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Second malignant neoplasms in childhood acute lymphoblastic leukemia: primitive neuroectodermal tumor of the chest wall with germline p53 mutation as a second malignant neoplasm.
Am J Hematol. 2004 May; 76(1):52-6.AJ

Abstract

About 80% of children treated for acute lymphoblastic leukemia (ALL) will be long-term survivors. Second malignant neoplasm (SMNs) are a devastating sequelae observed on these children, with an estimated cumulative risk of 2-3.3% fifteen years after diagnosis. Primitive neuroectodermal tumor of bone (PNET) is rarely observed as a SMN following treatment of childhood ALL. The authors described the occurrence of a chest wall PNET of the bone at the site of a central line placement associated with both germ-line and tumor cell p53 mutation in a 8-year-old boy 1 year after completing therapy for standard risk ALL. A review of the literature of 25,051 children treated for ALL discovered 230 SMNs (0.99%), and only one case of PNET of the bone was noted among this group. The occurrence of a SMN in children treated for ALL is a rare event. Such an occurrence, in particular the development of an unusual SMN, should be evaluated for a germline p53 mutation.

Authors+Show Affiliations

Department of Pediatrics, Section of Hematology/Oncology, University of Louisville School of Medicine, Louisville, Kentucky, USA. csuarez@psm.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15114597

Citation

Suarez, Carlos R., et al. "Second Malignant Neoplasms in Childhood Acute Lymphoblastic Leukemia: Primitive Neuroectodermal Tumor of the Chest Wall With Germline P53 Mutation as a Second Malignant Neoplasm." American Journal of Hematology, vol. 76, no. 1, 2004, pp. 52-6.
Suarez CR, Bertolone SJ, Raj AB, et al. Second malignant neoplasms in childhood acute lymphoblastic leukemia: primitive neuroectodermal tumor of the chest wall with germline p53 mutation as a second malignant neoplasm. Am J Hematol. 2004;76(1):52-6.
Suarez, C. R., Bertolone, S. J., Raj, A. B., & Coventry, S. (2004). Second malignant neoplasms in childhood acute lymphoblastic leukemia: primitive neuroectodermal tumor of the chest wall with germline p53 mutation as a second malignant neoplasm. American Journal of Hematology, 76(1), 52-6.
Suarez CR, et al. Second Malignant Neoplasms in Childhood Acute Lymphoblastic Leukemia: Primitive Neuroectodermal Tumor of the Chest Wall With Germline P53 Mutation as a Second Malignant Neoplasm. Am J Hematol. 2004;76(1):52-6. PubMed PMID: 15114597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Second malignant neoplasms in childhood acute lymphoblastic leukemia: primitive neuroectodermal tumor of the chest wall with germline p53 mutation as a second malignant neoplasm. AU - Suarez,Carlos R, AU - Bertolone,Salvatore J, AU - Raj,Ashok B, AU - Coventry,Susan, PY - 2004/4/29/pubmed PY - 2004/6/4/medline PY - 2004/4/29/entrez SP - 52 EP - 6 JF - American journal of hematology JO - Am. J. Hematol. VL - 76 IS - 1 N2 - About 80% of children treated for acute lymphoblastic leukemia (ALL) will be long-term survivors. Second malignant neoplasm (SMNs) are a devastating sequelae observed on these children, with an estimated cumulative risk of 2-3.3% fifteen years after diagnosis. Primitive neuroectodermal tumor of bone (PNET) is rarely observed as a SMN following treatment of childhood ALL. The authors described the occurrence of a chest wall PNET of the bone at the site of a central line placement associated with both germ-line and tumor cell p53 mutation in a 8-year-old boy 1 year after completing therapy for standard risk ALL. A review of the literature of 25,051 children treated for ALL discovered 230 SMNs (0.99%), and only one case of PNET of the bone was noted among this group. The occurrence of a SMN in children treated for ALL is a rare event. Such an occurrence, in particular the development of an unusual SMN, should be evaluated for a germline p53 mutation. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/15114597/Second_malignant_neoplasms_in_childhood_acute_lymphoblastic_leukemia:_primitive_neuroectodermal_tumor_of_the_chest_wall_with_germline_p53_mutation_as_a_second_malignant_neoplasm_ L2 - https://doi.org/10.1002/ajh.20012 DB - PRIME DP - Unbound Medicine ER -