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Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae).
J Ethnopharmacol. 2004 Apr; 91(2-3):215-8.JE

Abstract

An aqueous extract of the aerial part of Peperomia pellucida (L.) HBK (Piperaceae) was tested for anti-inflammatory (paw edema induced by carrageenin and arachidonic acid) and analgesic activity (abdominal writhes and hot plate) in rats and mice, respectively. Oral administration of 200 and 400 mg/kg of the aqueous extract exhibited an anti-inflammatory activity in the carrageenin test, which was based on interference with prostaglandin synthesis, as confirmed by the arachidonic acid test. In the abdominal writhing test induced by acetic acid, 400 mg/kg of the plant extract had the highest analgesic activity, whereas in the hot-plate test the best dose was 100 mg/kg. The LD(50) showed that Peperomia pellucida (5000 mg/kg) presented low toxicity.

Authors+Show Affiliations

Laboratório de Farmacologia, Departamento de Fisiologia/CCBS, Universidade Federal de Sergipe, Campus Universitário, São Cristóvão, SE CEP 49100-000, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15120441

Citation

de Fátima Arrigoni-Blank, Maria, et al. "Anti-inflammatory and Analgesic Activity of Peperomia Pellucida (L.) HBK (Piperaceae)." Journal of Ethnopharmacology, vol. 91, no. 2-3, 2004, pp. 215-8.
de Fátima Arrigoni-Blank M, Dmitrieva EG, Franzotti EM, et al. Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae). J Ethnopharmacol. 2004;91(2-3):215-8.
de Fátima Arrigoni-Blank, M., Dmitrieva, E. G., Franzotti, E. M., Antoniolli, A. R., Andrade, M. R., & Marchioro, M. (2004). Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae). Journal of Ethnopharmacology, 91(2-3), 215-8.
de Fátima Arrigoni-Blank M, et al. Anti-inflammatory and Analgesic Activity of Peperomia Pellucida (L.) HBK (Piperaceae). J Ethnopharmacol. 2004;91(2-3):215-8. PubMed PMID: 15120441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae). AU - de Fátima Arrigoni-Blank,Maria, AU - Dmitrieva,Elena G, AU - Franzotti,Elaine Maria, AU - Antoniolli,Angelo Roberto, AU - Andrade,Márcio Roberto, AU - Marchioro,Murilo, PY - 2001/01/16/received PY - 2003/10/31/revised PY - 2003/12/18/accepted PY - 2004/5/4/pubmed PY - 2004/8/7/medline PY - 2004/5/4/entrez SP - 215 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 91 IS - 2-3 N2 - An aqueous extract of the aerial part of Peperomia pellucida (L.) HBK (Piperaceae) was tested for anti-inflammatory (paw edema induced by carrageenin and arachidonic acid) and analgesic activity (abdominal writhes and hot plate) in rats and mice, respectively. Oral administration of 200 and 400 mg/kg of the aqueous extract exhibited an anti-inflammatory activity in the carrageenin test, which was based on interference with prostaglandin synthesis, as confirmed by the arachidonic acid test. In the abdominal writhing test induced by acetic acid, 400 mg/kg of the plant extract had the highest analgesic activity, whereas in the hot-plate test the best dose was 100 mg/kg. The LD(50) showed that Peperomia pellucida (5000 mg/kg) presented low toxicity. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15120441/Anti_inflammatory_and_analgesic_activity_of_Peperomia_pellucida__L___HBK__Piperaceae__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378874104000297 DB - PRIME DP - Unbound Medicine ER -