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Dietary factors and the risk of incident kidney stones in younger women: Nurses' Health Study II.

Abstract

BACKGROUND

In older women and men, greater intakes of dietary calcium, potassium, and total fluid reduce the risk of kidney stone formation, while supplemental calcium, sodium, animal protein, and sucrose may increase the risk. Recently, phytate has been suggested to play a role in stone formation. To our knowledge, no prospective information on the role of dietary factors and risk of kidney stone formation is available in younger women.

METHODS

We prospectively examined, during an 8-year period, the association between dietary factors and the risk of incident symptomatic kidney stones among 96 245 female participants in the Nurses' Health Study II; the participants were aged 27 to 44 years and had no history of kidney stones. Self-administered food frequency questionnaires were used to assess diet in 1991 and 1995. The main outcome measure was an incident symptomatic kidney stone. Cox proportional hazards regression models were used to adjust simultaneously for various risk factors.

RESULTS

We documented 1223 incident symptomatic kidney stones during 685 973 person-years of follow-up. After adjusting for relevant risk factors, a higher dietary calcium intake was associated with a reduced risk of kidney stones (P =.007 for trend). The multivariate relative risk among women in the highest quintile of intake of dietary calcium compared with women in the lowest quintile was 0.73 (95% confidence interval, 0.59-0.90). Supplemental calcium intake was not associated with risk of stone formation. Phytate intake was associated with a reduced risk of stone formation. Compared with women in the lowest quintile of phytate intake, the relative risk for those in the highest quintile was 0.63 (95% confidence interval, 0.51-0.78). Other dietary factors showed the following relative risks (95% confidence intervals) among women in the highest quintile of intake compared with those in the lowest quintile: animal protein, 0.84 (0.68-1.04); fluid, 0.68 (0.56-0.83); and sucrose, 1.31 (1.07-1.60). The intakes of sodium, potassium, and magnesium were not independently associated with risk after adjusting for other dietary factors.

CONCLUSIONS

A higher intake of dietary calcium decreases the risk of kidney stone formation in younger women, but supplemental calcium is not associated with risk. This study also suggests that some dietary risk factors may differ by age and sex. Finally, dietary phytate may be a new, important, and safe addition to our options for stone prevention.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Brigham and Womens' Hospital, 181 Longwood Avenue, Boston, MA 02115, USA. Gary.Curhan@channing.harvard.edu

    , ,

    Source

    Archives of internal medicine 164:8 2004 Apr 26 pg 885-91

    MeSH

    Adult
    Calcium, Dietary
    Diet
    Dietary Proteins
    Female
    Humans
    Kidney Calculi
    Phytic Acid
    Proportional Hazards Models
    Prospective Studies

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15111375

    Citation

    Curhan, Gary C., et al. "Dietary Factors and the Risk of Incident Kidney Stones in Younger Women: Nurses' Health Study II." Archives of Internal Medicine, vol. 164, no. 8, 2004, pp. 885-91.
    Curhan GC, Willett WC, Knight EL, et al. Dietary factors and the risk of incident kidney stones in younger women: Nurses' Health Study II. Arch Intern Med. 2004;164(8):885-91.
    Curhan, G. C., Willett, W. C., Knight, E. L., & Stampfer, M. J. (2004). Dietary factors and the risk of incident kidney stones in younger women: Nurses' Health Study II. Archives of Internal Medicine, 164(8), pp. 885-91.
    Curhan GC, et al. Dietary Factors and the Risk of Incident Kidney Stones in Younger Women: Nurses' Health Study II. Arch Intern Med. 2004 Apr 26;164(8):885-91. PubMed PMID: 15111375.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary factors and the risk of incident kidney stones in younger women: Nurses' Health Study II. AU - Curhan,Gary C, AU - Willett,Walter C, AU - Knight,Eric L, AU - Stampfer,Meir J, PY - 2004/4/28/pubmed PY - 2004/5/22/medline PY - 2004/4/28/entrez SP - 885 EP - 91 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 164 IS - 8 N2 - BACKGROUND: In older women and men, greater intakes of dietary calcium, potassium, and total fluid reduce the risk of kidney stone formation, while supplemental calcium, sodium, animal protein, and sucrose may increase the risk. Recently, phytate has been suggested to play a role in stone formation. To our knowledge, no prospective information on the role of dietary factors and risk of kidney stone formation is available in younger women. METHODS: We prospectively examined, during an 8-year period, the association between dietary factors and the risk of incident symptomatic kidney stones among 96 245 female participants in the Nurses' Health Study II; the participants were aged 27 to 44 years and had no history of kidney stones. Self-administered food frequency questionnaires were used to assess diet in 1991 and 1995. The main outcome measure was an incident symptomatic kidney stone. Cox proportional hazards regression models were used to adjust simultaneously for various risk factors. RESULTS: We documented 1223 incident symptomatic kidney stones during 685 973 person-years of follow-up. After adjusting for relevant risk factors, a higher dietary calcium intake was associated with a reduced risk of kidney stones (P =.007 for trend). The multivariate relative risk among women in the highest quintile of intake of dietary calcium compared with women in the lowest quintile was 0.73 (95% confidence interval, 0.59-0.90). Supplemental calcium intake was not associated with risk of stone formation. Phytate intake was associated with a reduced risk of stone formation. Compared with women in the lowest quintile of phytate intake, the relative risk for those in the highest quintile was 0.63 (95% confidence interval, 0.51-0.78). Other dietary factors showed the following relative risks (95% confidence intervals) among women in the highest quintile of intake compared with those in the lowest quintile: animal protein, 0.84 (0.68-1.04); fluid, 0.68 (0.56-0.83); and sucrose, 1.31 (1.07-1.60). The intakes of sodium, potassium, and magnesium were not independently associated with risk after adjusting for other dietary factors. CONCLUSIONS: A higher intake of dietary calcium decreases the risk of kidney stone formation in younger women, but supplemental calcium is not associated with risk. This study also suggests that some dietary risk factors may differ by age and sex. Finally, dietary phytate may be a new, important, and safe addition to our options for stone prevention. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15111375/Dietary_factors_and_the_risk_of_incident_kidney_stones_in_younger_women:_Nurses'_Health_Study_II_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.164.8.885 DB - PRIME DP - Unbound Medicine ER -