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Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of diabetic rat myocardium.
Gen Physiol Biophys. 2003 Dec; 22(4):535-47.GP

Abstract

In the present study we investigated the effects of simvastatin treatment on lipid metabolism and peroxidation, antioxidant enzyme activities and ultrastructure of the diabetic rat myocardium. Diabetes was induced by single injection of streptozotocin (45 mg/kg i.p.). Eight weeks after induction of diabetes, a subgroup of control and of diabetic rats was treated with simvastatin for 4 weeks (10 mg/kg/day, orally). Blood glucose, plasma cholesterol and triacylglycerol, as well as levels of cardiac thiobarbituric acid reactive substances (TBARS) were significantly increased in diabetic rats. The activities of antioxidant enzymes, catalase (CAT) and glutathione peroxidase (GSHPx), were also elevated in the diabetic myocardium. Treatment with simvastatin markedly reduced serum triacylglycerol and cholesterol, and partially controlled hyperglycemia in diabetic animals. The increased activation of antioxidant enzymes and the excess of lipid peroxidation measured by TBARS were completely reversed by simvastatin treatment. Diabetic rats displayed ultrastructural ischemia-like alterations of cardiomyocytes and capillaries, which support oxidative stress-induced tissue remodelling. In the diabetic myocardium simvastatin treatment partly attenuated angiopathic and atherogenic processes, detected by electron microscopy. These results suggest that simvastatin, known as a lipid-lowering drug, may positively affect diabetes induced cardiovascular complications via reducing risks of atherosclerotic pathological processes, such as imbalance between oxidant and antioxidant state.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmacy, Ankara University, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15113125

Citation

Ceylan, A, et al. "Effects of Simvastatin Treatment On Oxidant/antioxidant State and Ultrastructure of Diabetic Rat Myocardium." General Physiology and Biophysics, vol. 22, no. 4, 2003, pp. 535-47.
Ceylan A, Karasu C, Aktan F, et al. Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of diabetic rat myocardium. Gen Physiol Biophys. 2003;22(4):535-47.
Ceylan, A., Karasu, C., Aktan, F., Güven, C., Can, B., & Ozansoy, G. (2003). Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of diabetic rat myocardium. General Physiology and Biophysics, 22(4), 535-47.
Ceylan A, et al. Effects of Simvastatin Treatment On Oxidant/antioxidant State and Ultrastructure of Diabetic Rat Myocardium. Gen Physiol Biophys. 2003;22(4):535-47. PubMed PMID: 15113125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of diabetic rat myocardium. AU - Ceylan,A, AU - Karasu,C, AU - Aktan,F, AU - Güven,C, AU - Can,B, AU - Ozansoy,G, PY - 2004/4/29/pubmed PY - 2004/8/25/medline PY - 2004/4/29/entrez SP - 535 EP - 47 JF - General physiology and biophysics JO - Gen Physiol Biophys VL - 22 IS - 4 N2 - In the present study we investigated the effects of simvastatin treatment on lipid metabolism and peroxidation, antioxidant enzyme activities and ultrastructure of the diabetic rat myocardium. Diabetes was induced by single injection of streptozotocin (45 mg/kg i.p.). Eight weeks after induction of diabetes, a subgroup of control and of diabetic rats was treated with simvastatin for 4 weeks (10 mg/kg/day, orally). Blood glucose, plasma cholesterol and triacylglycerol, as well as levels of cardiac thiobarbituric acid reactive substances (TBARS) were significantly increased in diabetic rats. The activities of antioxidant enzymes, catalase (CAT) and glutathione peroxidase (GSHPx), were also elevated in the diabetic myocardium. Treatment with simvastatin markedly reduced serum triacylglycerol and cholesterol, and partially controlled hyperglycemia in diabetic animals. The increased activation of antioxidant enzymes and the excess of lipid peroxidation measured by TBARS were completely reversed by simvastatin treatment. Diabetic rats displayed ultrastructural ischemia-like alterations of cardiomyocytes and capillaries, which support oxidative stress-induced tissue remodelling. In the diabetic myocardium simvastatin treatment partly attenuated angiopathic and atherogenic processes, detected by electron microscopy. These results suggest that simvastatin, known as a lipid-lowering drug, may positively affect diabetes induced cardiovascular complications via reducing risks of atherosclerotic pathological processes, such as imbalance between oxidant and antioxidant state. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/15113125/Effects_of_simvastatin_treatment_on_oxidant/antioxidant_state_and_ultrastructure_of_diabetic_rat_myocardium_ L2 - http://www.gpb.sav.sk/2003_04_535.pdf DB - PRIME DP - Unbound Medicine ER -