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Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients.
Isr Med Assoc J 2004; 6(4):213-7IM

Abstract

BACKGROUND

Hyperhomocysteinemia is a well-recognized risk factor for accelerated atherosclerosis in hemodialysis patients.

OBJECTIVES

To examine the effects of two doses of vitamins B6 and B12 and folic acid on homocysteine levels in hemodialysis patients and assess the functional impact of the methylenetetrahydrofolate reductase genotype on the response to treatment.

METHODS

In a randomized prospective study, we assessed the effects of folic acid and two doses of B-vitamins in 50 hemodialysis patients with hyperhomocysteinemia. Patients were divided into two groups: 26 patients (group A) who received 25 mg of vitamin B6 daily and one monthly injection of 200 microg vitamin B12, and 24 patients (group B) who received 100 mg of vitamin B6 daily and one monthly injection of 1,000 microg vitamin B12. In addition, both groups received 15 mg folic acid daily. Patients were evaluated for homocysteine levels as well as for coagulation and a thorough lipid profile. Baseline Hcy levels were determined after at least 4 weeks washout from all folic acid and B-vitamins that were given. MFTHR alleles were analyzed, as were activated protein C resistance, von Willebrand factor and lupus anticoagulant.

RESULTS

Basal plasma Hcy levels were significantly elevated in hemodialysis patients compared with normal subjects (33.8 +/- 4.3 vs. 4.5 to 14.0 micromol/L). Following treatment, Hcy levels were significantly reduced to 21.2 +/- 1.6 in group A and 18.6 +/- 1.4 micromol/L in group B (P < 0.01). There was no difference in Hcy reduction following the administration of either high or low dosage of vitamins B6 and B12 utilized in the present study. There was no correlation between Hcy levels or thrombophilia and high incidence of thrombotic episodes in hemodialysis patients. Genotypic evaluation of MTHFR revealed that the presence of homozygous thermolabile MTHFR (n = 5) was associated with higher Hcy levels and better response to treatment (Hcy levels decreased by 58%, from 46.2 +/- 14.6 to 19.48 + 4.1 micromol/ L following treatment). In patients with heterozygous thermolabile MTHFR (n = 25), Hcy levels decreased by 34%, from 31.2 +/- 3.7 to 18.1 +/- 1.1 micromol/L following treatment. The efficacy of high and low doses of B-vitamins on the reduction of homocysteine levels was comparable.

CONCLUSIONS

Treatment with B-vitamins in combination with folic acid significantly decreased homocysteine levels in hemodialysis patients, independently of the tested doses. In addition, mutations in MTHFR were associated with elevated plasma levels of Hcy. Neither vascular access nor the presence of diabetes was associated with higher pre- or post-treatment homocysteine level.

Authors+Show Affiliations

Department of Nephrology, Rambam Medical Center, Haifa, Israel. f_nakhoul@rambam.health.gov.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15115259

Citation

Nakhoul, Farid, et al. "Comparative Study of Response to Treatment With Supraphysiologic Doses of B-vitamins in Hyperhomocysteinemic Hemodialysis Patients." The Israel Medical Association Journal : IMAJ, vol. 6, no. 4, 2004, pp. 213-7.
Nakhoul F, Abassi Z, Plawner M, et al. Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients. Isr Med Assoc J. 2004;6(4):213-7.
Nakhoul, F., Abassi, Z., Plawner, M., Khankin, E., Ramadan, R., Lanir, N., ... Green, J. (2004). Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients. The Israel Medical Association Journal : IMAJ, 6(4), pp. 213-7.
Nakhoul F, et al. Comparative Study of Response to Treatment With Supraphysiologic Doses of B-vitamins in Hyperhomocysteinemic Hemodialysis Patients. Isr Med Assoc J. 2004;6(4):213-7. PubMed PMID: 15115259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients. AU - Nakhoul,Farid, AU - Abassi,Zaid, AU - Plawner,Michal, AU - Khankin,Eli, AU - Ramadan,Rawi, AU - Lanir,Noami, AU - Brenner,Benjamine, AU - Green,Jacob, PY - 2004/4/30/pubmed PY - 2004/5/21/medline PY - 2004/4/30/entrez SP - 213 EP - 7 JF - The Israel Medical Association journal : IMAJ JO - Isr. Med. Assoc. J. VL - 6 IS - 4 N2 - BACKGROUND: Hyperhomocysteinemia is a well-recognized risk factor for accelerated atherosclerosis in hemodialysis patients. OBJECTIVES: To examine the effects of two doses of vitamins B6 and B12 and folic acid on homocysteine levels in hemodialysis patients and assess the functional impact of the methylenetetrahydrofolate reductase genotype on the response to treatment. METHODS: In a randomized prospective study, we assessed the effects of folic acid and two doses of B-vitamins in 50 hemodialysis patients with hyperhomocysteinemia. Patients were divided into two groups: 26 patients (group A) who received 25 mg of vitamin B6 daily and one monthly injection of 200 microg vitamin B12, and 24 patients (group B) who received 100 mg of vitamin B6 daily and one monthly injection of 1,000 microg vitamin B12. In addition, both groups received 15 mg folic acid daily. Patients were evaluated for homocysteine levels as well as for coagulation and a thorough lipid profile. Baseline Hcy levels were determined after at least 4 weeks washout from all folic acid and B-vitamins that were given. MFTHR alleles were analyzed, as were activated protein C resistance, von Willebrand factor and lupus anticoagulant. RESULTS: Basal plasma Hcy levels were significantly elevated in hemodialysis patients compared with normal subjects (33.8 +/- 4.3 vs. 4.5 to 14.0 micromol/L). Following treatment, Hcy levels were significantly reduced to 21.2 +/- 1.6 in group A and 18.6 +/- 1.4 micromol/L in group B (P < 0.01). There was no difference in Hcy reduction following the administration of either high or low dosage of vitamins B6 and B12 utilized in the present study. There was no correlation between Hcy levels or thrombophilia and high incidence of thrombotic episodes in hemodialysis patients. Genotypic evaluation of MTHFR revealed that the presence of homozygous thermolabile MTHFR (n = 5) was associated with higher Hcy levels and better response to treatment (Hcy levels decreased by 58%, from 46.2 +/- 14.6 to 19.48 + 4.1 micromol/ L following treatment). In patients with heterozygous thermolabile MTHFR (n = 25), Hcy levels decreased by 34%, from 31.2 +/- 3.7 to 18.1 +/- 1.1 micromol/L following treatment. The efficacy of high and low doses of B-vitamins on the reduction of homocysteine levels was comparable. CONCLUSIONS: Treatment with B-vitamins in combination with folic acid significantly decreased homocysteine levels in hemodialysis patients, independently of the tested doses. In addition, mutations in MTHFR were associated with elevated plasma levels of Hcy. Neither vascular access nor the presence of diabetes was associated with higher pre- or post-treatment homocysteine level. SN - 1565-1088 UR - https://www.unboundmedicine.com/medline/citation/15115259/Comparative_study_of_response_to_treatment_with_supraphysiologic_doses_of_B_vitamins_in_hyperhomocysteinemic_hemodialysis_patients_ L2 - http://www.ima.org.il/IMAJ/ViewArticle.aspx?year=2004&amp;month=04&amp;page=213 DB - PRIME DP - Unbound Medicine ER -