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A nationwide survey of deep fungal infections and fungal prophylaxis after hematopoietic stem cell transplantation in Japan.
Bone Marrow Transplant. 2004 Jun; 33(12):1173-9.BM

Abstract

We conducted a nationwide survey to define incidence of deep fungal infections and fungal prophylaxis practices after HSCT. In all, 63 institutions responded. Total number of in-patient transplantations was 935: 367 autologous, 414 allogeneic myeloablative, and 154 allogeneic reduced-intensity (RIST) (n=154). Number of patients who were cared for in a clean room at transplant was 261 (71%) in autologous, 409 (99%) in conventional and 93 (66%) in RIST, respectively. All patients received prophylactic antifungal agents; 89% fluconazole. Number of patients who received the dosage recommended in the CDC guidelines (400 mg/day) was 135 (42%) in conventional transplant and 34 (30%) in RIST (P=0.037). Number of patients who received fluconazole until engraftment and beyond day 75 in conventional transplant vs RIST was, respectively, 324 (100%) vs 109 (97%), and 39 (12%) vs 18 (16%), with no significant difference between the two groups. A total of 37 patients (4.0%) were diagnosed with deep fungal infections; autologous transplantation (0.03%), conventional transplantation (6.0%) and RIST (7.1%). Wide variations in antifungal prophylaxis practice according to the type of transplant and the institutions, and deep fungal infection remain significant problems in RIST.

Authors+Show Affiliations

Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15094754

Citation

Imataki, O, et al. "A Nationwide Survey of Deep Fungal Infections and Fungal Prophylaxis After Hematopoietic Stem Cell Transplantation in Japan." Bone Marrow Transplantation, vol. 33, no. 12, 2004, pp. 1173-9.
Imataki O, Kami M, Kim SW, et al. A nationwide survey of deep fungal infections and fungal prophylaxis after hematopoietic stem cell transplantation in Japan. Bone Marrow Transplant. 2004;33(12):1173-9.
Imataki, O., Kami, M., Kim, S. W., Gotoh, M., Komaba, S., Kasai, M., Hashino, S., Naito, K., Masuda, M., Anan, K., Teshima, H., Togitani, K., Inoue, T., Nishimura, M., Adachi, Y., Fukuhara, T., Yamashita, T., Uike, N., Kobayashi, Y., ... Takaue, Y. (2004). A nationwide survey of deep fungal infections and fungal prophylaxis after hematopoietic stem cell transplantation in Japan. Bone Marrow Transplantation, 33(12), 1173-9.
Imataki O, et al. A Nationwide Survey of Deep Fungal Infections and Fungal Prophylaxis After Hematopoietic Stem Cell Transplantation in Japan. Bone Marrow Transplant. 2004;33(12):1173-9. PubMed PMID: 15094754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A nationwide survey of deep fungal infections and fungal prophylaxis after hematopoietic stem cell transplantation in Japan. AU - Imataki,O, AU - Kami,M, AU - Kim,S-W, AU - Gotoh,M, AU - Komaba,S, AU - Kasai,M, AU - Hashino,S, AU - Naito,K, AU - Masuda,M, AU - Anan,K, AU - Teshima,H, AU - Togitani,K, AU - Inoue,T, AU - Nishimura,M, AU - Adachi,Y, AU - Fukuhara,T, AU - Yamashita,T, AU - Uike,N, AU - Kobayashi,Y, AU - Hamaguchi,M, AU - Higuchi,M, AU - Kawakami,K, AU - Takaue,Y, PY - 2004/4/20/pubmed PY - 2005/2/11/medline PY - 2004/4/20/entrez SP - 1173 EP - 9 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 33 IS - 12 N2 - We conducted a nationwide survey to define incidence of deep fungal infections and fungal prophylaxis practices after HSCT. In all, 63 institutions responded. Total number of in-patient transplantations was 935: 367 autologous, 414 allogeneic myeloablative, and 154 allogeneic reduced-intensity (RIST) (n=154). Number of patients who were cared for in a clean room at transplant was 261 (71%) in autologous, 409 (99%) in conventional and 93 (66%) in RIST, respectively. All patients received prophylactic antifungal agents; 89% fluconazole. Number of patients who received the dosage recommended in the CDC guidelines (400 mg/day) was 135 (42%) in conventional transplant and 34 (30%) in RIST (P=0.037). Number of patients who received fluconazole until engraftment and beyond day 75 in conventional transplant vs RIST was, respectively, 324 (100%) vs 109 (97%), and 39 (12%) vs 18 (16%), with no significant difference between the two groups. A total of 37 patients (4.0%) were diagnosed with deep fungal infections; autologous transplantation (0.03%), conventional transplantation (6.0%) and RIST (7.1%). Wide variations in antifungal prophylaxis practice according to the type of transplant and the institutions, and deep fungal infection remain significant problems in RIST. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/15094754/A_nationwide_survey_of_deep_fungal_infections_and_fungal_prophylaxis_after_hematopoietic_stem_cell_transplantation_in_Japan_ L2 - https://doi.org/10.1038/sj.bmt.1704526 DB - PRIME DP - Unbound Medicine ER -