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Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners.
Free Radic Biol Med. 2004 May 15; 36(10):1329-41.FR

Abstract

To determine if 6 weeks of supplementation with vitamins E and C could alleviate exercise-induced lipid peroxidation and inflammation, we studied 22 runners during a 50 km ultramarathon. Subjects were randomly assigned to one of two groups: (1) placebos (PL) or (2) antioxidants (AO: 1000 mg vitamin C and 300 mg RRR-alpha-tocopheryl acetate). Blood samples were obtained prior to supplementation (baseline), after 3 weeks of supplementation, 1 h pre-, mid-, and postrace, 2 h postrace and for 6 days postrace. Plasma levels of alpha-tocopherol (alpha-TOH), ascorbic acid (AA), uric acid (UA), F2-isoprostanes (F2-IsoPs), tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP) were measured. With supplementation, plasma alpha-TOH and AA increased in the AO but not the PL group. Although F2-IsoP levels were similar between groups at baseline, 28 +/- 2 (PL) and 27 +/- 3 pg/ml (AO), F2-IsoPs increased during the run only in the PL group (41 +/- 3 pg/ml). In PL women, F2-IsoPs were elevated postrace (p <.01), but returned to prerace concentrations by 2 h postrace. In PL men, F2-IsoP concentrations were higher postrace, 2 h postrace, and 1, 2, 3, 4, and 6 days postrace (PL vs. AO group, each p <.03). Markers of inflammation were increased dramatically in response to the run regardless of treatment group. Thus, AO supplementation prevented endurance exercise-induced lipid peroxidation but had no effect on inflammatory markers.

Authors+Show Affiliations

Departments of Exercise and Sport Science, Oregon State University, Corvallis, OR 97731, USA. mastaloa@onid.orst.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15110397

Citation

Mastaloudis, Angela, et al. "Antioxidant Supplementation Prevents Exercise-induced Lipid Peroxidation, but Not Inflammation, in Ultramarathon Runners." Free Radical Biology & Medicine, vol. 36, no. 10, 2004, pp. 1329-41.
Mastaloudis A, Morrow JD, Hopkins DW, et al. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic Biol Med. 2004;36(10):1329-41.
Mastaloudis, A., Morrow, J. D., Hopkins, D. W., Devaraj, S., & Traber, M. G. (2004). Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radical Biology & Medicine, 36(10), 1329-41.
Mastaloudis A, et al. Antioxidant Supplementation Prevents Exercise-induced Lipid Peroxidation, but Not Inflammation, in Ultramarathon Runners. Free Radic Biol Med. 2004 May 15;36(10):1329-41. PubMed PMID: 15110397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. AU - Mastaloudis,Angela, AU - Morrow,Jason D, AU - Hopkins,Dawn W, AU - Devaraj,Sridevi, AU - Traber,Maret G, PY - 2004/01/26/received PY - 2004/02/19/accepted PY - 2004/4/28/pubmed PY - 2004/12/16/medline PY - 2004/4/28/entrez SP - 1329 EP - 41 JF - Free radical biology & medicine JO - Free Radic Biol Med VL - 36 IS - 10 N2 - To determine if 6 weeks of supplementation with vitamins E and C could alleviate exercise-induced lipid peroxidation and inflammation, we studied 22 runners during a 50 km ultramarathon. Subjects were randomly assigned to one of two groups: (1) placebos (PL) or (2) antioxidants (AO: 1000 mg vitamin C and 300 mg RRR-alpha-tocopheryl acetate). Blood samples were obtained prior to supplementation (baseline), after 3 weeks of supplementation, 1 h pre-, mid-, and postrace, 2 h postrace and for 6 days postrace. Plasma levels of alpha-tocopherol (alpha-TOH), ascorbic acid (AA), uric acid (UA), F2-isoprostanes (F2-IsoPs), tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP) were measured. With supplementation, plasma alpha-TOH and AA increased in the AO but not the PL group. Although F2-IsoP levels were similar between groups at baseline, 28 +/- 2 (PL) and 27 +/- 3 pg/ml (AO), F2-IsoPs increased during the run only in the PL group (41 +/- 3 pg/ml). In PL women, F2-IsoPs were elevated postrace (p <.01), but returned to prerace concentrations by 2 h postrace. In PL men, F2-IsoP concentrations were higher postrace, 2 h postrace, and 1, 2, 3, 4, and 6 days postrace (PL vs. AO group, each p <.03). Markers of inflammation were increased dramatically in response to the run regardless of treatment group. Thus, AO supplementation prevented endurance exercise-induced lipid peroxidation but had no effect on inflammatory markers. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/15110397/Antioxidant_supplementation_prevents_exercise_induced_lipid_peroxidation_but_not_inflammation_in_ultramarathon_runners_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S089158490400187X DB - PRIME DP - Unbound Medicine ER -