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Left ventricular mass and function in children with GH deficiency before and during 12 months GH replacement therapy.
Clin Endocrinol (Oxf). 2004 May; 60(5):630-6.CE

Abstract

OBJECTIVE

This open, prospective study was designed to evaluate the effect of GH deficiency (GHD) on left ventricular (LV) mass (LVM) and performance, by echocardiography, and on lipid profile during childhood.

SUBJECTS

Twelve prepubertal children with GHD (eight boys and four girls) aged 8.1 +/- 1.7 years were studied before and after 6 and 12 months of GH replacement therapy at a dose of GH of 30 micro g/kg/day. Twelve healthy children sex-, height-, weight- and body surface area-matched with the patients, served as controls.

METHODS

Echocardiography was performed at study entry and after 12 months both in GHD children and in controls. Only in GHD children, echocardiography was repeated also after 6 months of GH replacement. In all subjects, we measured LV posterior wall thickness (LVPWT), LV end-diastolic diameter (LVEDD), LVM index (LVMi), LV systolic and diastolic function.

RESULTS

At study entry, LVPWT (5.3 +/- 0.8 vs. 6.2 +/- 1.1 mm, P < 0.05), LVEDD (34.0 +/- 2.4 vs. 36.7 +/- 2.1 mm, P < 0.007) and LVMi (47.0 +/- 6.9 vs. 59.6 +/- 9.5 g/m2, P < 0.005) were significantly lower in GHD children than in controls. Lipid profile, heart rate, blood pressure, LV systolic function and indices of ventricular filling were similar in patients and controls. After 12 months of GH replacement therapy, LVPWT (6.1 +/- 0.7 mm, P < 0.0005), LVEDD (38.8 +/- 4.3 mm, P < 0.002) and LVMi (71.5 +/- 12.7 g/m2, P < 0.0005) significantly increased in GHD children compared to pretreatment values. In particular, after 12 months of therapy GHD children achieved a normal LVMi when compared to controls (60.7 +/- 8.6, P = ns). LVMi increase was significantly correlated with the increase in IGF-I level (r = 0.49; P < 0.004). LV systolic performance, diastolic filling and blood pressure did not change significantly during GH therapy. After 12 months of treatment, the atherogenic index, measured as total/high-density lipoprotein-cholesterol ratio (2.7 +/- 0.8) was significantly lower than both pretreatment (3.4 +/- 0.3, P < 0.03) and control values (3.8 +/- 1.1, P < 0.04).

CONCLUSIONS

GH deficiency in children affects heart morphology, by inducing a significant decrease in cardiac size, but does not modify cardiac function and lipid profile. Twelve months of GH replacement treatment normalizes cardiac mass, and reduces the atherogenic index.

Authors+Show Affiliations

Department of Pediatrics, University Frederico II of Naples, Naples, Italy. salerno@unina.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15104568

Citation

Salerno, Mariacarolina, et al. "Left Ventricular Mass and Function in Children With GH Deficiency Before and During 12 Months GH Replacement Therapy." Clinical Endocrinology, vol. 60, no. 5, 2004, pp. 630-6.
Salerno M, Esposito V, Spinelli L, et al. Left ventricular mass and function in children with GH deficiency before and during 12 months GH replacement therapy. Clin Endocrinol (Oxf). 2004;60(5):630-6.
Salerno, M., Esposito, V., Spinelli, L., Di Somma, C., Farina, V., Muzzica, S., de Horatio, L. T., Lombardi, G., & Colao, A. (2004). Left ventricular mass and function in children with GH deficiency before and during 12 months GH replacement therapy. Clinical Endocrinology, 60(5), 630-6.
Salerno M, et al. Left Ventricular Mass and Function in Children With GH Deficiency Before and During 12 Months GH Replacement Therapy. Clin Endocrinol (Oxf). 2004;60(5):630-6. PubMed PMID: 15104568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Left ventricular mass and function in children with GH deficiency before and during 12 months GH replacement therapy. AU - Salerno,Mariacarolina, AU - Esposito,Valentina, AU - Spinelli,Letizia, AU - Di Somma,Carolina, AU - Farina,Vincenzo, AU - Muzzica,Stefania, AU - de Horatio,Laura Tanturri, AU - Lombardi,Gaetano, AU - Colao,Annamaria, PY - 2004/4/24/pubmed PY - 2004/7/28/medline PY - 2004/4/24/entrez SP - 630 EP - 6 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 60 IS - 5 N2 - OBJECTIVE: This open, prospective study was designed to evaluate the effect of GH deficiency (GHD) on left ventricular (LV) mass (LVM) and performance, by echocardiography, and on lipid profile during childhood. SUBJECTS: Twelve prepubertal children with GHD (eight boys and four girls) aged 8.1 +/- 1.7 years were studied before and after 6 and 12 months of GH replacement therapy at a dose of GH of 30 micro g/kg/day. Twelve healthy children sex-, height-, weight- and body surface area-matched with the patients, served as controls. METHODS: Echocardiography was performed at study entry and after 12 months both in GHD children and in controls. Only in GHD children, echocardiography was repeated also after 6 months of GH replacement. In all subjects, we measured LV posterior wall thickness (LVPWT), LV end-diastolic diameter (LVEDD), LVM index (LVMi), LV systolic and diastolic function. RESULTS: At study entry, LVPWT (5.3 +/- 0.8 vs. 6.2 +/- 1.1 mm, P < 0.05), LVEDD (34.0 +/- 2.4 vs. 36.7 +/- 2.1 mm, P < 0.007) and LVMi (47.0 +/- 6.9 vs. 59.6 +/- 9.5 g/m2, P < 0.005) were significantly lower in GHD children than in controls. Lipid profile, heart rate, blood pressure, LV systolic function and indices of ventricular filling were similar in patients and controls. After 12 months of GH replacement therapy, LVPWT (6.1 +/- 0.7 mm, P < 0.0005), LVEDD (38.8 +/- 4.3 mm, P < 0.002) and LVMi (71.5 +/- 12.7 g/m2, P < 0.0005) significantly increased in GHD children compared to pretreatment values. In particular, after 12 months of therapy GHD children achieved a normal LVMi when compared to controls (60.7 +/- 8.6, P = ns). LVMi increase was significantly correlated with the increase in IGF-I level (r = 0.49; P < 0.004). LV systolic performance, diastolic filling and blood pressure did not change significantly during GH therapy. After 12 months of treatment, the atherogenic index, measured as total/high-density lipoprotein-cholesterol ratio (2.7 +/- 0.8) was significantly lower than both pretreatment (3.4 +/- 0.3, P < 0.03) and control values (3.8 +/- 1.1, P < 0.04). CONCLUSIONS: GH deficiency in children affects heart morphology, by inducing a significant decrease in cardiac size, but does not modify cardiac function and lipid profile. Twelve months of GH replacement treatment normalizes cardiac mass, and reduces the atherogenic index. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15104568/Left_ventricular_mass_and_function_in_children_with_GH_deficiency_before_and_during_12_months_GH_replacement_therapy_ DB - PRIME DP - Unbound Medicine ER -