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Cutaneous miliary tuberculosis in two patients with HIV infection.
J Am Acad Dermatol. 2004 May; 50(5 Suppl):S110-3.JA

Abstract

Cutaneous manifestations of miliary tuberculosis are rare. We report two patients with previously unknown advanced human immunodeficiency virus (HIV) infection, who presented with respiratory collapse and an erythematous papulopustular skin eruption. Skin biopsies demonstrated focal dermal microabscess in one patient, and a subcorneal vesicle with an underlying dermal microabscess in the other. Despite the lack of granulomatous inflammation, acid-fast bacilli (AFB) and Fite stains demonstrated numerous acid-fast bacilli, and Mycobacterium tuberculosis was subsequently isolated in either skin and/or sputum cultures. Pulmonary involvement was present in both cases, but was sufficiently diffuse and atypical so as not to be specific for tuberculosis upon initial clinical and radiographic examination. Our two cases illustrate the importance of careful skin examination in patients with HIV infection, since cutaneous dissemination can be an easily overlooked sign of miliary tuberculosis.

Authors+Show Affiliations

Department of Dermatology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9073, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

15097943

Citation

High, Whitney A., et al. "Cutaneous Miliary Tuberculosis in Two Patients With HIV Infection." Journal of the American Academy of Dermatology, vol. 50, no. 5 Suppl, 2004, pp. S110-3.
High WA, Evans CC, Hoang MP. Cutaneous miliary tuberculosis in two patients with HIV infection. J Am Acad Dermatol. 2004;50(5 Suppl):S110-3.
High, W. A., Evans, C. C., & Hoang, M. P. (2004). Cutaneous miliary tuberculosis in two patients with HIV infection. Journal of the American Academy of Dermatology, 50(5 Suppl), S110-3.
High WA, Evans CC, Hoang MP. Cutaneous Miliary Tuberculosis in Two Patients With HIV Infection. J Am Acad Dermatol. 2004;50(5 Suppl):S110-3. PubMed PMID: 15097943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous miliary tuberculosis in two patients with HIV infection. AU - High,Whitney A, AU - Evans,Colby C, AU - Hoang,Mai P, PY - 2004/4/21/pubmed PY - 2004/6/5/medline PY - 2004/4/21/entrez SP - S110 EP - 3 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 50 IS - 5 Suppl N2 - Cutaneous manifestations of miliary tuberculosis are rare. We report two patients with previously unknown advanced human immunodeficiency virus (HIV) infection, who presented with respiratory collapse and an erythematous papulopustular skin eruption. Skin biopsies demonstrated focal dermal microabscess in one patient, and a subcorneal vesicle with an underlying dermal microabscess in the other. Despite the lack of granulomatous inflammation, acid-fast bacilli (AFB) and Fite stains demonstrated numerous acid-fast bacilli, and Mycobacterium tuberculosis was subsequently isolated in either skin and/or sputum cultures. Pulmonary involvement was present in both cases, but was sufficiently diffuse and atypical so as not to be specific for tuberculosis upon initial clinical and radiographic examination. Our two cases illustrate the importance of careful skin examination in patients with HIV infection, since cutaneous dissemination can be an easily overlooked sign of miliary tuberculosis. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/15097943/Cutaneous_miliary_tuberculosis_in_two_patients_with_HIV_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S019096220304297X DB - PRIME DP - Unbound Medicine ER -