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Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies.

Abstract

BACKGROUND

Epidemiologic studies have generally reported positive associations between alcohol consumption and risk for colorectal cancer. However, findings related to specific alcoholic beverages or different anatomic sites in the large bowel have been inconsistent.

OBJECTIVE

To examine the relationship of total alcohol intake and intake from specific beverages to the incidence of colorectal cancer and to evaluate whether other potential risk factors modify the association.

DESIGN

Pooled analysis of primary data from 8 cohort studies in 5 countries.

SETTING

North America and Europe.

PARTICIPANTS

489,979 women and men with no history of cancer other than nonmelanoma skin cancer at baseline.

MEASUREMENTS

Alcohol intake was assessed in each study at baseline by using a validated food-frequency questionnaire.

RESULTS

During a maximum of 6 to 16 years of follow-up across the studies, 4687 cases of colorectal cancer were documented. In categorical analyses, increased risk for colorectal cancer was limited to persons with an alcohol intake of 30 g/d or greater (approximately > or =2 drinks/d), a consumption level reported by 4% of women and 13% of men. Compared with nondrinkers, the pooled multivariate relative risks were 1.16 (95% CI, 0.99 to 1.36) for persons who consumed 30 to less than 45 g/d and 1.41 (CI, 1.16 to 1.72) for those who consumed 45 g/d or greater. No significant heterogeneity by study or sex was observed. The association was evident for cancer of the proximal colon, distal colon, and rectum. No clear difference in relative risks was found among specific alcoholic beverages.

LIMITATIONS

The study included only one measure of alcohol consumption at baseline and could not investigate lifetime alcohol consumption, alcohol consumption at younger ages, or changes in alcohol consumption during follow-up. It also could not examine drinking patterns or duration of alcohol use.

CONCLUSIONS

A single determination of alcohol intake correlated with a modest relative elevation in colorectal cancer rate, mainly at the highest levels of alcohol intake.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Harvard School of Public Health, and Harvard Center for Cancer Prevention, Boston, Massachusetts 02115, USA. eunyoung.cho@channing.harvard.edu

    , , , , , , , , , , , , , , , , , , ,

    Source

    Annals of internal medicine 140:8 2004 Apr 20 pg 603-13

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Alcoholic Beverages
    Alcoholism
    Colorectal Neoplasms
    Europe
    Female
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Multivariate Analysis
    North America
    Prospective Studies
    Risk Factors
    Sex Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15096331

    Citation

    Cho, Eunyoung, et al. "Alcohol Intake and Colorectal Cancer: a Pooled Analysis of 8 Cohort Studies." Annals of Internal Medicine, vol. 140, no. 8, 2004, pp. 603-13.
    Cho E, Smith-Warner SA, Ritz J, et al. Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies. Ann Intern Med. 2004;140(8):603-13.
    Cho, E., Smith-Warner, S. A., Ritz, J., van den Brandt, P. A., Colditz, G. A., Folsom, A. R., ... Hunter, D. J. (2004). Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies. Annals of Internal Medicine, 140(8), pp. 603-13.
    Cho E, et al. Alcohol Intake and Colorectal Cancer: a Pooled Analysis of 8 Cohort Studies. Ann Intern Med. 2004 Apr 20;140(8):603-13. PubMed PMID: 15096331.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies. AU - Cho,Eunyoung, AU - Smith-Warner,Stephanie A, AU - Ritz,John, AU - van den Brandt,Piet A, AU - Colditz,Graham A, AU - Folsom,Aaron R, AU - Freudenheim,Jo L, AU - Giovannucci,Edward, AU - Goldbohm,R Alexandra, AU - Graham,Saxon, AU - Holmberg,Lars, AU - Kim,Dong-Hyun, AU - Malila,Nea, AU - Miller,Anthony B, AU - Pietinen,Pirjo, AU - Rohan,Thomas E, AU - Sellers,Thomas A, AU - Speizer,Frank E, AU - Willett,Walter C, AU - Wolk,Alicja, AU - Hunter,David J, PY - 2004/4/21/pubmed PY - 2004/5/5/medline PY - 2004/4/21/entrez SP - 603 EP - 13 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 140 IS - 8 N2 - BACKGROUND: Epidemiologic studies have generally reported positive associations between alcohol consumption and risk for colorectal cancer. However, findings related to specific alcoholic beverages or different anatomic sites in the large bowel have been inconsistent. OBJECTIVE: To examine the relationship of total alcohol intake and intake from specific beverages to the incidence of colorectal cancer and to evaluate whether other potential risk factors modify the association. DESIGN: Pooled analysis of primary data from 8 cohort studies in 5 countries. SETTING: North America and Europe. PARTICIPANTS: 489,979 women and men with no history of cancer other than nonmelanoma skin cancer at baseline. MEASUREMENTS: Alcohol intake was assessed in each study at baseline by using a validated food-frequency questionnaire. RESULTS: During a maximum of 6 to 16 years of follow-up across the studies, 4687 cases of colorectal cancer were documented. In categorical analyses, increased risk for colorectal cancer was limited to persons with an alcohol intake of 30 g/d or greater (approximately > or =2 drinks/d), a consumption level reported by 4% of women and 13% of men. Compared with nondrinkers, the pooled multivariate relative risks were 1.16 (95% CI, 0.99 to 1.36) for persons who consumed 30 to less than 45 g/d and 1.41 (CI, 1.16 to 1.72) for those who consumed 45 g/d or greater. No significant heterogeneity by study or sex was observed. The association was evident for cancer of the proximal colon, distal colon, and rectum. No clear difference in relative risks was found among specific alcoholic beverages. LIMITATIONS: The study included only one measure of alcohol consumption at baseline and could not investigate lifetime alcohol consumption, alcohol consumption at younger ages, or changes in alcohol consumption during follow-up. It also could not examine drinking patterns or duration of alcohol use. CONCLUSIONS: A single determination of alcohol intake correlated with a modest relative elevation in colorectal cancer rate, mainly at the highest levels of alcohol intake. SN - 1539-3704 UR - https://www.unboundmedicine.com/medline/citation/15096331/Alcohol_intake_and_colorectal_cancer:_a_pooled_analysis_of_8_cohort_studies_ L2 - https://www.annals.org/article.aspx?volume=140&issue=8&page=603 DB - PRIME DP - Unbound Medicine ER -