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Simulated post-exposure rabies vaccination with purified chick embryo cell vaccine using a modified Thai Red Cross regimen.
Int J Infect Dis. 2004 May; 8(3):175-9.IJ

Abstract

OBJECTIVES

Currently, two intradermal regimens for the administration of cell culture rabies vaccines are approved by the WHO for rabies post-exposure prophylaxis: the two site Thai Red Cross regimen (TRC) and the eight site regimen. For the TRC regimen the volume of vaccine recommended per dose is 0.1 ml of purified Vero cell rabies vaccine (PVRV) and 0.2 ml of purified chick embryo cell vaccine (PCEC). The objective of the present study was to evaluate comparatively the immune response to PCEC and PVRV vaccines administered by the TRC regimen using a uniform dose of 0.1 ml of vaccine.

METHODS

Forty-two subjects received TRC regimen (2-2-2-0-1-1) with 0.1 ml of PCEC vaccine and 38 subjects received the same regimen with PVRV. The rabies neutralizing antibody response in these subjects on days 10, 28, 90 and 180 was determined by the standard mouse neutralization test (MNT).

RESULTS

There was adequate antibody response with both the vaccines and 100% seroconversion was observed by day 10. Furthermore, the antibody titers obtained with PCEC did not differ significantly from those obtained with PVRV on all days tested (p > 0.05).

CONCLUSIONS

It can be concluded from the results that an adequate antibody response can be obtained with PCEC vaccine when administered by the TRC regimen even after reducing the quantity of vaccine from 0.2 ml to 0.1 ml per intradermal dose. The feasibility of using this regimen in true post-exposure cases needs to be further evaluated.

Authors+Show Affiliations

Department of Neurovirology, National Institute of Mental Health & Neurosciences, PN No. 2900, Hosur Road, Bangalore 560029, India. m.shampur@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

15109593

Citation

Madhusudana, S N., et al. "Simulated Post-exposure Rabies Vaccination With Purified Chick Embryo Cell Vaccine Using a Modified Thai Red Cross Regimen." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 8, no. 3, 2004, pp. 175-9.
Madhusudana SN, Sanjay TV, Mahendra BJ, et al. Simulated post-exposure rabies vaccination with purified chick embryo cell vaccine using a modified Thai Red Cross regimen. Int J Infect Dis. 2004;8(3):175-9.
Madhusudana, S. N., Sanjay, T. V., Mahendra, B. J., & Suja, M. S. (2004). Simulated post-exposure rabies vaccination with purified chick embryo cell vaccine using a modified Thai Red Cross regimen. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 8(3), 175-9.
Madhusudana SN, et al. Simulated Post-exposure Rabies Vaccination With Purified Chick Embryo Cell Vaccine Using a Modified Thai Red Cross Regimen. Int J Infect Dis. 2004;8(3):175-9. PubMed PMID: 15109593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simulated post-exposure rabies vaccination with purified chick embryo cell vaccine using a modified Thai Red Cross regimen. AU - Madhusudana,S N, AU - Sanjay,T V, AU - Mahendra,B J, AU - Suja,M S, PY - 2003/04/01/received PY - 2003/07/28/revised PY - 2003/07/30/accepted PY - 2004/4/28/pubmed PY - 2004/8/13/medline PY - 2004/4/28/entrez SP - 175 EP - 9 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 8 IS - 3 N2 - OBJECTIVES: Currently, two intradermal regimens for the administration of cell culture rabies vaccines are approved by the WHO for rabies post-exposure prophylaxis: the two site Thai Red Cross regimen (TRC) and the eight site regimen. For the TRC regimen the volume of vaccine recommended per dose is 0.1 ml of purified Vero cell rabies vaccine (PVRV) and 0.2 ml of purified chick embryo cell vaccine (PCEC). The objective of the present study was to evaluate comparatively the immune response to PCEC and PVRV vaccines administered by the TRC regimen using a uniform dose of 0.1 ml of vaccine. METHODS: Forty-two subjects received TRC regimen (2-2-2-0-1-1) with 0.1 ml of PCEC vaccine and 38 subjects received the same regimen with PVRV. The rabies neutralizing antibody response in these subjects on days 10, 28, 90 and 180 was determined by the standard mouse neutralization test (MNT). RESULTS: There was adequate antibody response with both the vaccines and 100% seroconversion was observed by day 10. Furthermore, the antibody titers obtained with PCEC did not differ significantly from those obtained with PVRV on all days tested (p > 0.05). CONCLUSIONS: It can be concluded from the results that an adequate antibody response can be obtained with PCEC vaccine when administered by the TRC regimen even after reducing the quantity of vaccine from 0.2 ml to 0.1 ml per intradermal dose. The feasibility of using this regimen in true post-exposure cases needs to be further evaluated. SN - 1201-9712 UR - https://www.unboundmedicine.com/medline/citation/15109593/Simulated_post_exposure_rabies_vaccination_with_purified_chick_embryo_cell_vaccine_using_a_modified_Thai_Red_Cross_regimen_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201971204000037 DB - PRIME DP - Unbound Medicine ER -