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Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation.
Arch Intern Med 2004; 164(8):892-6AI

Abstract

BACKGROUND

Sedentary lifestyle, obesity, and impaired glucose regulation are associated with the risk of type 2 diabetes. However, the joint associations of these risk factors are not known.

METHODS

We prospectively followed up 2017 Finnish men and 2352 Finnish women aged between 45 and 64 years without a history of known or newly diagnosed diabetes at baseline. Single and joint associations of physical activity, body mass index (BMI), and blood glucose levels with risk of type 2 diabetes were examined using Cox proportional hazards models.

RESULTS

During a mean follow-up of 9.4 years, there were 120 incident cases of type 2 diabetes. After adjustment for confounding factors (age, study year, sex, systolic blood pressure, smoking, and education), physical activity was found to be inversely associated with the risk of type 2 diabetes. This association was persistent in subjects with (1) both obesity and impaired glucose regulation, (2) either obesity or impaired glucose regulation, and (3) a normal BMI and glucose regulation. Similarly, the multivariate-adjusted positive association between BMI and risk of type 2 diabetes was consistently observed. Obesity in subjects who reported being inactive and had normal glucose levels was associated with an increased risk of diabetes compared with a normal BMI in subjects who reported being active and had impaired glucose regulation.

CONCLUSIONS

Increasing physical activity can reduce the risk of type 2 diabetes. The protective effect of physical activity was observed in subjects with an excessive BMI and elevated glucose levels. Physical activity and weight control are critical factors in diabetes prevention in subjects with both normal and impaired blood glucose regulation.

Authors+Show Affiliations

Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. hu.gang@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15111376

Citation

Hu, Gang, et al. "Physical Activity, Body Mass Index, and Risk of Type 2 Diabetes in Patients With Normal or Impaired Glucose Regulation." Archives of Internal Medicine, vol. 164, no. 8, 2004, pp. 892-6.
Hu G, Lindström J, Valle TT, et al. Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Arch Intern Med. 2004;164(8):892-6.
Hu, G., Lindström, J., Valle, T. T., Eriksson, J. G., Jousilahti, P., Silventoinen, K., ... Tuomilehto, J. (2004). Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Archives of Internal Medicine, 164(8), pp. 892-6.
Hu G, et al. Physical Activity, Body Mass Index, and Risk of Type 2 Diabetes in Patients With Normal or Impaired Glucose Regulation. Arch Intern Med. 2004 Apr 26;164(8):892-6. PubMed PMID: 15111376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. AU - Hu,Gang, AU - Lindström,Jaana, AU - Valle,Timo T, AU - Eriksson,Johan G, AU - Jousilahti,Pekka, AU - Silventoinen,Karri, AU - Qiao,Qing, AU - Tuomilehto,Jaakko, PY - 2004/4/28/pubmed PY - 2004/5/22/medline PY - 2004/4/28/entrez SP - 892 EP - 6 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 164 IS - 8 N2 - BACKGROUND: Sedentary lifestyle, obesity, and impaired glucose regulation are associated with the risk of type 2 diabetes. However, the joint associations of these risk factors are not known. METHODS: We prospectively followed up 2017 Finnish men and 2352 Finnish women aged between 45 and 64 years without a history of known or newly diagnosed diabetes at baseline. Single and joint associations of physical activity, body mass index (BMI), and blood glucose levels with risk of type 2 diabetes were examined using Cox proportional hazards models. RESULTS: During a mean follow-up of 9.4 years, there were 120 incident cases of type 2 diabetes. After adjustment for confounding factors (age, study year, sex, systolic blood pressure, smoking, and education), physical activity was found to be inversely associated with the risk of type 2 diabetes. This association was persistent in subjects with (1) both obesity and impaired glucose regulation, (2) either obesity or impaired glucose regulation, and (3) a normal BMI and glucose regulation. Similarly, the multivariate-adjusted positive association between BMI and risk of type 2 diabetes was consistently observed. Obesity in subjects who reported being inactive and had normal glucose levels was associated with an increased risk of diabetes compared with a normal BMI in subjects who reported being active and had impaired glucose regulation. CONCLUSIONS: Increasing physical activity can reduce the risk of type 2 diabetes. The protective effect of physical activity was observed in subjects with an excessive BMI and elevated glucose levels. Physical activity and weight control are critical factors in diabetes prevention in subjects with both normal and impaired blood glucose regulation. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15111376/Physical_activity_body_mass_index_and_risk_of_type_2_diabetes_in_patients_with_normal_or_impaired_glucose_regulation_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.164.8.892 DB - PRIME DP - Unbound Medicine ER -