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Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center.
Invest Ophthalmol Vis Sci 2004; 45(5):1306-10IO

Abstract

PURPOSE

To examine the effect of apolipoprotein E (APOE) alleles on age-related macular degeneration (AMD) risk and on age at diagnosis of AMD in a large patient cohort recruited from a single center.

METHODS

The frequency of APOE alleles was analyzed in 632 unrelated AMD patients and 206 unrelated controls, all of whom were of white ancestry. The presence or absence of disease symptoms in all patients and controls was based on clinical examination and/or ophthalmic records. The association with APOE was explored in the context of AMD subtypes, family history status, possible interaction with smoking, and distribution of age at diagnosis of AMD.

RESULTS

The frequency of the epsilon4 allele was significantly reduced in patients compared with controls (0.10 vs. 0.14, P < or = 0.02). Gender- and age-adjusted odds ratios indicated that epsilon4-carriers have significantly lower risk of developing AMD compared to epsilon3epsilon3 subjects (OR = 0.55, 95% CI: 0.37-0.82, P = 0.004). In the cohort, AMD patients with a positive family history exhibited a significant 3.5 years earlier age at diagnosis (P = 0.001); however, APOE alleles did not appear to modulate the age at diagnosis of AMD.

CONCLUSIONS

The association between the APOE-epsilon4 allele and a reduced risk of AMD was established in a large cohort with sufficient statistical power. How distinct APOE alleles affect AMD susceptibility warrants further investigation.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15111581

Citation

Zareparsi, Sepideh, et al. "Association of Apolipoprotein E Alleles With Susceptibility to Age-related Macular Degeneration in a Large Cohort From a Single Center." Investigative Ophthalmology & Visual Science, vol. 45, no. 5, 2004, pp. 1306-10.
Zareparsi S, Reddick AC, Branham KE, et al. Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center. Invest Ophthalmol Vis Sci. 2004;45(5):1306-10.
Zareparsi, S., Reddick, A. C., Branham, K. E., Moore, K. B., Jessup, L., Thoms, S., ... Swaroop, A. (2004). Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center. Investigative Ophthalmology & Visual Science, 45(5), pp. 1306-10.
Zareparsi S, et al. Association of Apolipoprotein E Alleles With Susceptibility to Age-related Macular Degeneration in a Large Cohort From a Single Center. Invest Ophthalmol Vis Sci. 2004;45(5):1306-10. PubMed PMID: 15111581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center. AU - Zareparsi,Sepideh, AU - Reddick,Adam C, AU - Branham,Kari E H, AU - Moore,Kathryn B, AU - Jessup,Laurie, AU - Thoms,Susan, AU - Smith-Wheelock,Michael, AU - Yashar,Beverly M, AU - Swaroop,Anand, PY - 2004/4/28/pubmed PY - 2004/5/28/medline PY - 2004/4/28/entrez SP - 1306 EP - 10 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 45 IS - 5 N2 - PURPOSE: To examine the effect of apolipoprotein E (APOE) alleles on age-related macular degeneration (AMD) risk and on age at diagnosis of AMD in a large patient cohort recruited from a single center. METHODS: The frequency of APOE alleles was analyzed in 632 unrelated AMD patients and 206 unrelated controls, all of whom were of white ancestry. The presence or absence of disease symptoms in all patients and controls was based on clinical examination and/or ophthalmic records. The association with APOE was explored in the context of AMD subtypes, family history status, possible interaction with smoking, and distribution of age at diagnosis of AMD. RESULTS: The frequency of the epsilon4 allele was significantly reduced in patients compared with controls (0.10 vs. 0.14, P < or = 0.02). Gender- and age-adjusted odds ratios indicated that epsilon4-carriers have significantly lower risk of developing AMD compared to epsilon3epsilon3 subjects (OR = 0.55, 95% CI: 0.37-0.82, P = 0.004). In the cohort, AMD patients with a positive family history exhibited a significant 3.5 years earlier age at diagnosis (P = 0.001); however, APOE alleles did not appear to modulate the age at diagnosis of AMD. CONCLUSIONS: The association between the APOE-epsilon4 allele and a reduced risk of AMD was established in a large cohort with sufficient statistical power. How distinct APOE alleles affect AMD susceptibility warrants further investigation. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/15111581/Association_of_apolipoprotein_E_alleles_with_susceptibility_to_age_related_macular_degeneration_in_a_large_cohort_from_a_single_center_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.03-1253 DB - PRIME DP - Unbound Medicine ER -