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Features of isolated post-challenge hyperglycaemia in Jamaican adults.
West Indian Med J. 2004 Jan; 53(1):7-11.WI

Abstract

Isolated post-challenge hyperglycaemia (IPH) can be defined as a two-hour plasma glucose concentration > or = 11.1 mmol/L with a fasting plasma glucose concentration < 7.0 mmol/L. The aim of this prospective study was to determine the prevalence of IPH in a cohort of Jamaican individuals, and to determine if simple clinical features may predict the presence and subsequent diagnosis of IPH. A cohort of 1694 adults aged 25-74 years without physician-diagnosed diabetes mellitus was randomly selected. An oral glucose tolerance test (OGTT) was performed. Anthropometry, blood pressure and lipid profiles were measured. The prevalence of undiagnosed diabetes mellitus by the 1999 World Health Organization criteria was 6.4%. IPH accounted for 24% of these cases and 1.4% of the entire population. Individuals with IPH were significantly older, with greater body mass index, waist-hip ratio, systolic blood pressure, fasting blood glucose, total cholesterol and LDL-cholesterol than individuals with normal glucose tolerance. Individuals with IPH were not significantly different from individuals with fasting plasma glucose levels > or = 7 mmol/L (i.e. fasting hyperglycaemia) in anthropometry or blood pressure. However, total cholesterol and LDL-C were significantly elevated in the IPH group. OGTT screening of individuals with impaired fasting glucose (i.e. 6.1-6.9 mmol/l) could reduce the IPH group by 50%. Reducing the threshold for fasting glucose to 5.6 mmol/L would correctly classify 87% of the population. We concluded that individuals with IPH have features of the metabolic syndrome, which can aid in selection for screening. OGTT screening of individuals with fasting glucose values of 5.6-6.9 mmol/l is needed to identify IPH.

Authors+Show Affiliations

Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Kingston 7, Jamaica, West Indies. michael.boyne@uwimona.edu.jmNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15114886

Citation

Boyne, M S., et al. "Features of Isolated Post-challenge Hyperglycaemia in Jamaican Adults." The West Indian Medical Journal, vol. 53, no. 1, 2004, pp. 7-11.
Boyne MS, Sargeant LA, Bennett FI, et al. Features of isolated post-challenge hyperglycaemia in Jamaican adults. West Indian Med J. 2004;53(1):7-11.
Boyne, M. S., Sargeant, L. A., Bennett, F. I., Cooper, R. S., Wilks, R. J., & Forrester, T. E. (2004). Features of isolated post-challenge hyperglycaemia in Jamaican adults. The West Indian Medical Journal, 53(1), 7-11.
Boyne MS, et al. Features of Isolated Post-challenge Hyperglycaemia in Jamaican Adults. West Indian Med J. 2004;53(1):7-11. PubMed PMID: 15114886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Features of isolated post-challenge hyperglycaemia in Jamaican adults. AU - Boyne,M S, AU - Sargeant,L A, AU - Bennett,F I, AU - Cooper,R S, AU - Wilks,R J, AU - Forrester,T E, PY - 2004/4/30/pubmed PY - 2004/7/21/medline PY - 2004/4/30/entrez SP - 7 EP - 11 JF - The West Indian medical journal JO - West Indian Med J VL - 53 IS - 1 N2 - Isolated post-challenge hyperglycaemia (IPH) can be defined as a two-hour plasma glucose concentration > or = 11.1 mmol/L with a fasting plasma glucose concentration < 7.0 mmol/L. The aim of this prospective study was to determine the prevalence of IPH in a cohort of Jamaican individuals, and to determine if simple clinical features may predict the presence and subsequent diagnosis of IPH. A cohort of 1694 adults aged 25-74 years without physician-diagnosed diabetes mellitus was randomly selected. An oral glucose tolerance test (OGTT) was performed. Anthropometry, blood pressure and lipid profiles were measured. The prevalence of undiagnosed diabetes mellitus by the 1999 World Health Organization criteria was 6.4%. IPH accounted for 24% of these cases and 1.4% of the entire population. Individuals with IPH were significantly older, with greater body mass index, waist-hip ratio, systolic blood pressure, fasting blood glucose, total cholesterol and LDL-cholesterol than individuals with normal glucose tolerance. Individuals with IPH were not significantly different from individuals with fasting plasma glucose levels > or = 7 mmol/L (i.e. fasting hyperglycaemia) in anthropometry or blood pressure. However, total cholesterol and LDL-C were significantly elevated in the IPH group. OGTT screening of individuals with impaired fasting glucose (i.e. 6.1-6.9 mmol/l) could reduce the IPH group by 50%. Reducing the threshold for fasting glucose to 5.6 mmol/L would correctly classify 87% of the population. We concluded that individuals with IPH have features of the metabolic syndrome, which can aid in selection for screening. OGTT screening of individuals with fasting glucose values of 5.6-6.9 mmol/l is needed to identify IPH. SN - 0043-3144 UR - https://www.unboundmedicine.com/medline/citation/15114886/Features_of_isolated_post_challenge_hyperglycaemia_in_Jamaican_adults_ L2 - https://ClinicalTrials.gov/search/term=15114886 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -