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Dietary fat consumption and primary open-angle glaucoma.
Am J Clin Nutr 2004; 79(5):755-64AJ

Abstract

BACKGROUND

Prostaglandin F(2alpha) analogues are effective intraocular-pressure-lowering drugs. Dietary fatty acids affect endogenous prostaglandin F(2alpha) concentrations and may thus influence intraocular pressure.

OBJECTIVE

We prospectively examined dietary fat consumption in relation to primary open-angle glaucoma (POAG).

DESIGN

Women (n = 76 199 in the Nurses' Health Study) and men (n = 40 306 in the Health Professionals Follow-Up Study) free of POAG in 1980 and 1986, respectively, were followed until 1996 if they were > or =40 y old and reported receiving eye exams during follow-up. Potential confounders were assessed on biennial questionnaires, and energy-adjusted cumulative averaged fat intakes were measured by using validated food-frequency questionnaires. We analyzed 474 self-reported POAG cases confirmed by medical chart review. Cohort-specific multivariate rate ratios (RRs) were obtained by using proportional hazards models and were then pooled.

RESULTS

Major fats and fat subtypes were not independently associated with POAG risk. Pooled multivariate RRs (95% CI) for POAG comparing the highest with the lowest quintile of fat intake were as follows: 0.90 (0.67, 1.21) for total fat, 1.03 (0.77, 1.38) for saturated fat, 0.76 (0.56, 1.03) for monounsaturated fat, and 0.87 (0.66, 1.16) for polyunsaturated fat, none of which were statistically significant. We found a suggestive positive association between a higher ratio of n-3 to n-6 polyunsaturated fat and risk of POAG [RR = 1.49 (1.11, 2.01); P for trend = 0.10], which was stronger for high-tension POAG [RR = 1.68 (1.18, 2.39); P for trend = 0.009].

CONCLUSION

A high ratio of n-3 to n-6 polyunsaturated fat appears to increase the risk of POAG, particularly high-tension POAG. Further studies are needed.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA. nhjhk@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15113712

Citation

Kang, Jae H., et al. "Dietary Fat Consumption and Primary Open-angle Glaucoma." The American Journal of Clinical Nutrition, vol. 79, no. 5, 2004, pp. 755-64.
Kang JH, Pasquale LR, Willett WC, et al. Dietary fat consumption and primary open-angle glaucoma. Am J Clin Nutr. 2004;79(5):755-64.
Kang, J. H., Pasquale, L. R., Willett, W. C., Rosner, B. A., Egan, K. M., Faberowski, N., & Hankinson, S. E. (2004). Dietary fat consumption and primary open-angle glaucoma. The American Journal of Clinical Nutrition, 79(5), pp. 755-64.
Kang JH, et al. Dietary Fat Consumption and Primary Open-angle Glaucoma. Am J Clin Nutr. 2004;79(5):755-64. PubMed PMID: 15113712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat consumption and primary open-angle glaucoma. AU - Kang,Jae H, AU - Pasquale,Louis R, AU - Willett,Walter C, AU - Rosner,Bernard A, AU - Egan,Kathleen M, AU - Faberowski,Nicholaus, AU - Hankinson,Susan E, PY - 2004/4/29/pubmed PY - 2004/5/27/medline PY - 2004/4/29/entrez SP - 755 EP - 64 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 79 IS - 5 N2 - BACKGROUND: Prostaglandin F(2alpha) analogues are effective intraocular-pressure-lowering drugs. Dietary fatty acids affect endogenous prostaglandin F(2alpha) concentrations and may thus influence intraocular pressure. OBJECTIVE: We prospectively examined dietary fat consumption in relation to primary open-angle glaucoma (POAG). DESIGN: Women (n = 76 199 in the Nurses' Health Study) and men (n = 40 306 in the Health Professionals Follow-Up Study) free of POAG in 1980 and 1986, respectively, were followed until 1996 if they were > or =40 y old and reported receiving eye exams during follow-up. Potential confounders were assessed on biennial questionnaires, and energy-adjusted cumulative averaged fat intakes were measured by using validated food-frequency questionnaires. We analyzed 474 self-reported POAG cases confirmed by medical chart review. Cohort-specific multivariate rate ratios (RRs) were obtained by using proportional hazards models and were then pooled. RESULTS: Major fats and fat subtypes were not independently associated with POAG risk. Pooled multivariate RRs (95% CI) for POAG comparing the highest with the lowest quintile of fat intake were as follows: 0.90 (0.67, 1.21) for total fat, 1.03 (0.77, 1.38) for saturated fat, 0.76 (0.56, 1.03) for monounsaturated fat, and 0.87 (0.66, 1.16) for polyunsaturated fat, none of which were statistically significant. We found a suggestive positive association between a higher ratio of n-3 to n-6 polyunsaturated fat and risk of POAG [RR = 1.49 (1.11, 2.01); P for trend = 0.10], which was stronger for high-tension POAG [RR = 1.68 (1.18, 2.39); P for trend = 0.009]. CONCLUSION: A high ratio of n-3 to n-6 polyunsaturated fat appears to increase the risk of POAG, particularly high-tension POAG. Further studies are needed. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15113712/Dietary_fat_consumption_and_primary_open_angle_glaucoma_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/79.5.755 DB - PRIME DP - Unbound Medicine ER -