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Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults.
J Clin Psychopharmacol 2004; 24(3):305-13JC

Abstract

The effects of cannabis extracts on nocturnal sleep, early-morning performance, memory, and sleepiness were studied in 8 healthy volunteers (4 males, 4 females; 21 to 34 years). The study was double-blind and placebo-controlled with a 4-way crossover design. The 4 treatments were placebo, 15 mg Delta-9-tetrahydrocannabinol (THC), 5 mg THC combined with 5 mg cannabidiol (CBD), and 15 mg THC combined with 15 mg CBD. These were formulated in 50:50 ethanol to propylene glycol and administered using an oromucosal spray during a 30-minute period from 10 pm. The electroencephalogram was recorded during the sleep period (11 pm to 7 am). Performance, sleep latency, and subjective assessments of sleepiness and mood were measured from 8:30 am (10 hours after drug administration). There were no effects of 15 mg THC on nocturnal sleep. With the concomitant administration of the drugs (5 mg THC and 5 mg CBD to 15 mg THC and 15 mg CBD), there was a decrease in stage 3 sleep, and with the higher dose combination, wakefulness was increased. The next day, with 15 mg THC, memory was impaired, sleep latency was reduced, and the subjects reported increased sleepiness and changes in mood. With the lower dose combination, reaction time was faster on the digit recall task, and with the higher dose combination, subjects reported increased sleepiness and changes in mood. Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC.

Authors+Show Affiliations

QinetiQ Ltd, Centre for Human Sciences, Cody Technology Park, Ively Road, Farnborough, Hampshire GU14 0LX, UK. annicholson@QinetiQ.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15118485

Citation

Nicholson, Anthony N., et al. "Effect of Delta-9-tetrahydrocannabinol and Cannabidiol On Nocturnal Sleep and Early-morning Behavior in Young Adults." Journal of Clinical Psychopharmacology, vol. 24, no. 3, 2004, pp. 305-13.
Nicholson AN, Turner C, Stone BM, et al. Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004;24(3):305-13.
Nicholson, A. N., Turner, C., Stone, B. M., & Robson, P. J. (2004). Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. Journal of Clinical Psychopharmacology, 24(3), pp. 305-13.
Nicholson AN, et al. Effect of Delta-9-tetrahydrocannabinol and Cannabidiol On Nocturnal Sleep and Early-morning Behavior in Young Adults. J Clin Psychopharmacol. 2004;24(3):305-13. PubMed PMID: 15118485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. AU - Nicholson,Anthony N, AU - Turner,Claire, AU - Stone,Barbara M, AU - Robson,Philip J, PY - 2004/5/1/pubmed PY - 2004/9/8/medline PY - 2004/5/1/entrez SP - 305 EP - 13 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 24 IS - 3 N2 - The effects of cannabis extracts on nocturnal sleep, early-morning performance, memory, and sleepiness were studied in 8 healthy volunteers (4 males, 4 females; 21 to 34 years). The study was double-blind and placebo-controlled with a 4-way crossover design. The 4 treatments were placebo, 15 mg Delta-9-tetrahydrocannabinol (THC), 5 mg THC combined with 5 mg cannabidiol (CBD), and 15 mg THC combined with 15 mg CBD. These were formulated in 50:50 ethanol to propylene glycol and administered using an oromucosal spray during a 30-minute period from 10 pm. The electroencephalogram was recorded during the sleep period (11 pm to 7 am). Performance, sleep latency, and subjective assessments of sleepiness and mood were measured from 8:30 am (10 hours after drug administration). There were no effects of 15 mg THC on nocturnal sleep. With the concomitant administration of the drugs (5 mg THC and 5 mg CBD to 15 mg THC and 15 mg CBD), there was a decrease in stage 3 sleep, and with the higher dose combination, wakefulness was increased. The next day, with 15 mg THC, memory was impaired, sleep latency was reduced, and the subjects reported increased sleepiness and changes in mood. With the lower dose combination, reaction time was faster on the digit recall task, and with the higher dose combination, subjects reported increased sleepiness and changes in mood. Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC. SN - 0271-0749 UR - https://www.unboundmedicine.com/medline/citation/15118485/Effect_of_Delta_9_tetrahydrocannabinol_and_cannabidiol_on_nocturnal_sleep_and_early_morning_behavior_in_young_adults_ L2 - http://Insights.ovid.com/pubmed?pmid=15118485 DB - PRIME DP - Unbound Medicine ER -