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Successful treatment of Staphylococcus epidermidis hip prosthesis infection with oral linezolid.
Ann Pharmacother 2004; 38(6):986-8AP

Abstract

OBJECTIVE

To report a case of Staphylococcus epidermidis infection of a hip prosthesis successfully treated with oral linezolid.

CASE SUMMARY

A 46-year-old woman developed methicillin-resistant S. epidermidis (MRSE) infection of her prosthetic hip. She received oral linezolid 600 mg twice daily for one month; after that time, the biological inflammatory markers returned to normal.

DISCUSSION

One of the most serious complications of arthroplasty is joint prosthesis infection. It is mainly caused by gram-positive bacteria, in particular those of the genus staphylococcus. The increasing prevalence of gram-positive cocci that are resistant to antimicrobial agents has complicated the treatment of serious infections.

CONCLUSIONS

Oral linezolid appears to be an effective and well-tolerated treatment option for hip prosthesis infections due to MRSE.

Authors+Show Affiliations

Pharmacy Department, Rangueil University Hospital, Toulouse, France. imogenet@chu-clermontferrand@frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15113981

Citation

Mogenet, Ingrid, et al. "Successful Treatment of Staphylococcus Epidermidis Hip Prosthesis Infection With Oral Linezolid." The Annals of Pharmacotherapy, vol. 38, no. 6, 2004, pp. 986-8.
Mogenet I, Raetz-Dillon S, Canonge JM, et al. Successful treatment of Staphylococcus epidermidis hip prosthesis infection with oral linezolid. Ann Pharmacother. 2004;38(6):986-8.
Mogenet, I., Raetz-Dillon, S., Canonge, J. M., Archambaud, M., & Bonnet, E. (2004). Successful treatment of Staphylococcus epidermidis hip prosthesis infection with oral linezolid. The Annals of Pharmacotherapy, 38(6), pp. 986-8.
Mogenet I, et al. Successful Treatment of Staphylococcus Epidermidis Hip Prosthesis Infection With Oral Linezolid. Ann Pharmacother. 2004;38(6):986-8. PubMed PMID: 15113981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of Staphylococcus epidermidis hip prosthesis infection with oral linezolid. AU - Mogenet,Ingrid, AU - Raetz-Dillon,Sabine, AU - Canonge,Jean-Marie, AU - Archambaud,Maryse, AU - Bonnet,Eric, Y1 - 2004/04/27/ PY - 2004/4/29/pubmed PY - 2004/8/27/medline PY - 2004/4/29/entrez SP - 986 EP - 8 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 38 IS - 6 N2 - OBJECTIVE: To report a case of Staphylococcus epidermidis infection of a hip prosthesis successfully treated with oral linezolid. CASE SUMMARY: A 46-year-old woman developed methicillin-resistant S. epidermidis (MRSE) infection of her prosthetic hip. She received oral linezolid 600 mg twice daily for one month; after that time, the biological inflammatory markers returned to normal. DISCUSSION: One of the most serious complications of arthroplasty is joint prosthesis infection. It is mainly caused by gram-positive bacteria, in particular those of the genus staphylococcus. The increasing prevalence of gram-positive cocci that are resistant to antimicrobial agents has complicated the treatment of serious infections. CONCLUSIONS: Oral linezolid appears to be an effective and well-tolerated treatment option for hip prosthesis infections due to MRSE. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/15113981/Successful_treatment_of_Staphylococcus_epidermidis_hip_prosthesis_infection_with_oral_linezolid_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1D354?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -