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Inositol for depressive disorders.
Cochrane Database Syst Rev 2004; (2):CD004049CD

Abstract

BACKGROUND

There are a number of effective interventions for the treatment of depression. It is possible that the efficacy of these treatments will be improved further by the use of adjunctive therapies such as inositol.

OBJECTIVES

1. To determine the effectiveness of inositol in the treatment of depression.2. To determine the adverse effects and acceptability of treatment with inositol.

SEARCH STRATEGY

The Cochrane Controlled Trials Register (CCTR), The Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register (CCDANCTR) incorporating results of group searches of EMBASE, MEDLINE, LILACS, CINAHL, PSYNDEX and PsycLIT were searched. Reference lists of relevant papers and major textbooks of affective disorder were checked. Experts in the field and pharmaceutical companies were contacted regarding unpublished material.

SELECTION CRITERIA

All randomised controlled trials that compare treatment with inositol, whether as monotherapy or adjunctive therapy, to an alternative treatment, whether another antidepressant medication or placebo, for patients with a diagnosis of depressive disorder (diagnosed according to explicit criteria).

DATA COLLECTION AND ANALYSIS

Data were independently extracted from the original reports by two reviewers. Statistical analysis was conducted using Review Manager version 4.2.1.

MAIN RESULTS

Four trials were identified, with a total of 141 participants. These were short term trials of double-blind design. The trials did not show clear evidence of a therapeutic benefit, nor any evidence of poor acceptability.

REVIEWERS' CONCLUSIONS

It is currently unclear whether or not inositol is of benefit in the treatment of depression. Ongoing studies should reduce this uncertainty.

Authors+Show Affiliations

Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, Oxfordshire, UK, OX3 7JK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

15106232

Citation

Taylor, M J., et al. "Inositol for Depressive Disorders." The Cochrane Database of Systematic Reviews, 2004, p. CD004049.
Taylor MJ, Wilder H, Bhagwagar Z, et al. Inositol for depressive disorders. Cochrane Database Syst Rev. 2004.
Taylor, M. J., Wilder, H., Bhagwagar, Z., & Geddes, J. (2004). Inositol for depressive disorders. The Cochrane Database of Systematic Reviews, (2), p. CD004049.
Taylor MJ, et al. Inositol for Depressive Disorders. Cochrane Database Syst Rev. 2004;(2)CD004049. PubMed PMID: 15106232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inositol for depressive disorders. AU - Taylor,M J, AU - Wilder,H, AU - Bhagwagar,Z, AU - Geddes,J, PY - 2004/4/24/pubmed PY - 2004/8/18/medline PY - 2004/4/24/entrez SP - CD004049 EP - CD004049 JF - The Cochrane database of systematic reviews JO - Cochrane Database Syst Rev IS - 2 N2 - BACKGROUND: There are a number of effective interventions for the treatment of depression. It is possible that the efficacy of these treatments will be improved further by the use of adjunctive therapies such as inositol. OBJECTIVES: 1. To determine the effectiveness of inositol in the treatment of depression.2. To determine the adverse effects and acceptability of treatment with inositol. SEARCH STRATEGY: The Cochrane Controlled Trials Register (CCTR), The Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register (CCDANCTR) incorporating results of group searches of EMBASE, MEDLINE, LILACS, CINAHL, PSYNDEX and PsycLIT were searched. Reference lists of relevant papers and major textbooks of affective disorder were checked. Experts in the field and pharmaceutical companies were contacted regarding unpublished material. SELECTION CRITERIA: All randomised controlled trials that compare treatment with inositol, whether as monotherapy or adjunctive therapy, to an alternative treatment, whether another antidepressant medication or placebo, for patients with a diagnosis of depressive disorder (diagnosed according to explicit criteria). DATA COLLECTION AND ANALYSIS: Data were independently extracted from the original reports by two reviewers. Statistical analysis was conducted using Review Manager version 4.2.1. MAIN RESULTS: Four trials were identified, with a total of 141 participants. These were short term trials of double-blind design. The trials did not show clear evidence of a therapeutic benefit, nor any evidence of poor acceptability. REVIEWERS' CONCLUSIONS: It is currently unclear whether or not inositol is of benefit in the treatment of depression. Ongoing studies should reduce this uncertainty. SN - 1469-493X UR - https://www.unboundmedicine.com/medline/citation/15106232/Inositol_for_depressive_disorders_ L2 - https://doi.org/10.1002/14651858.CD004049.pub2 DB - PRIME DP - Unbound Medicine ER -