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Efficacy of daily and weekly iron supplementation on iron status in exclusively breast-fed infants.

Abstract

Iron deficiency anemia (IDA) remains the most prevalent nutritional deficiency in infants worldwide. The purpose of this study was to determine the efficacy of daily and weekly iron supplementation for 3 months to improve the iron status in 4-month-old, exclusively breast-fed healthy infants. Infants 4 months of age were eligible for the open, randomized controlled trial if their mothers intended to continue exclusive breast-feeding until the infants were 6 months of age. Infants or mothers with iron deficiency (ID) or IDA on admission were excluded. The infants (n = 79) were randomly assigned to three groups, the first group receiving daily (1 mg/kg daily), the second group weekly (7 mg/kg weekly), and the third group no iron supplementation. Anthropometric measurements were taken on admission and at 6 and 7 months of age. Iron status was analyzed on admission and monthly for 3 months. Both hematologic parameters and anthropometric measurements were found to be similar among the three groups during the study period. Seven infants (31.8%) in the control group, six (26.0%) in the daily group, and three (13.6%) in the weekly group developed ID or IDA (P > 0.05). Infants whose mothers had ID or IDA during the study period were more likely to develop ID or IDA independently from iron supplementation. Serum ferritin levels decreased between 4 and 6 months of age in the control and daily groups; the weekly group showed no such decrease. In all groups, the mean levels of serum ferritin were significantly increased from 6 months to 7 months of age during the weaning period. In this study, which had a limited number of cases, weekly or daily iron supplementation was not found to decrease the likelihood of IDA. In conclusion, exclusively breast-fed infants with maternal IDA appeared to be at increased risk of developing IDA.

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  • Authors+Show Affiliations

    ,

    Department of Social Pediatrics, Institute of Child Health, Hacettepe University, Ankara, Turkey. siyalcin@hacettepe.edu.tr

    , ,

    Source

    MeSH

    Adult
    Age Factors
    Anemia, Iron-Deficiency
    Body Weights and Measures
    Breast Feeding
    Dietary Supplements
    Drug Administration Schedule
    Female
    Ferritins
    Humans
    Infant
    Iron
    Male
    Mothers
    Risk Factors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    15111779

    Citation

    Yurdakök, Kadriye, et al. "Efficacy of Daily and Weekly Iron Supplementation On Iron Status in Exclusively Breast-fed Infants." Journal of Pediatric Hematology/oncology, vol. 26, no. 5, 2004, pp. 284-8.
    Yurdakök K, Temiz F, Yalçin SS, et al. Efficacy of daily and weekly iron supplementation on iron status in exclusively breast-fed infants. J Pediatr Hematol Oncol. 2004;26(5):284-8.
    Yurdakök, K., Temiz, F., Yalçin, S. S., & Gümrük, F. (2004). Efficacy of daily and weekly iron supplementation on iron status in exclusively breast-fed infants. Journal of Pediatric Hematology/oncology, 26(5), pp. 284-8.
    Yurdakök K, et al. Efficacy of Daily and Weekly Iron Supplementation On Iron Status in Exclusively Breast-fed Infants. J Pediatr Hematol Oncol. 2004;26(5):284-8. PubMed PMID: 15111779.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Efficacy of daily and weekly iron supplementation on iron status in exclusively breast-fed infants. AU - Yurdakök,Kadriye, AU - Temiz,Fatih, AU - Yalçin,S Songül, AU - Gümrük,Fatma, PY - 2004/4/28/pubmed PY - 2004/6/16/medline PY - 2004/4/28/entrez SP - 284 EP - 8 JF - Journal of pediatric hematology/oncology JO - J. Pediatr. Hematol. Oncol. VL - 26 IS - 5 N2 - Iron deficiency anemia (IDA) remains the most prevalent nutritional deficiency in infants worldwide. The purpose of this study was to determine the efficacy of daily and weekly iron supplementation for 3 months to improve the iron status in 4-month-old, exclusively breast-fed healthy infants. Infants 4 months of age were eligible for the open, randomized controlled trial if their mothers intended to continue exclusive breast-feeding until the infants were 6 months of age. Infants or mothers with iron deficiency (ID) or IDA on admission were excluded. The infants (n = 79) were randomly assigned to three groups, the first group receiving daily (1 mg/kg daily), the second group weekly (7 mg/kg weekly), and the third group no iron supplementation. Anthropometric measurements were taken on admission and at 6 and 7 months of age. Iron status was analyzed on admission and monthly for 3 months. Both hematologic parameters and anthropometric measurements were found to be similar among the three groups during the study period. Seven infants (31.8%) in the control group, six (26.0%) in the daily group, and three (13.6%) in the weekly group developed ID or IDA (P > 0.05). Infants whose mothers had ID or IDA during the study period were more likely to develop ID or IDA independently from iron supplementation. Serum ferritin levels decreased between 4 and 6 months of age in the control and daily groups; the weekly group showed no such decrease. In all groups, the mean levels of serum ferritin were significantly increased from 6 months to 7 months of age during the weaning period. In this study, which had a limited number of cases, weekly or daily iron supplementation was not found to decrease the likelihood of IDA. In conclusion, exclusively breast-fed infants with maternal IDA appeared to be at increased risk of developing IDA. SN - 1077-4114 UR - https://www.unboundmedicine.com/medline/citation/15111779/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=15111779 DB - PRIME DP - Unbound Medicine ER -