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Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil.
J Agric Food Chem. 2004 May 05; 52(9):2485-9.JA

Abstract

The present study describes antimicrobial and free radical scavenging capacity (RSC) together with the effects on lipid peroxidation (LP) of Melissa officinalis essential oil. The chemical profile of essential oil was evaluated by the means of gas chromatography-mass spectrometry (GC-MS) and thin-layer chromatography (TLC). RSC was assessed measuring the scavenging activity of essential oil on the 2,2-diphenyl-1-picrylhydrazyl (DPPH(*)) and OH(*) radicals. The effect on LP was evaluated following the activities on Fe(2+)/ascorbate and Fe(2+)/H(2)O(2) systems of induction. The antimicrobial activity was tested against 13 bacterial strains and six fungi. The examined essential oil exhibited very strong RSC, reducing the DPPH radical formation (IC(50) = 7.58 microg/mL) and OH radical generation (IC(50) = 1.74 microg/mL) in a dose-dependent manner. According to the GC-MS and TLC (dot-blot techniques), the most powerful scavenging compounds were monoterpene aldehydes and ketones (neral/geranial, citronellal, isomenthone, and menthone) and mono- and sesquiterpene hydrocarbons (E-caryophyllene). Very strong inhibition of LP, particularly in the Fe(2+)/H(2)O(2) system of induction (94.59% for 2.13 microg/mL), was observed in both cases, also in a dose-dependent manner. The most effective antibacterial activity was expressed on a multiresistant strain of Shigella sonei. A significant rate of antifungal activity was exhibited on Trichophyton species.

Authors+Show Affiliations

Department of Chemistry, Faculty of Natural Sciences, Trg D. Obradovica 3, University of Novi Sad, 21000 Novi Sad, Serbia and Montenegro. mimica@ih.ns.ac.yuNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15113145

Citation

Mimica-Dukic, Neda, et al. "Antimicrobial and Antioxidant Activities of Melissa Officinalis L. (Lamiaceae) Essential Oil." Journal of Agricultural and Food Chemistry, vol. 52, no. 9, 2004, pp. 2485-9.
Mimica-Dukic N, Bozin B, Sokovic M, et al. Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. J Agric Food Chem. 2004;52(9):2485-9.
Mimica-Dukic, N., Bozin, B., Sokovic, M., & Simin, N. (2004). Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. Journal of Agricultural and Food Chemistry, 52(9), 2485-9.
Mimica-Dukic N, et al. Antimicrobial and Antioxidant Activities of Melissa Officinalis L. (Lamiaceae) Essential Oil. J Agric Food Chem. 2004 May 5;52(9):2485-9. PubMed PMID: 15113145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. AU - Mimica-Dukic,Neda, AU - Bozin,Biljana, AU - Sokovic,Marina, AU - Simin,Natasa, PY - 2004/4/29/pubmed PY - 2004/6/29/medline PY - 2004/4/29/entrez SP - 2485 EP - 9 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 52 IS - 9 N2 - The present study describes antimicrobial and free radical scavenging capacity (RSC) together with the effects on lipid peroxidation (LP) of Melissa officinalis essential oil. The chemical profile of essential oil was evaluated by the means of gas chromatography-mass spectrometry (GC-MS) and thin-layer chromatography (TLC). RSC was assessed measuring the scavenging activity of essential oil on the 2,2-diphenyl-1-picrylhydrazyl (DPPH(*)) and OH(*) radicals. The effect on LP was evaluated following the activities on Fe(2+)/ascorbate and Fe(2+)/H(2)O(2) systems of induction. The antimicrobial activity was tested against 13 bacterial strains and six fungi. The examined essential oil exhibited very strong RSC, reducing the DPPH radical formation (IC(50) = 7.58 microg/mL) and OH radical generation (IC(50) = 1.74 microg/mL) in a dose-dependent manner. According to the GC-MS and TLC (dot-blot techniques), the most powerful scavenging compounds were monoterpene aldehydes and ketones (neral/geranial, citronellal, isomenthone, and menthone) and mono- and sesquiterpene hydrocarbons (E-caryophyllene). Very strong inhibition of LP, particularly in the Fe(2+)/H(2)O(2) system of induction (94.59% for 2.13 microg/mL), was observed in both cases, also in a dose-dependent manner. The most effective antibacterial activity was expressed on a multiresistant strain of Shigella sonei. A significant rate of antifungal activity was exhibited on Trichophyton species. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15113145/Antimicrobial_and_antioxidant_activities_of_Melissa_officinalis_L___Lamiaceae__essential_oil_ L2 - https://doi.org/10.1021/jf030698a DB - PRIME DP - Unbound Medicine ER -