Tags

Type your tag names separated by a space and hit enter

Gene dose mapping delineated boundaries of a large germline deletion responsible for multiple endocrine neoplasia type 1.
Cancer Lett. 2004 May 10; 208(1):81-8.CL

Abstract

A deleted genomic region including the MEN1 gene was determined in a family with multiple endocrine neoplasia type 1 caused by a large germline deletion. Gene dose mapping by the modified gene dose assay technique roughly located the deletion end points, which were then precisely determined by nucleotide sequencing. The deletion was approximately 68kbp flanked by a 3-base pair repeat and included the whole MEN1, MAP4K2 and KAPPA-200 genes. This is the first case of a large germline deletion responsible for multiple endocrine neoplasia type 1, in which the size and end points were determined precisely.

Authors+Show Affiliations

Tumor Endocrinology Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15105049

Citation

Kikuchi, Mariko, et al. "Gene Dose Mapping Delineated Boundaries of a Large Germline Deletion Responsible for Multiple Endocrine Neoplasia Type 1." Cancer Letters, vol. 208, no. 1, 2004, pp. 81-8.
Kikuchi M, Ohkura N, Yamaguchi K, et al. Gene dose mapping delineated boundaries of a large germline deletion responsible for multiple endocrine neoplasia type 1. Cancer Lett. 2004;208(1):81-8.
Kikuchi, M., Ohkura, N., Yamaguchi, K., Obara, T., & Tsukada, T. (2004). Gene dose mapping delineated boundaries of a large germline deletion responsible for multiple endocrine neoplasia type 1. Cancer Letters, 208(1), 81-8.
Kikuchi M, et al. Gene Dose Mapping Delineated Boundaries of a Large Germline Deletion Responsible for Multiple Endocrine Neoplasia Type 1. Cancer Lett. 2004 May 10;208(1):81-8. PubMed PMID: 15105049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene dose mapping delineated boundaries of a large germline deletion responsible for multiple endocrine neoplasia type 1. AU - Kikuchi,Mariko, AU - Ohkura,Naganari, AU - Yamaguchi,Ken, AU - Obara,Takao, AU - Tsukada,Toshihiko, PY - 2003/10/07/received PY - 2003/10/07/accepted PY - 2004/4/24/pubmed PY - 2004/6/29/medline PY - 2004/4/24/entrez SP - 81 EP - 8 JF - Cancer letters JO - Cancer Lett VL - 208 IS - 1 N2 - A deleted genomic region including the MEN1 gene was determined in a family with multiple endocrine neoplasia type 1 caused by a large germline deletion. Gene dose mapping by the modified gene dose assay technique roughly located the deletion end points, which were then precisely determined by nucleotide sequencing. The deletion was approximately 68kbp flanked by a 3-base pair repeat and included the whole MEN1, MAP4K2 and KAPPA-200 genes. This is the first case of a large germline deletion responsible for multiple endocrine neoplasia type 1, in which the size and end points were determined precisely. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/15105049/Gene_dose_mapping_delineated_boundaries_of_a_large_germline_deletion_responsible_for_multiple_endocrine_neoplasia_type_1_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304383503007092 DB - PRIME DP - Unbound Medicine ER -