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Natural history of decompensated hepatitis C virus-related cirrhosis. A study of 200 patients.
J Hepatol. 2004 May; 40(5):823-30.JH

Abstract

BACKGROUND/AIMS

Since few data are available concerning the clinical course of decompensated hepatitis C virus (HCV)-related cirrhosis, the aim of the present study was to define the natural long-term course after the first hepatic decompensation.

METHODS

Cohort of 200 consecutive patients with HCV-related cirrhosis, and without known hepatocellular carcinoma (HCC), hospitalized for the first hepatic decompensation.

RESULTS

Ascites was the most frequent first decompensation (48%), followed by portal hypertensive gastrointestinal bleeding (PHGB) (32.5%), severe bacterial infection (BI) (14.5%) and hepatic encephalopathy (HE) (5%). During follow-up (34+/-2 months) there were 519 readmissions, HCC developed in 33 (16.5%) patients, and death occurred in 85 patients (42.5%). The probability of survival after diagnosis of decompensated cirrhosis was 81.8 and 50.8% at 1 and 5 years, respectively. HE and/or ascites as the first hepatic decompensation, baseline Child-Pugh score, age, and presence of more than one decompensation during follow-up were independently correlated with survival.

CONCLUSIONS

Once decompensated HCV-related cirrhosis was established, patients showed not only a very high frequency of readmissions, but also developed decompensations different from the initial one. These results contribute to defining the natural course and prognosis of decompensated HCV-related cirrhosis.

Authors+Show Affiliations

Planas R
Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Universitat Autónoma de Barcelona, Badalona, Spain. rplanas@ns.hugtip.scs.es
Ballesté B
No affiliation info available
Alvarez MA
No affiliation info available
Rivera M
No affiliation info available
Montoliu S
No affiliation info available
Galeras JA
No affiliation info available
Santos J
No affiliation info available
Coll S
No affiliation info available
Morillas RM
No affiliation info available
Solà R
No affiliation info available

MeSH

AdultAgedAged, 80 and overAscitesBacterial InfectionsCarcinoma, HepatocellularFemaleGastrointestinal HemorrhageHepatic EncephalopathyHepatitis C, ChronicHumansHypertension, PortalLiver CirrhosisLiver NeoplasmsMaleMiddle AgedPrognosisSurvival Rate

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15094231

Citation

Planas, Ramon, et al. "Natural History of Decompensated Hepatitis C Virus-related Cirrhosis. a Study of 200 Patients." Journal of Hepatology, vol. 40, no. 5, 2004, pp. 823-30.
Planas R, Ballesté B, Alvarez MA, et al. Natural history of decompensated hepatitis C virus-related cirrhosis. A study of 200 patients. J Hepatol. 2004;40(5):823-30.
Planas, R., Ballesté, B., Alvarez, M. A., Rivera, M., Montoliu, S., Galeras, J. A., Santos, J., Coll, S., Morillas, R. M., & Solà, R. (2004). Natural history of decompensated hepatitis C virus-related cirrhosis. A study of 200 patients. Journal of Hepatology, 40(5), 823-30.
Planas R, et al. Natural History of Decompensated Hepatitis C Virus-related Cirrhosis. a Study of 200 Patients. J Hepatol. 2004;40(5):823-30. PubMed PMID: 15094231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Natural history of decompensated hepatitis C virus-related cirrhosis. A study of 200 patients. AU - Planas,Ramon, AU - Ballesté,Belén, AU - Alvarez,Marco Antonio, AU - Rivera,Monica, AU - Montoliu,Silvia, AU - Galeras,Josep Anton, AU - Santos,Justiniano, AU - Coll,Susanna, AU - Morillas,Rosa Maria, AU - Solà,Ricard, PY - 2003/08/13/received PY - 2003/12/29/revised PY - 2004/01/07/accepted PY - 2004/4/20/pubmed PY - 2004/12/16/medline PY - 2004/4/20/entrez SP - 823 EP - 30 JF - Journal of hepatology JO - J Hepatol VL - 40 IS - 5 N2 - BACKGROUND/AIMS: Since few data are available concerning the clinical course of decompensated hepatitis C virus (HCV)-related cirrhosis, the aim of the present study was to define the natural long-term course after the first hepatic decompensation. METHODS: Cohort of 200 consecutive patients with HCV-related cirrhosis, and without known hepatocellular carcinoma (HCC), hospitalized for the first hepatic decompensation. RESULTS: Ascites was the most frequent first decompensation (48%), followed by portal hypertensive gastrointestinal bleeding (PHGB) (32.5%), severe bacterial infection (BI) (14.5%) and hepatic encephalopathy (HE) (5%). During follow-up (34+/-2 months) there were 519 readmissions, HCC developed in 33 (16.5%) patients, and death occurred in 85 patients (42.5%). The probability of survival after diagnosis of decompensated cirrhosis was 81.8 and 50.8% at 1 and 5 years, respectively. HE and/or ascites as the first hepatic decompensation, baseline Child-Pugh score, age, and presence of more than one decompensation during follow-up were independently correlated with survival. CONCLUSIONS: Once decompensated HCV-related cirrhosis was established, patients showed not only a very high frequency of readmissions, but also developed decompensations different from the initial one. These results contribute to defining the natural course and prognosis of decompensated HCV-related cirrhosis. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/15094231/Natural_history_of_decompensated_hepatitis_C_virus_related_cirrhosis__A_study_of_200_patients_ DB - PRIME DP - Unbound Medicine ER -