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IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome.
In Vivo. 2004 Mar-Apr; 18(2):101-6.V

Abstract

BACKGROUND

A unique subset of patients with chronic fatigue syndrome (CFS) and IgM serum antibodies to cytomegalovirus (HCMV) non-structural gene products p52 and CM2 (UL 44 and UL 57) has been described.

PATIENTS AND METHODS

Fifty-eight CFS patients and 68 non-CFS matched controls were studied. Serum antibodies to EBV viral capsid antigen (VCA) IgM and EBV Early Antigen, diffuse (EA, D) as well HVCMV(V), IgM and IgG; VP (sucrose, density purified V); p52 and CM2 IgM serum antibodies were assayed.

RESULTS

Mean age of CFS patients was 44 years (75% women). Control patients were 9 years older (73% women). Serum EBV VCA IgM positive antibody titers were identified in 33 CFS patients (Group A subset EBV VCA IgM 62.3+/-8.3, neg. <20), but were not present in other CFS patients, (Group B subset EBV VCA IgM 6.8+/-0.7) controls (p<0.0001). EBV VCA IgM titers remained positive in CFS patients from Group A for 24-42 months.

CONCLUSION

Serum antibody to EBV VCA IgM may be a specific diagnostic test for a second subset of CFS patients.

Authors+Show Affiliations

Department of Medicine, William Beaumont Hospital and Wayne State University School of Medicine, Royal Oak, Michigan, USA. lerner@cdimed.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15113035

Citation

Lerner, A Martin, et al. "IgM Serum Antibodies to Epstein-Barr Virus Are Uniquely Present in a Subset of Patients With the Chronic Fatigue Syndrome." In Vivo (Athens, Greece), vol. 18, no. 2, 2004, pp. 101-6.
Lerner AM, Beqaj SH, Deeter RG, et al. IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome. In Vivo. 2004;18(2):101-6.
Lerner, A. M., Beqaj, S. H., Deeter, R. G., & Fitzgerald, J. T. (2004). IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome. In Vivo (Athens, Greece), 18(2), 101-6.
Lerner AM, et al. IgM Serum Antibodies to Epstein-Barr Virus Are Uniquely Present in a Subset of Patients With the Chronic Fatigue Syndrome. In Vivo. 2004 Mar-Apr;18(2):101-6. PubMed PMID: 15113035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome. AU - Lerner,A Martin, AU - Beqaj,Safedin H, AU - Deeter,Robert G, AU - Fitzgerald,James T, PY - 2004/4/29/pubmed PY - 2004/11/9/medline PY - 2004/4/29/entrez SP - 101 EP - 6 JF - In vivo (Athens, Greece) JO - In Vivo VL - 18 IS - 2 N2 - BACKGROUND: A unique subset of patients with chronic fatigue syndrome (CFS) and IgM serum antibodies to cytomegalovirus (HCMV) non-structural gene products p52 and CM2 (UL 44 and UL 57) has been described. PATIENTS AND METHODS: Fifty-eight CFS patients and 68 non-CFS matched controls were studied. Serum antibodies to EBV viral capsid antigen (VCA) IgM and EBV Early Antigen, diffuse (EA, D) as well HVCMV(V), IgM and IgG; VP (sucrose, density purified V); p52 and CM2 IgM serum antibodies were assayed. RESULTS: Mean age of CFS patients was 44 years (75% women). Control patients were 9 years older (73% women). Serum EBV VCA IgM positive antibody titers were identified in 33 CFS patients (Group A subset EBV VCA IgM 62.3+/-8.3, neg. <20), but were not present in other CFS patients, (Group B subset EBV VCA IgM 6.8+/-0.7) controls (p<0.0001). EBV VCA IgM titers remained positive in CFS patients from Group A for 24-42 months. CONCLUSION: Serum antibody to EBV VCA IgM may be a specific diagnostic test for a second subset of CFS patients. SN - 0258-851X UR - https://www.unboundmedicine.com/medline/citation/15113035/IgM_serum_antibodies_to_Epstein_Barr_virus_are_uniquely_present_in_a_subset_of_patients_with_the_chronic_fatigue_syndrome_ L2 - http://iv.iiarjournals.org/cgi/pmidlookup?view=long&amp;pmid=15113035 DB - PRIME DP - Unbound Medicine ER -