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Relationship between adiponectin and metabolic variables in Caribbean offspring of patients with type 2 diabetes mellitus.
Horm Metab Res. 2004 Apr; 36(4):238-42.HM

Abstract

AIM

To examine the relationship between adiponectin and metabolic variables in the offspring of patients with type 2 diabetes mellitus.

METHODS

Fasting blood samples and anthropometric indices were taken from 34 subjects, offspring of patients with type 2 diabetes, and 24 healthy control subjects without any immediate family history of diabetes. Plasma glucose and serum adiponectin, insulin, triglycerides, total cholesterol, HDL and LDL cholesterol levels were measured, and insulin resistance (IR) was calculated based on the homeostasis model assessment (HOMA) method.

RESULTS

Offspring and control subjects were sex-matched, but the offspring were older and had higher body mass index and waist circumference than the control subjects (p < 0.05). The offspring had significantly higher mean fasting plasma glucose concentrations; however, their mean serum insulin, adiponectin, triglyceride, total cholesterol, HDL and LDL cholesterol and HOMA-derived IR levels did not significantly differ from those of the control subjects (p > 0.05). While the negative correlation between serum adiponectin and HDL cholesterol levels in the offspring remained statistically significant after adjusting for the effect of age, sex and BMI (r = -0.37, p < 0.05), the negative correlation between adiponectin and serum triglyceride, LDL cholesterol or IR levels became non-significant after controlling for the above variables (p > 0.05 in all cases).

CONCLUSION

The correlation between adiponectin and some known biochemical risk factors for developing diabetes and cardiovascular disease in the offspring of patients with diabetes warrants further study to evaluate its potential in assessing the risk of developing these disorders.

Authors+Show Affiliations

Unit of Pathology & Microbiology, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad. ezenwaka@tstt.net.ttNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15114523

Citation

Ezenwaka, C E., et al. "Relationship Between Adiponectin and Metabolic Variables in Caribbean Offspring of Patients With Type 2 Diabetes Mellitus." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 36, no. 4, 2004, pp. 238-42.
Ezenwaka CE, Kalloo R, Uhlig M, et al. Relationship between adiponectin and metabolic variables in Caribbean offspring of patients with type 2 diabetes mellitus. Horm Metab Res. 2004;36(4):238-42.
Ezenwaka, C. E., Kalloo, R., Uhlig, M., & Eckel, J. (2004). Relationship between adiponectin and metabolic variables in Caribbean offspring of patients with type 2 diabetes mellitus. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 36(4), 238-42.
Ezenwaka CE, et al. Relationship Between Adiponectin and Metabolic Variables in Caribbean Offspring of Patients With Type 2 Diabetes Mellitus. Horm Metab Res. 2004;36(4):238-42. PubMed PMID: 15114523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between adiponectin and metabolic variables in Caribbean offspring of patients with type 2 diabetes mellitus. AU - Ezenwaka,C E, AU - Kalloo,R, AU - Uhlig,M, AU - Eckel,J, PY - 2004/4/29/pubmed PY - 2004/12/16/medline PY - 2004/4/29/entrez SP - 238 EP - 42 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 36 IS - 4 N2 - AIM: To examine the relationship between adiponectin and metabolic variables in the offspring of patients with type 2 diabetes mellitus. METHODS: Fasting blood samples and anthropometric indices were taken from 34 subjects, offspring of patients with type 2 diabetes, and 24 healthy control subjects without any immediate family history of diabetes. Plasma glucose and serum adiponectin, insulin, triglycerides, total cholesterol, HDL and LDL cholesterol levels were measured, and insulin resistance (IR) was calculated based on the homeostasis model assessment (HOMA) method. RESULTS: Offspring and control subjects were sex-matched, but the offspring were older and had higher body mass index and waist circumference than the control subjects (p < 0.05). The offspring had significantly higher mean fasting plasma glucose concentrations; however, their mean serum insulin, adiponectin, triglyceride, total cholesterol, HDL and LDL cholesterol and HOMA-derived IR levels did not significantly differ from those of the control subjects (p > 0.05). While the negative correlation between serum adiponectin and HDL cholesterol levels in the offspring remained statistically significant after adjusting for the effect of age, sex and BMI (r = -0.37, p < 0.05), the negative correlation between adiponectin and serum triglyceride, LDL cholesterol or IR levels became non-significant after controlling for the above variables (p > 0.05 in all cases). CONCLUSION: The correlation between adiponectin and some known biochemical risk factors for developing diabetes and cardiovascular disease in the offspring of patients with diabetes warrants further study to evaluate its potential in assessing the risk of developing these disorders. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/15114523/Relationship_between_adiponectin_and_metabolic_variables_in_Caribbean_offspring_of_patients_with_type_2_diabetes_mellitus_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-814454 DB - PRIME DP - Unbound Medicine ER -