Tags

Type your tag names separated by a space and hit enter

Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene.
Eur J Cancer 2004; 40(8):1250-4EJ

Abstract

Breast cancer risk may be associated with folate status or the C677T genotype of the methylenetetrahydrofolate reductase (MTHFR) gene. We compared serum folate concentrations and C677T genotype in 141 breast cancer patients and 109 age-matched controls. Serum folate was significantly lower in cases compared to controls (geometric means, 5.7 versus 6.6 microg/l; P=0.005). Breast cancer risk was not associated with C677T genotype. After adjusting for age of menarche, parity, alcohol intake and total fat intake we observed reductions in odds ratios for breast cancer risk comparing the highest with the lowest quartiles of serum folate concentrations of 0.23 (95% confidence interval (CI) 0.09, 0.54) for the entire group, 0.27 (CI 0.09, 0.80) for the wild-type and 0.08 (CI 0.01, 0.52) for the heterozygous C677T genotype. We conclude that for the whole group, and the wild-type and heterozygous C677T genotypes, increased serum concentrations of folate were associated with reduced risks of breast cancer.

Authors+Show Affiliations

Clinical Biochemistry, PathCentre Locked Bag 2009, Nedlands, Western Australia 6009, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15110890

Citation

Beilby, J, et al. "Reduced Breast Cancer Risk With Increasing Serum Folate in a Case-control Study of the C677T Genotype of the Methylenetetrahydrofolate Reductase Gene." European Journal of Cancer (Oxford, England : 1990), vol. 40, no. 8, 2004, pp. 1250-4.
Beilby J, Ingram D, Hähnel R, et al. Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene. Eur J Cancer. 2004;40(8):1250-4.
Beilby, J., Ingram, D., Hähnel, R., & Rossi, E. (2004). Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene. European Journal of Cancer (Oxford, England : 1990), 40(8), pp. 1250-4.
Beilby J, et al. Reduced Breast Cancer Risk With Increasing Serum Folate in a Case-control Study of the C677T Genotype of the Methylenetetrahydrofolate Reductase Gene. Eur J Cancer. 2004;40(8):1250-4. PubMed PMID: 15110890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene. AU - Beilby,J, AU - Ingram,D, AU - Hähnel,R, AU - Rossi,E, PY - 2003/09/30/received PY - 2004/01/12/revised PY - 2004/01/21/accepted PY - 2004/4/28/pubmed PY - 2004/6/23/medline PY - 2004/4/28/entrez SP - 1250 EP - 4 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 40 IS - 8 N2 - Breast cancer risk may be associated with folate status or the C677T genotype of the methylenetetrahydrofolate reductase (MTHFR) gene. We compared serum folate concentrations and C677T genotype in 141 breast cancer patients and 109 age-matched controls. Serum folate was significantly lower in cases compared to controls (geometric means, 5.7 versus 6.6 microg/l; P=0.005). Breast cancer risk was not associated with C677T genotype. After adjusting for age of menarche, parity, alcohol intake and total fat intake we observed reductions in odds ratios for breast cancer risk comparing the highest with the lowest quartiles of serum folate concentrations of 0.23 (95% confidence interval (CI) 0.09, 0.54) for the entire group, 0.27 (CI 0.09, 0.80) for the wild-type and 0.08 (CI 0.01, 0.52) for the heterozygous C677T genotype. We conclude that for the whole group, and the wild-type and heterozygous C677T genotypes, increased serum concentrations of folate were associated with reduced risks of breast cancer. SN - 0959-8049 UR - https://www.unboundmedicine.com/medline/citation/15110890/Reduced_breast_cancer_risk_with_increasing_serum_folate_in_a_case_control_study_of_the_C677T_genotype_of_the_methylenetetrahydrofolate_reductase_gene_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959804904001649 DB - PRIME DP - Unbound Medicine ER -