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Alpha-synuclein, Parkinson's disease, and Alzheimer's disease.
Parkinsonism Relat Disord. 2004 May; 10 Suppl 1:S9-13.PR

Abstract

Alpha synuclein (alpha-SN) is a ubiquitous protein that is especially abundant in the brain and has been postulated to play a central role in the pathogenesis of Parkinson's disease (PD), Alzheimer's disease, and other neurodegenerative disorders. Here, we show that alpha-SN plays dual role of neuroprotection and neurotoxicity depending on its concentration or level of expression. In addition, our study shows that alpha-synuclein is differentially expressed in human peripheral blood mononuclear cells. PD patients expressed more alpha-synuclein than healthy controls. Thus, the alpha-synuclein expression in the peripheral immune system might be one of the primary causes of immune abnormalities in PD patients.

Authors+Show Affiliations

Kim S
Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, National Creative Research Initiative Center for Alzheimer's Dementia, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-799, South Korea.
Seo JH
No affiliation info available
Suh YH
No affiliation info available

MeSH

Alzheimer DiseaseAnimalsHumansNerve Tissue ProteinsParkinson DiseaseSynucleinsalpha-Synuclein

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15109581

Citation

Kim, Seonghan, et al. "Alpha-synuclein, Parkinson's Disease, and Alzheimer's Disease." Parkinsonism & Related Disorders, vol. 10 Suppl 1, 2004, pp. S9-13.
Kim S, Seo JH, Suh YH. Alpha-synuclein, Parkinson's disease, and Alzheimer's disease. Parkinsonism Relat Disord. 2004;10 Suppl 1:S9-13.
Kim, S., Seo, J. H., & Suh, Y. H. (2004). Alpha-synuclein, Parkinson's disease, and Alzheimer's disease. Parkinsonism & Related Disorders, 10 Suppl 1, S9-13.
Kim S, Seo JH, Suh YH. Alpha-synuclein, Parkinson's Disease, and Alzheimer's Disease. Parkinsonism Relat Disord. 2004;10 Suppl 1:S9-13. PubMed PMID: 15109581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha-synuclein, Parkinson's disease, and Alzheimer's disease. AU - Kim,Seonghan, AU - Seo,Ji-Heui, AU - Suh,Yoo-Hun, PY - 2003/11/30/received PY - 2003/11/30/accepted PY - 2004/4/28/pubmed PY - 2004/6/30/medline PY - 2004/4/28/entrez SP - S9 EP - 13 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 10 Suppl 1 N2 - Alpha synuclein (alpha-SN) is a ubiquitous protein that is especially abundant in the brain and has been postulated to play a central role in the pathogenesis of Parkinson's disease (PD), Alzheimer's disease, and other neurodegenerative disorders. Here, we show that alpha-SN plays dual role of neuroprotection and neurotoxicity depending on its concentration or level of expression. In addition, our study shows that alpha-synuclein is differentially expressed in human peripheral blood mononuclear cells. PD patients expressed more alpha-synuclein than healthy controls. Thus, the alpha-synuclein expression in the peripheral immune system might be one of the primary causes of immune abnormalities in PD patients. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/15109581/Alpha_synuclein_Parkinson's_disease_and_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -