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Brief presence of varicella-zoster vral DNA in mononuclear cells during relapses of multiple sclerosis.
Arch Neurol 2004; 61(4):529-32AN

Abstract

BACKGROUND

A possible viral cause for multiple sclerosis (MS) has long been suspected. A progressive increase in MS has been reported in Mexico during the past 20 years; a conspicuous antecedent of varicella infection during childhood has been the most relevant finding in the medical history of patients with MS.

OBJECTIVE

To investigate the possible participation of varicella-zoster virus (VZV) in the etiopathogenesis of MS.

DESIGN, SETTING, AND PATIENTS

We searched, by polymerase chain reaction (PCR), for VZV DNA in peripheral mononuclear cells of 82 patients with relapsing-remitting MS. Additionally, genes gD from herpes simplex viruses 1 and 2 were sought by PCR, as well as IgG and IgM serum antibodies to VZV.

RESULTS

Viral DNA from the genes open reading frame (ORF)31, ORF62, ORF63, and ORF67 of VZV was found in mononuclear cells from 13 (87%) of 15 patients with MS who were tested during acute relapse. All patients who were tested during remission (n = 67) were negative for the DNA, including patients who were initially positive and were tested again after 2 months of remission. All control patients with a comprehensive variety of neurologic diseases (n = 100) and healthy controls (n = 20) also tested negative. All subjects were negative for herpes simplex viruses 1 and 2 DNA, and no differences were found in serum antibodies to VZV.

CONCLUSIONS

The finding of genes of VZV in peripheral mononuclear cells, restricted to a brief period during clinical relapse of MS, suggests either its participation in the etiopathogenesis of MS or an epiphenomenon of viral activation simultaneous with the relapse of MS.

Authors+Show Affiliations

Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico City.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15096401

Citation

Ordoñez, Graciela, et al. "Brief Presence of Varicella-zoster Vral DNA in Mononuclear Cells During Relapses of Multiple Sclerosis." Archives of Neurology, vol. 61, no. 4, 2004, pp. 529-32.
Ordoñez G, Pineda B, Garcia-Navarrete R, et al. Brief presence of varicella-zoster vral DNA in mononuclear cells during relapses of multiple sclerosis. Arch Neurol. 2004;61(4):529-32.
Ordoñez, G., Pineda, B., Garcia-Navarrete, R., & Sotelo, J. (2004). Brief presence of varicella-zoster vral DNA in mononuclear cells during relapses of multiple sclerosis. Archives of Neurology, 61(4), pp. 529-32.
Ordoñez G, et al. Brief Presence of Varicella-zoster Vral DNA in Mononuclear Cells During Relapses of Multiple Sclerosis. Arch Neurol. 2004;61(4):529-32. PubMed PMID: 15096401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brief presence of varicella-zoster vral DNA in mononuclear cells during relapses of multiple sclerosis. AU - Ordoñez,Graciela, AU - Pineda,Benjamin, AU - Garcia-Navarrete,Roberto, AU - Sotelo,Julio, PY - 2004/4/21/pubmed PY - 2004/5/5/medline PY - 2004/4/21/entrez SP - 529 EP - 32 JF - Archives of neurology JO - Arch. Neurol. VL - 61 IS - 4 N2 - BACKGROUND: A possible viral cause for multiple sclerosis (MS) has long been suspected. A progressive increase in MS has been reported in Mexico during the past 20 years; a conspicuous antecedent of varicella infection during childhood has been the most relevant finding in the medical history of patients with MS. OBJECTIVE: To investigate the possible participation of varicella-zoster virus (VZV) in the etiopathogenesis of MS. DESIGN, SETTING, AND PATIENTS: We searched, by polymerase chain reaction (PCR), for VZV DNA in peripheral mononuclear cells of 82 patients with relapsing-remitting MS. Additionally, genes gD from herpes simplex viruses 1 and 2 were sought by PCR, as well as IgG and IgM serum antibodies to VZV. RESULTS: Viral DNA from the genes open reading frame (ORF)31, ORF62, ORF63, and ORF67 of VZV was found in mononuclear cells from 13 (87%) of 15 patients with MS who were tested during acute relapse. All patients who were tested during remission (n = 67) were negative for the DNA, including patients who were initially positive and were tested again after 2 months of remission. All control patients with a comprehensive variety of neurologic diseases (n = 100) and healthy controls (n = 20) also tested negative. All subjects were negative for herpes simplex viruses 1 and 2 DNA, and no differences were found in serum antibodies to VZV. CONCLUSIONS: The finding of genes of VZV in peripheral mononuclear cells, restricted to a brief period during clinical relapse of MS, suggests either its participation in the etiopathogenesis of MS or an epiphenomenon of viral activation simultaneous with the relapse of MS. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/15096401/Brief_presence_of_varicella_zoster_vral_DNA_in_mononuclear_cells_during_relapses_of_multiple_sclerosis_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.61.4.529 DB - PRIME DP - Unbound Medicine ER -