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Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection.
Neuroimage 2004; 22(1):83-94N

Abstract

fMRI and EEG are complimentary methods for the analysis of brain activity since each method has its strength where the other one has limits: The spatial resolution is thus in the range of millimeters with fMRI and the time resolution is in the range of milliseconds with EEG. For a comprehensive understanding of brain activity in target detection, nine healthy subjects (age 24.2 +/- 2.9) were investigated with simultaneous EEG (27 electrodes) and fMRI using an auditory oddball paradigm. As a first step, event-related potentials, measured inside the scanner, have been compared with the potentials recorded in a directly preceding session in front of the scanner. Attenuated amplitudes were found inside the scanner for the earlier N1/P2 component but not for the late P300 component. Second, an independent analysis of the localizations of the fMRI activations and the current source density as revealed by low resolution electromagnetic tomography (LORETA) has been done. Concordant activations were found in most regions, including the temporoparietal junction (TPJ), the supplementary motor area (SMA)/anterior cingulate cortex (ACC), the insula, and the middle frontal gyrus, with a mean Euclidean distance of 16.0 +/- 6.6 mm between the BOLD centers of gravity and the LORETA-maxima. Finally, a time-course analysis based on the current source density maxima was done. It revealed different time-course patterns in the left and right hemisphere with earlier activations in frontal and parietal regions in the right hemisphere. The results suggest that the combination of EEG and fMRI permits an improved understanding of the spatiotemporal dynamics of brain activity.

Authors+Show Affiliations

Department of Psychiatry, LMU, Nussbaumstrasse 7, 80336 Munich, Germany. cmulert@psy.med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15109999

Citation

Mulert, Christoph, et al. "Integration of fMRI and Simultaneous EEG: Towards a Comprehensive Understanding of Localization and Time-course of Brain Activity in Target Detection." NeuroImage, vol. 22, no. 1, 2004, pp. 83-94.
Mulert C, Jäger L, Schmitt R, et al. Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection. Neuroimage. 2004;22(1):83-94.
Mulert, C., Jäger, L., Schmitt, R., Bussfeld, P., Pogarell, O., Möller, H. J., ... Hegerl, U. (2004). Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection. NeuroImage, 22(1), pp. 83-94.
Mulert C, et al. Integration of fMRI and Simultaneous EEG: Towards a Comprehensive Understanding of Localization and Time-course of Brain Activity in Target Detection. Neuroimage. 2004;22(1):83-94. PubMed PMID: 15109999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection. AU - Mulert,Christoph, AU - Jäger,Lorenz, AU - Schmitt,Robert, AU - Bussfeld,Patrick, AU - Pogarell,Oliver, AU - Möller,Hans-Jürgen, AU - Juckel,Georg, AU - Hegerl,Ulrich, PY - 2003/05/06/received PY - 2003/10/29/revised PY - 2003/10/29/accepted PY - 2004/4/28/pubmed PY - 2004/6/23/medline PY - 2004/4/28/entrez SP - 83 EP - 94 JF - NeuroImage JO - Neuroimage VL - 22 IS - 1 N2 - fMRI and EEG are complimentary methods for the analysis of brain activity since each method has its strength where the other one has limits: The spatial resolution is thus in the range of millimeters with fMRI and the time resolution is in the range of milliseconds with EEG. For a comprehensive understanding of brain activity in target detection, nine healthy subjects (age 24.2 +/- 2.9) were investigated with simultaneous EEG (27 electrodes) and fMRI using an auditory oddball paradigm. As a first step, event-related potentials, measured inside the scanner, have been compared with the potentials recorded in a directly preceding session in front of the scanner. Attenuated amplitudes were found inside the scanner for the earlier N1/P2 component but not for the late P300 component. Second, an independent analysis of the localizations of the fMRI activations and the current source density as revealed by low resolution electromagnetic tomography (LORETA) has been done. Concordant activations were found in most regions, including the temporoparietal junction (TPJ), the supplementary motor area (SMA)/anterior cingulate cortex (ACC), the insula, and the middle frontal gyrus, with a mean Euclidean distance of 16.0 +/- 6.6 mm between the BOLD centers of gravity and the LORETA-maxima. Finally, a time-course analysis based on the current source density maxima was done. It revealed different time-course patterns in the left and right hemisphere with earlier activations in frontal and parietal regions in the right hemisphere. The results suggest that the combination of EEG and fMRI permits an improved understanding of the spatiotemporal dynamics of brain activity. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/15109999/Integration_of_fMRI_and_simultaneous_EEG:_towards_a_comprehensive_understanding_of_localization_and_time_course_of_brain_activity_in_target_detection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053811904000084 DB - PRIME DP - Unbound Medicine ER -