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Prevention of oral mucositis in paediatric patients treated with chemotherapy; a randomised crossover trial comparing two protocols of oral care.
Eur J Cancer 2004; 40(8):1208-16EJ

Abstract

This study compared the efficacy of two protocols for oral care using either chlorhexidine or benzydamine as oral rinses to alleviate mucositis in children undergoing chemotherapy. Eligible participants were randomised to receive either protocol for 3 weeks in a two-period crossover design. The occurrence of ulcerative lesions and severity of mucositis were measured at baseline and twice weekly, using the modified Oral Assessment Guide (OAG). Data were continuously analysed by plotting them directly on predefined sequential charts. According to this sequential analysis, the study could be terminated at the 34th within subject comparison, with a statistically significant reduction in ulcerative lesions (P<0.05) and severity of mucositis (P<0.05) in children on the chlorhexidine protocol. These findings suggest that chlorhexidine together with oral care might be helpful in alleviating mucositis when given prophylactically to children on chemotherapy, but the therapeutic benefit needs to be confirmed in a larger trial.

Authors+Show Affiliations

Nethersole School of Nursing, Faculty of Medicine, Room 804A, Esther Lee Building, Chung Chi College, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. kariskwong@cuhk.edu.hkNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15110885

Citation

Cheng, K K F., et al. "Prevention of Oral Mucositis in Paediatric Patients Treated With Chemotherapy; a Randomised Crossover Trial Comparing Two Protocols of Oral Care." European Journal of Cancer (Oxford, England : 1990), vol. 40, no. 8, 2004, pp. 1208-16.
Cheng KK, Chang AM, Yuen MP. Prevention of oral mucositis in paediatric patients treated with chemotherapy; a randomised crossover trial comparing two protocols of oral care. Eur J Cancer. 2004;40(8):1208-16.
Cheng, K. K., Chang, A. M., & Yuen, M. P. (2004). Prevention of oral mucositis in paediatric patients treated with chemotherapy; a randomised crossover trial comparing two protocols of oral care. European Journal of Cancer (Oxford, England : 1990), 40(8), pp. 1208-16.
Cheng KK, Chang AM, Yuen MP. Prevention of Oral Mucositis in Paediatric Patients Treated With Chemotherapy; a Randomised Crossover Trial Comparing Two Protocols of Oral Care. Eur J Cancer. 2004;40(8):1208-16. PubMed PMID: 15110885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of oral mucositis in paediatric patients treated with chemotherapy; a randomised crossover trial comparing two protocols of oral care. AU - Cheng,K K F, AU - Chang,A M, AU - Yuen,M P, PY - 2002/08/19/received PY - 2003/07/24/revised PY - 2003/10/21/accepted PY - 2004/4/28/pubmed PY - 2004/6/23/medline PY - 2004/4/28/entrez SP - 1208 EP - 16 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 40 IS - 8 N2 - This study compared the efficacy of two protocols for oral care using either chlorhexidine or benzydamine as oral rinses to alleviate mucositis in children undergoing chemotherapy. Eligible participants were randomised to receive either protocol for 3 weeks in a two-period crossover design. The occurrence of ulcerative lesions and severity of mucositis were measured at baseline and twice weekly, using the modified Oral Assessment Guide (OAG). Data were continuously analysed by plotting them directly on predefined sequential charts. According to this sequential analysis, the study could be terminated at the 34th within subject comparison, with a statistically significant reduction in ulcerative lesions (P<0.05) and severity of mucositis (P<0.05) in children on the chlorhexidine protocol. These findings suggest that chlorhexidine together with oral care might be helpful in alleviating mucositis when given prophylactically to children on chemotherapy, but the therapeutic benefit needs to be confirmed in a larger trial. SN - 0959-8049 UR - https://www.unboundmedicine.com/medline/citation/15110885/Prevention_of_oral_mucositis_in_paediatric_patients_treated_with_chemotherapy L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959804903009626 DB - PRIME DP - Unbound Medicine ER -