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Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down.
Eur J Appl Physiol. 2004 Jul; 92(3):328-33.EJ

Abstract

The purpose of this study was to determine the effect of a post-exercise active cool-down on von Willebrand factor and fibrinolysis. Ten subjects performed two maximal oxygen uptake (VO2max) tests followed by a 10-min passive (PC) or an active (AC) cool-down. Blood samples were obtained pre-exercise, post-exercise, post-PC/AC, and 1 h post-exercise and analyzed for von Willebrand factor antigen (vWf:Ag), tissue plasminogen activator (tPA) antigen and activity and plasminogen activator inhibitor-1 (PAI-1) activity. Data were analyzed using repeated measures analysis of variance. No significant differences were found between VO2max tests for treadmill time, VO2max, respiratory exchange ratio, maximal heart rate, or maximal blood lactate concentration. vWf:Ag was significantly elevated (P <0.05)following PC [198.4 (18.3)% normal] versus AC [174.5 (15.6)% normal] and remained elevated 1-h post-exercise [179.4 (16.4)% normal for PC vs 158.6 (13.8)% normal for AC]. There were no differences between tests for tPA or PAI-1 activity, although tPA antigen was significantly elevated following PC versus AC (P <0.05). Following the cool-down, hematocrit was higher (P <0.05) for the PC test [48.90 (0.36)] compared with AC [47.43 (0.51)]. An AC reduces post-exercise vWf:Ag and tPA antigen without affecting tPA or PAI-1 activity.

Authors+Show Affiliations

Human Energy Research Laboratory, Department of Kinesiology, Michigan State University, East Lansing, MI 48824, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15098129

Citation

Paton, C M., et al. "Changes in Von Willebrand Factor and Fibrinolysis Following a Post-exercise Cool-down." European Journal of Applied Physiology, vol. 92, no. 3, 2004, pp. 328-33.
Paton CM, Nagelkirk PR, Coughlin AM, et al. Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down. Eur J Appl Physiol. 2004;92(3):328-33.
Paton, C. M., Nagelkirk, P. R., Coughlin, A. M., Cooper, J. A., Davis, G. A., Hassouna, H., Pivarnik, J. M., & Womack, C. J. (2004). Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down. European Journal of Applied Physiology, 92(3), 328-33.
Paton CM, et al. Changes in Von Willebrand Factor and Fibrinolysis Following a Post-exercise Cool-down. Eur J Appl Physiol. 2004;92(3):328-33. PubMed PMID: 15098129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down. AU - Paton,C M, AU - Nagelkirk,P R, AU - Coughlin,A M, AU - Cooper,J A, AU - Davis,G A, AU - Hassouna,H, AU - Pivarnik,J M, AU - Womack,C J, Y1 - 2004/04/20/ PY - 2004/03/04/accepted PY - 2004/4/21/pubmed PY - 2005/1/26/medline PY - 2004/4/21/entrez SP - 328 EP - 33 JF - European journal of applied physiology JO - Eur J Appl Physiol VL - 92 IS - 3 N2 - The purpose of this study was to determine the effect of a post-exercise active cool-down on von Willebrand factor and fibrinolysis. Ten subjects performed two maximal oxygen uptake (VO2max) tests followed by a 10-min passive (PC) or an active (AC) cool-down. Blood samples were obtained pre-exercise, post-exercise, post-PC/AC, and 1 h post-exercise and analyzed for von Willebrand factor antigen (vWf:Ag), tissue plasminogen activator (tPA) antigen and activity and plasminogen activator inhibitor-1 (PAI-1) activity. Data were analyzed using repeated measures analysis of variance. No significant differences were found between VO2max tests for treadmill time, VO2max, respiratory exchange ratio, maximal heart rate, or maximal blood lactate concentration. vWf:Ag was significantly elevated (P <0.05)following PC [198.4 (18.3)% normal] versus AC [174.5 (15.6)% normal] and remained elevated 1-h post-exercise [179.4 (16.4)% normal for PC vs 158.6 (13.8)% normal for AC]. There were no differences between tests for tPA or PAI-1 activity, although tPA antigen was significantly elevated following PC versus AC (P <0.05). Following the cool-down, hematocrit was higher (P <0.05) for the PC test [48.90 (0.36)] compared with AC [47.43 (0.51)]. An AC reduces post-exercise vWf:Ag and tPA antigen without affecting tPA or PAI-1 activity. SN - 1439-6319 UR - https://www.unboundmedicine.com/medline/citation/15098129/Changes_in_von_Willebrand_factor_and_fibrinolysis_following_a_post_exercise_cool_down_ L2 - https://dx.doi.org/10.1007/s00421-004-1098-1 DB - PRIME DP - Unbound Medicine ER -