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Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men.
Eur J Clin Nutr 2004; 58(5):819-27EJ

Abstract

OBJECTIVE

To investigate the effect of moderate changes in dietary fatty acid profile on postprandial risk factors for cardiovascular disease (CVD).

DESIGN

Double-blind, randomised, crossover, intervention trial.

SETTING

: University of Auckland Human Nutrition Unit, New Zealand.

SUBJECTS

A total of 18 lean healthy men.

INTERVENTION

A dairy butter fat modified to reduce the saturated:unsaturated fatty acid ratio and a conventional high saturated butter fat were given on two separate occasions as a high-fat test meal (59+/-4 g fat; 71 en% fat) at breakfast. A fat exclusion lunch, dinner and snacks were also given. Blood samples were collected at 0 (baseline), 1, 3, 6, 10 and 24 h.

RESULTS

Maximum peak in total triacylglycerol (TAG) occurred 3 h postprandially and was highest on modified treatment (diet, P<0.05) due predominantly to increased TAG within the chylomicron-rich fraction. Transient peaks in total-, LDL- and HDL-cholesterol occurred postprandially, but did not differ between dietary treatments (P>0.05). There were no differential effects of diet on postprandial free fatty acids, apo A, apo B, glucose, insulin, amylin or haemostatic clotting factors (P>0.05).

CONCLUSIONS

In a group of healthy young men, replacement of 16% of total saturated fatty acids by mono- and polyunsaturated fats within a dairy lipid did not induce postprandial changes in CVD risk that may be considered beneficial for health.

SPONSORSHIP

Fonterra, Wellington; New Zealand.

Authors+Show Affiliations

Department of Medicine, University of Auckland, New Zealand. s.poppitt@auckland.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15116086

Citation

Poppitt, S D., et al. "Effect of Moderate Changes in Dietary Fatty Acid Profile On Postprandial Lipaemia, Haemostatic and Related CVD Risk Factors in Healthy Men." European Journal of Clinical Nutrition, vol. 58, no. 5, 2004, pp. 819-27.
Poppitt SD, Keogh GF, Mulvey TB, et al. Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men. Eur J Clin Nutr. 2004;58(5):819-27.
Poppitt, S. D., Keogh, G. F., Mulvey, T. B., Phillips, A., McArdle, B. H., MacGibbon, A. K., & Cooper, G. J. (2004). Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men. European Journal of Clinical Nutrition, 58(5), pp. 819-27.
Poppitt SD, et al. Effect of Moderate Changes in Dietary Fatty Acid Profile On Postprandial Lipaemia, Haemostatic and Related CVD Risk Factors in Healthy Men. Eur J Clin Nutr. 2004;58(5):819-27. PubMed PMID: 15116086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men. AU - Poppitt,S D, AU - Keogh,G F, AU - Mulvey,T B, AU - Phillips,A, AU - McArdle,B H, AU - MacGibbon,A K H, AU - Cooper,G J S, PY - 2004/4/30/pubmed PY - 2005/3/4/medline PY - 2004/4/30/entrez SP - 819 EP - 27 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 5 N2 - OBJECTIVE: To investigate the effect of moderate changes in dietary fatty acid profile on postprandial risk factors for cardiovascular disease (CVD). DESIGN: Double-blind, randomised, crossover, intervention trial. SETTING: : University of Auckland Human Nutrition Unit, New Zealand. SUBJECTS: A total of 18 lean healthy men. INTERVENTION: A dairy butter fat modified to reduce the saturated:unsaturated fatty acid ratio and a conventional high saturated butter fat were given on two separate occasions as a high-fat test meal (59+/-4 g fat; 71 en% fat) at breakfast. A fat exclusion lunch, dinner and snacks were also given. Blood samples were collected at 0 (baseline), 1, 3, 6, 10 and 24 h. RESULTS: Maximum peak in total triacylglycerol (TAG) occurred 3 h postprandially and was highest on modified treatment (diet, P<0.05) due predominantly to increased TAG within the chylomicron-rich fraction. Transient peaks in total-, LDL- and HDL-cholesterol occurred postprandially, but did not differ between dietary treatments (P>0.05). There were no differential effects of diet on postprandial free fatty acids, apo A, apo B, glucose, insulin, amylin or haemostatic clotting factors (P>0.05). CONCLUSIONS: In a group of healthy young men, replacement of 16% of total saturated fatty acids by mono- and polyunsaturated fats within a dairy lipid did not induce postprandial changes in CVD risk that may be considered beneficial for health. SPONSORSHIP: Fonterra, Wellington; New Zealand. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15116086/Effect_of_moderate_changes_in_dietary_fatty_acid_profile_on_postprandial_lipaemia_haemostatic_and_related_CVD_risk_factors_in_healthy_men_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601882 DB - PRIME DP - Unbound Medicine ER -