for the treatment of CL.

METHODS

Patients were divided into three groups: Group 1, 100 patients with 149 lesions were treated with cryotherapy plus intralesional MA; Group 2, 200 patients with 230 lesions were treated with cryotherapy; Group 3, 100 patients with 160 lesions were treated with intralesional MA. These groups were followed for 6 months after the end of treatment.

RESULTS

The results showed complete cure in 90.9% of cases in Group 1, 57.15% of cases in Group 2, and 55.63% of cases in Group 3. The difference between Group 1 and the other groups was statistically significant (P < 0.05).

CONCLUSIONS

Combined cryotherapy and intralesional MA is more effective than either cryotherapy or intralesional MA alone for the treatment of CL.

Authors+Show Affiliations

Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15090013

Citation

Asilian, A, et al. "Comparative Study of the Efficacy of Combined Cryotherapy and Intralesional Meglumine Antimoniate (Glucantime) Vs. Cryotherapy and Intralesional Meglumine Antimoniate (Glucantime) Alone for the Treatment of Cutaneous Leishmaniasis." International Journal of Dermatology, vol. 43, no. 4, 2004, pp. 281-3.
Asilian A, Sadeghinia A, Faghihi G, et al. Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime) alone for the treatment of cutaneous leishmaniasis. Int J Dermatol. 2004;43(4):281-3.
Asilian, A., Sadeghinia, A., Faghihi, G., & Momeni, A. (2004). Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime) alone for the treatment of cutaneous leishmaniasis. International Journal of Dermatology, 43(4), 281-3.
Asilian A, et al. Comparative Study of the Efficacy of Combined Cryotherapy and Intralesional Meglumine Antimoniate (Glucantime) Vs. Cryotherapy and Intralesional Meglumine Antimoniate (Glucantime) Alone for the Treatment of Cutaneous Leishmaniasis. Int J Dermatol. 2004;43(4):281-3. PubMed PMID: 15090013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime) alone for the treatment of cutaneous leishmaniasis. AU - Asilian,A, AU - Sadeghinia,A, AU - Faghihi,G, AU - Momeni,A, PY - 2004/4/20/pubmed PY - 2004/9/3/medline PY - 2004/4/20/entrez SP - 281 EP - 3 JF - International journal of dermatology JO - Int J Dermatol VL - 43 IS - 4 N2 - BACKGROUND: Cutaneous leishmaniasis (CL) is a parasitic disease caused by Leishmania species. There is a need for more effective and less time-consuming therapeutic methods for this condition. AIM: To evaluate the efficacy of combined cryotherapy and intralesional meglumine antimoniate (MA) (Glucantime, Specia, Paris, France) for the treatment of CL. METHODS: Patients were divided into three groups: Group 1, 100 patients with 149 lesions were treated with cryotherapy plus intralesional MA; Group 2, 200 patients with 230 lesions were treated with cryotherapy; Group 3, 100 patients with 160 lesions were treated with intralesional MA. These groups were followed for 6 months after the end of treatment. RESULTS: The results showed complete cure in 90.9% of cases in Group 1, 57.15% of cases in Group 2, and 55.63% of cases in Group 3. The difference between Group 1 and the other groups was statistically significant (P < 0.05). CONCLUSIONS: Combined cryotherapy and intralesional MA is more effective than either cryotherapy or intralesional MA alone for the treatment of CL. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/15090013/Comparative_study_of_the_efficacy_of_combined_cryotherapy_and_intralesional_meglumine_antimoniate__Glucantime__vs__cryotherapy_and_intralesional_meglumine_antimoniate__Glucantime__alone_for_the_treatment_of_cutaneous_leishmaniasis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0011-9059&amp;date=2004&amp;volume=43&amp;issue=4&amp;spage=281 DB - PRIME DP - Unbound Medicine ER -