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Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11.
Am J Med Genet B Neuropsychiatr Genet. 2004 May 15; 127B(1):30-4.AJ

Abstract

As part of an extensive study in the Portuguese Island population of families with multiple patients suffering from bipolar disorder and schizophrenia, we performed an initial genome-wide scan of 16 extended families with bipolar disorder that identified three regions on chromosomes 2, 11, and 19 with genome-wide suggestive linkage and several other regions, including chromosome 6q, also approached suggestive levels of significance. Dick et al. [2003: Am J Hum Genet 73:107-114] recently reported in a study of 250 families with bipolar disorder a maxLOD score of 3.61 near marker D6S1021 on chromosome 6q. This study replicates this finding having detected a peak NPL = 2.02 (P = 0.025) with the same marker D6S1021(104.7 Mb). Higher-density mapping provided additional support for loci on chromosome 6 including marker D6S1021 with an NPL = 2.59 (P = 0.0068) and peaking at marker D6S1639 (125 Mb) with an NPL = 3.06 (P = 0.0019). A similar pattern was detected with higher-density mapping of chromosome 11 with an NPL = 3.15 (P = 0.0014) at marker D11S1883 (63.1 Mb). Simulations at the density of our fine mapping data indicate that less than 1 scan out of 10 would find two such scores genome-wide in the same scan by chance. Our findings provide additional support for a susceptibility locus for bipolar disorder on 6q, as well as, suggesting the importance of denser scans. Published 2004 Wiley-Liss, Inc.

Authors+Show Affiliations

Veterans Affairs Medical Center, Washington, DC 20422, USA. cmpato@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15108176

Citation

Pato, Carlos N., et al. "Genome-wide Scan in Portuguese Island Families Implicates Multiple Loci in Bipolar Disorder: Fine Mapping Adds Support On Chromosomes 6 and 11." American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, vol. 127B, no. 1, 2004, pp. 30-4.
Pato CN, Pato MT, Kirby A, et al. Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11. Am J Med Genet B Neuropsychiatr Genet. 2004;127B(1):30-4.
Pato, C. N., Pato, M. T., Kirby, A., Petryshen, T. L., Medeiros, H., Carvalho, C., Macedo, A., Dourado, A., Coelho, I., Valente, J., Soares, M. J., Ferreira, C. P., Lei, M., Verner, A., Hudson, T. J., Morley, C. P., Kennedy, J. L., Azevedo, M. H., Daly, M. J., & Sklar, P. (2004). Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 127B(1), 30-4.
Pato CN, et al. Genome-wide Scan in Portuguese Island Families Implicates Multiple Loci in Bipolar Disorder: Fine Mapping Adds Support On Chromosomes 6 and 11. Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):30-4. PubMed PMID: 15108176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11. AU - Pato,Carlos N, AU - Pato,M T, AU - Kirby,A, AU - Petryshen,T L, AU - Medeiros,H, AU - Carvalho,C, AU - Macedo,A, AU - Dourado,A, AU - Coelho,I, AU - Valente,J, AU - Soares,M J, AU - Ferreira,C P, AU - Lei,M, AU - Verner,A, AU - Hudson,T J, AU - Morley,C P, AU - Kennedy,J L, AU - Azevedo,M H, AU - Daly,M J, AU - Sklar,P, PY - 2004/4/27/pubmed PY - 2004/11/4/medline PY - 2004/4/27/entrez SP - 30 EP - 4 JF - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics JO - Am. J. Med. Genet. B Neuropsychiatr. Genet. VL - 127B IS - 1 N2 - As part of an extensive study in the Portuguese Island population of families with multiple patients suffering from bipolar disorder and schizophrenia, we performed an initial genome-wide scan of 16 extended families with bipolar disorder that identified three regions on chromosomes 2, 11, and 19 with genome-wide suggestive linkage and several other regions, including chromosome 6q, also approached suggestive levels of significance. Dick et al. [2003: Am J Hum Genet 73:107-114] recently reported in a study of 250 families with bipolar disorder a maxLOD score of 3.61 near marker D6S1021 on chromosome 6q. This study replicates this finding having detected a peak NPL = 2.02 (P = 0.025) with the same marker D6S1021(104.7 Mb). Higher-density mapping provided additional support for loci on chromosome 6 including marker D6S1021 with an NPL = 2.59 (P = 0.0068) and peaking at marker D6S1639 (125 Mb) with an NPL = 3.06 (P = 0.0019). A similar pattern was detected with higher-density mapping of chromosome 11 with an NPL = 3.15 (P = 0.0014) at marker D11S1883 (63.1 Mb). Simulations at the density of our fine mapping data indicate that less than 1 scan out of 10 would find two such scores genome-wide in the same scan by chance. Our findings provide additional support for a susceptibility locus for bipolar disorder on 6q, as well as, suggesting the importance of denser scans. Published 2004 Wiley-Liss, Inc. SN - 1552-4841 UR - https://www.unboundmedicine.com/medline/citation/15108176/Genome_wide_scan_in_Portuguese_Island_families_implicates_multiple_loci_in_bipolar_disorder:_fine_mapping_adds_support_on_chromosomes_6_and_11_ L2 - https://doi.org/10.1002/ajmg.b.30001 DB - PRIME DP - Unbound Medicine ER -