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Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study.
Hum Reprod. 2004 Jun; 19(6):1461-4.HR

Abstract

BACKGROUND

A prospective, randomized, controlled study was performed to assess the efficacy of auto-crosslinked hyaluronic acid (ACP) gel to prevent the development of de-novo intrauterine adhesions following hysteroscopic surgery.

METHODS

One hundred and thirty-two patients with a single surgically remediable intrauterine lesion (myomas, polyps and uterine septa, subgroups I-III) completed the study. Patients were randomized to two different groups: group A underwent hysteroscopic surgery plus intrauterine application of ACP gel (10 ml) while group B underwent hysteroscopic surgery alone (control group). The rate of adhesion formation and the adhesion score was calculated for each group and subgroup 3 months after surgery.

RESULTS

Group A showed a significant reduction in the development of de-novo intrauterine adhesions at 3 months follow-up in comparison with the control group. Furthermore, the staging of adhesions showed a significant decrease in adhesion severity in patients treated with ACP gel.

CONCLUSIONS

ACP gel significantly reduces the incidence and severity of de-novo formation of intrauterine adhesions after hysteroscopic surgery.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15105384

Citation

Guida, Maurizio, et al. "Effectiveness of Auto-crosslinked Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Hysteroscopic Surgery: a Prospective, Randomized, Controlled Study." Human Reproduction (Oxford, England), vol. 19, no. 6, 2004, pp. 1461-4.
Guida M, Acunzo G, Di Spiezio Sardo A, et al. Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. Hum Reprod. 2004;19(6):1461-4.
Guida, M., Acunzo, G., Di Spiezio Sardo, A., Bifulco, G., Piccoli, R., Pellicano, M., Cerrota, G., Cirillo, D., & Nappi, C. (2004). Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. Human Reproduction (Oxford, England), 19(6), 1461-4.
Guida M, et al. Effectiveness of Auto-crosslinked Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Hysteroscopic Surgery: a Prospective, Randomized, Controlled Study. Hum Reprod. 2004;19(6):1461-4. PubMed PMID: 15105384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. AU - Guida,Maurizio, AU - Acunzo,Giuseppe, AU - Di Spiezio Sardo,Attilio, AU - Bifulco,Giuseppe, AU - Piccoli,Roberto, AU - Pellicano,Massimiliano, AU - Cerrota,Giuseppe, AU - Cirillo,Domenico, AU - Nappi,Carmine, Y1 - 2004/04/22/ PY - 2004/4/24/pubmed PY - 2004/12/22/medline PY - 2004/4/24/entrez SP - 1461 EP - 4 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 19 IS - 6 N2 - BACKGROUND: A prospective, randomized, controlled study was performed to assess the efficacy of auto-crosslinked hyaluronic acid (ACP) gel to prevent the development of de-novo intrauterine adhesions following hysteroscopic surgery. METHODS: One hundred and thirty-two patients with a single surgically remediable intrauterine lesion (myomas, polyps and uterine septa, subgroups I-III) completed the study. Patients were randomized to two different groups: group A underwent hysteroscopic surgery plus intrauterine application of ACP gel (10 ml) while group B underwent hysteroscopic surgery alone (control group). The rate of adhesion formation and the adhesion score was calculated for each group and subgroup 3 months after surgery. RESULTS: Group A showed a significant reduction in the development of de-novo intrauterine adhesions at 3 months follow-up in comparison with the control group. Furthermore, the staging of adhesions showed a significant decrease in adhesion severity in patients treated with ACP gel. CONCLUSIONS: ACP gel significantly reduces the incidence and severity of de-novo formation of intrauterine adhesions after hysteroscopic surgery. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/15105384/Effectiveness_of_auto_crosslinked_hyaluronic_acid_gel_in_the_prevention_of_intrauterine_adhesions_after_hysteroscopic_surgery:_a_prospective_randomized_controlled_study_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deh238 DB - PRIME DP - Unbound Medicine ER -