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Treatment of Microsporum spp. tinea capitis with pulsed oral terbinafine.
Clin Exp Dermatol. 2004 May; 29(3):300-3.CE

Abstract

Oral terbinafine is widely used in the treatment of superficial dermatomycoses as well as subcutaneous and systemic mycoses. It is also useful in treating tinea capitis, although for Microsporum canis and some ectothrix organisms, the effectiveness of the drug may be less than for some endothrix infections. In this study, we undertook a double-blind randomized trial comparing standard and double doses of terbinafine given in a pulsed protocol (1 week on, 3 weeks off) in treating Microsporum spp. tinea capitis in 42 individuals. We found that pulsed terbinafine at a higher dose did not improve treatment efficacy. However, our data clearly demonstrated that the duration of treatment is an important factor in determining clinical outcome and cure. Two pulses of standard dose terbinafine were found to be sufficient for treating most cases of Microsporum spp. tinea capitis, although additional treatment (a third pulse) may be needed if clinical improvement is not evident at 8 weeks after initiating therapy.

Authors+Show Affiliations

Institute of Dermatology, Bangkok, Thailand. rataporn@health.moph.go.thNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15115516

Citation

Ungpakorn, R, et al. "Treatment of Microsporum Spp. Tinea Capitis With Pulsed Oral Terbinafine." Clinical and Experimental Dermatology, vol. 29, no. 3, 2004, pp. 300-3.
Ungpakorn R, Ayutyanont T, Reangchainam S, et al. Treatment of Microsporum spp. tinea capitis with pulsed oral terbinafine. Clin Exp Dermatol. 2004;29(3):300-3.
Ungpakorn, R., Ayutyanont, T., Reangchainam, S., & Supanya, S. (2004). Treatment of Microsporum spp. tinea capitis with pulsed oral terbinafine. Clinical and Experimental Dermatology, 29(3), 300-3.
Ungpakorn R, et al. Treatment of Microsporum Spp. Tinea Capitis With Pulsed Oral Terbinafine. Clin Exp Dermatol. 2004;29(3):300-3. PubMed PMID: 15115516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of Microsporum spp. tinea capitis with pulsed oral terbinafine. AU - Ungpakorn,R, AU - Ayutyanont,T, AU - Reangchainam,S, AU - Supanya,S, PY - 2004/4/30/pubmed PY - 2004/7/9/medline PY - 2004/4/30/entrez SP - 300 EP - 3 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 29 IS - 3 N2 - Oral terbinafine is widely used in the treatment of superficial dermatomycoses as well as subcutaneous and systemic mycoses. It is also useful in treating tinea capitis, although for Microsporum canis and some ectothrix organisms, the effectiveness of the drug may be less than for some endothrix infections. In this study, we undertook a double-blind randomized trial comparing standard and double doses of terbinafine given in a pulsed protocol (1 week on, 3 weeks off) in treating Microsporum spp. tinea capitis in 42 individuals. We found that pulsed terbinafine at a higher dose did not improve treatment efficacy. However, our data clearly demonstrated that the duration of treatment is an important factor in determining clinical outcome and cure. Two pulses of standard dose terbinafine were found to be sufficient for treating most cases of Microsporum spp. tinea capitis, although additional treatment (a third pulse) may be needed if clinical improvement is not evident at 8 weeks after initiating therapy. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/15115516/Treatment_of_Microsporum_spp__tinea_capitis_with_pulsed_oral_terbinafine_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0307-6938&date=2004&volume=29&issue=3&spage=300 DB - PRIME DP - Unbound Medicine ER -