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Factors associated with liver steatosis and fibrosis in chronic hepatitis C patients.
Gastroenterol Clin Biol 2004; 28(3):272-8GC

Abstract

Liver steatosis is a common finding in patients infected with hepatitis C virus (HCV). Host and viral factors have been associated with steatosis, but their relative contributions have not been clearly addressed. It has been suggested that steatosis plays a role in the progression of liver fibrosis.

AIMS

To assess: a) factors associated with steatosis in patients infected with hepatitis C virus; b) their impact on liver fibrosis.

PATIENTS AND METHODS

Three hundred and fourteen untreated patients were included. Lifetime alcohol consumption was estimated. Liver fibrosis, inflammation and necrosis were assessed using the METAVIR score. Body mass index (BMI) was determined. The scoring system for steatosis was as follows: 0, no steatosis; 1, less than 10%; 2, 10% to 30%; 3, 30% to 70%; 4, more than 70% of hepatocytes affected.

RESULTS

In univariate analysis, steatosis was associated with elevated BMI (P=0.001), excessive alcohol intake (P=0.005), genotype 3 (P<0.001) and moderate to severe histological activity (P=0.01). Multivariate analysis showed that steatosis correlated with two independent factors: genotype 3a (OR=60.7; 95% CI: 7.6-483.4) (P<0.001) and BMI (OR=4.86; 95% CI: 1.8-13.15) (P=0.002). In univariate analysis, severe fibrosis (F2-F3-F4) was associated with older age (P<10(-5)), male gender (P=0.001), disease duration (P<0.006), BMI (P<10(-4)), alcohol intake (P<10(-6)), severity of histological activity (P<10(-5)) and steatosis (P<10(-6)). In multivariate analysis, three independent factors were associated with severe fibrosis: disease duration > 10 years (OR=3.17; 95% CI: 0.65-15.4) (P=0.015), presence of steatosis (OR=3.17; 95% CI: 1-9.99) (P<0.049) and genotype 3a (OR=5.56; 95% CI: 1.4-22.1) (P=0.015).

CONCLUSION

In patients with chronic hepatitis C, steatosis is significantly associated with genotype 3 infection and high BMI. Steatosis is an independent risk factor associated with severe fibrosis. These results have major implications for the management of patients with chronic hepatitis C.

Authors+Show Affiliations

Service d'Hépato-Gastroentérologie, CHU La Cavale Blanche 29609 Brest Cedex.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15094677

Citation

Cholet, Franck, et al. "Factors Associated With Liver Steatosis and Fibrosis in Chronic Hepatitis C Patients." Gastroenterologie Clinique Et Biologique, vol. 28, no. 3, 2004, pp. 272-8.
Cholet F, Nousbaum JB, Richecoeur M, et al. Factors associated with liver steatosis and fibrosis in chronic hepatitis C patients. Gastroenterol Clin Biol. 2004;28(3):272-8.
Cholet, F., Nousbaum, J. B., Richecoeur, M., Oger, E., Cauvin, J. M., Lagarde, N., ... Gouérou, H. (2004). Factors associated with liver steatosis and fibrosis in chronic hepatitis C patients. Gastroenterologie Clinique Et Biologique, 28(3), pp. 272-8.
Cholet F, et al. Factors Associated With Liver Steatosis and Fibrosis in Chronic Hepatitis C Patients. Gastroenterol Clin Biol. 2004;28(3):272-8. PubMed PMID: 15094677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with liver steatosis and fibrosis in chronic hepatitis C patients. AU - Cholet,Franck, AU - Nousbaum,Jean-Baptiste, AU - Richecoeur,Martial, AU - Oger,Emmanuel, AU - Cauvin,Jean-Michel, AU - Lagarde,Nicole, AU - Robaszkiewicz,Michel, AU - Gouérou,Hervé, PY - 2004/4/20/pubmed PY - 2004/5/28/medline PY - 2004/4/20/entrez SP - 272 EP - 8 JF - Gastroenterologie clinique et biologique JO - Gastroenterol. Clin. Biol. VL - 28 IS - 3 N2 - UNLABELLED: Liver steatosis is a common finding in patients infected with hepatitis C virus (HCV). Host and viral factors have been associated with steatosis, but their relative contributions have not been clearly addressed. It has been suggested that steatosis plays a role in the progression of liver fibrosis. AIMS: To assess: a) factors associated with steatosis in patients infected with hepatitis C virus; b) their impact on liver fibrosis. PATIENTS AND METHODS: Three hundred and fourteen untreated patients were included. Lifetime alcohol consumption was estimated. Liver fibrosis, inflammation and necrosis were assessed using the METAVIR score. Body mass index (BMI) was determined. The scoring system for steatosis was as follows: 0, no steatosis; 1, less than 10%; 2, 10% to 30%; 3, 30% to 70%; 4, more than 70% of hepatocytes affected. RESULTS: In univariate analysis, steatosis was associated with elevated BMI (P=0.001), excessive alcohol intake (P=0.005), genotype 3 (P<0.001) and moderate to severe histological activity (P=0.01). Multivariate analysis showed that steatosis correlated with two independent factors: genotype 3a (OR=60.7; 95% CI: 7.6-483.4) (P<0.001) and BMI (OR=4.86; 95% CI: 1.8-13.15) (P=0.002). In univariate analysis, severe fibrosis (F2-F3-F4) was associated with older age (P<10(-5)), male gender (P=0.001), disease duration (P<0.006), BMI (P<10(-4)), alcohol intake (P<10(-6)), severity of histological activity (P<10(-5)) and steatosis (P<10(-6)). In multivariate analysis, three independent factors were associated with severe fibrosis: disease duration > 10 years (OR=3.17; 95% CI: 0.65-15.4) (P=0.015), presence of steatosis (OR=3.17; 95% CI: 1-9.99) (P<0.049) and genotype 3a (OR=5.56; 95% CI: 1.4-22.1) (P=0.015). CONCLUSION: In patients with chronic hepatitis C, steatosis is significantly associated with genotype 3 infection and high BMI. Steatosis is an independent risk factor associated with severe fibrosis. These results have major implications for the management of patients with chronic hepatitis C. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/15094677/Factors_associated_with_liver_steatosis_and_fibrosis_in_chronic_hepatitis_C_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/MDOI-GCB-03-2004-28-3-0399-8320-101019-ART12 DB - PRIME DP - Unbound Medicine ER -