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Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum.
J Alzheimers Dis 2004; 6(2):159-63JA

Abstract

Although several studies show the importance of oxidative stress in the pathogenesis of Alzheimer's disease (AD), there are few evidences on the role of free radicals in Mild Cognitive Impairment (MCI). Our results showing a marked decrease of the main components of the antioxidant defense system of the organism support the hypothesis that in MCI there is a condition of oxidative stress. This work also gives an overview on the existing evidence of the early occurrence of oxidative processes in the development of dementing disorders of the Alzheimer type. Since MCI represents a condition of increased risk for AD, use of antioxidants in MCI could be of importance for prevention.

Authors+Show Affiliations

Sezione di Gerontologia e Geriatria, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Monteluce-Padiglione E, via Brunamonti, 51, 06122 Perugia, Italy. mecocci@unipg.it

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15096699

Citation

Mecocci, Patrizia. "Oxidative Stress in Mild Cognitive Impairment and Alzheimer Disease: a Continuum." Journal of Alzheimer's Disease : JAD, vol. 6, no. 2, 2004, pp. 159-63.
Mecocci P. Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. J Alzheimers Dis. 2004;6(2):159-63.
Mecocci, P. (2004). Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. Journal of Alzheimer's Disease : JAD, 6(2), pp. 159-63.
Mecocci P. Oxidative Stress in Mild Cognitive Impairment and Alzheimer Disease: a Continuum. J Alzheimers Dis. 2004;6(2):159-63. PubMed PMID: 15096699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. A1 - Mecocci,Patrizia, PY - 2004/4/21/pubmed PY - 2004/9/17/medline PY - 2004/4/21/entrez SP - 159 EP - 63 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 6 IS - 2 N2 - Although several studies show the importance of oxidative stress in the pathogenesis of Alzheimer's disease (AD), there are few evidences on the role of free radicals in Mild Cognitive Impairment (MCI). Our results showing a marked decrease of the main components of the antioxidant defense system of the organism support the hypothesis that in MCI there is a condition of oxidative stress. This work also gives an overview on the existing evidence of the early occurrence of oxidative processes in the development of dementing disorders of the Alzheimer type. Since MCI represents a condition of increased risk for AD, use of antioxidants in MCI could be of importance for prevention. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/15096699/Oxidative_stress_in_mild_cognitive_impairment_and_Alzheimer_disease:_a_continuum_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=6&issue=2&spage=159 DB - PRIME DP - Unbound Medicine ER -